PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26471090-0	2015	Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5.	saponarin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24	
26471090-2	2015	Saponarin suppressed the rate of gluconeogenesis and increased cellular glucose uptake in HepG2 and TE671 cells by regulating AMPK.	saponarin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	126-130	
26471090-4	2015	Instead, saponarin increased intracellular calcium levels and induced AMPK phosphorylation, which was diminished by co-stimulation with STO-609, an inhibitor of CAMKKbeta.	saponarin	9-18	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	70-74	
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
26471090-9	2015	Collectively, these results suggest that saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.	saponarin	41-50	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65