PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19828235-4	2010	Induction of G1 arrest by widdrol was correlated with induction of Chk2, p53 phosphorylation and CDK inhibitor p21 expression as well as inhibition of cyclin E, cyclin-dependent kinase (CDK2) and retinoblastoma protein (pRB).	widdrol	26-33	cyclin dependent kinase inhibitor 1A	Homo sapiens	111-114	
22573158-7	2012	Therefore, these findings clearly suggest that widdrol blocks preadipocyte growth and differentiation through the inhibition of mitotic clonal expansion by p21- and Rb-dependent G1 arrest and can be developed as a potent anti-adipogenic agent for reducing obesity.	widdrol	47-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	156-159	
22160829-0	2012	Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.	widdrol	0-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-81	
22160829-7	2012	Based on this result, the change of proteins related in checkpoint pathway was examined over a time course of 0.5-24 h. Treatment of HT29 cells with widdrol elicits the following: (1) phosphorylation of Chk2 and p53, (2) reduction of cell division cycle 25A (Cdc25A) expression, (3) increase of Cdk inhibitor p21 expression, and (4) decrease of the levels of Cdk2 and cyclin E expression in a time-dependent manner.	widdrol	149-156	cyclin dependent kinase inhibitor 1A	Homo sapiens	309-312