PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16537514-5	2006	Kinetic analyses showed time-dependent inhibition, a hallmark of covalent inactivation, and biochemical studies of the interaction of extracellular signal-regulated kinase (ERK)2 with hypothemycin confirmed covalent adduct formation.	hypothemycin	184-196	mitogen-activated protein kinase 1	Homo sapiens	134-178	
26371861-6	2015	In addition, hypothemycin suppressed LPS-induced phosphorylation of p38 MAPK and ERK.	hypothemycin	13-25	mitogen-activated protein kinase 1	Homo sapiens	72-76	
26371861-6	2015	In addition, hypothemycin suppressed LPS-induced phosphorylation of p38 MAPK and ERK.	hypothemycin	13-25	mitogen-activated protein kinase 1	Homo sapiens	81-84	
26371861-7	2015	Moreover, knockdown of tristetraprolin (TTP), which is an important trans-acting regulator of TNF-alpha mRNA stability and downstream target of p38 MAPK and ERK, reversed hypothemycin-mediated inhibition of TNF-alpha mRNA expression.	hypothemycin	171-183	mitogen-activated protein kinase 1	Homo sapiens	148-152	
26371861-7	2015	Moreover, knockdown of tristetraprolin (TTP), which is an important trans-acting regulator of TNF-alpha mRNA stability and downstream target of p38 MAPK and ERK, reversed hypothemycin-mediated inhibition of TNF-alpha mRNA expression.	hypothemycin	171-183	mitogen-activated protein kinase 1	Homo sapiens	157-160	
26371861-8	2015	Collectively, our results suggest that hypothemycin suppresses TNF-alpha production by TTP-dependent destabilization of TNF-alpha mRNA and this is mediated, at least in part, by blocking the activation of p38 MAPK and ERK.	hypothemycin	39-51	mitogen-activated protein kinase 1	Homo sapiens	209-213	
26371861-8	2015	Collectively, our results suggest that hypothemycin suppresses TNF-alpha production by TTP-dependent destabilization of TNF-alpha mRNA and this is mediated, at least in part, by blocking the activation of p38 MAPK and ERK.	hypothemycin	39-51	mitogen-activated protein kinase 1	Homo sapiens	218-221	
18571434-0	2008	Molecular modeling and crystal structure of ERK2-hypothemycin complexes.	hypothemycin	49-61	mitogen-activated protein kinase 1	Homo sapiens	44-48	
18571434-3	2008	As a paradigm for the structures of the cis-enone resorcylic acid lactone complexes with this subset of kinases, we have modeled the structure of ERK2-hypothemycin reversible and covalent complexes using docking and extended molecular dynamics simulations.	hypothemycin	151-163	mitogen-activated protein kinase 1	Homo sapiens	146-150	
16537514-8	2006	Among cells without mitogen receptor targets, those harboring an ERK pathway-activating B-RAF V600E mutation were selectively and potently inhibited by hypothemycin.	hypothemycin	152-164	mitogen-activated protein kinase 1	Homo sapiens	65-68	
16537514-9	2006	Hypothemycin also prevented stimulated activation of the p38 cascade through inhibition of the Cys-containing targets MEK3/6 and TGF-beta-activated kinase 1 and of the JNK/SAPK (c-Jun N-terminal kinase/stress-activated protein kinase) cascade through inhibition of MEK4/7.	hypothemycin	0-12	mitogen-activated protein kinase 1	Homo sapiens	57-60