PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10947158-9 2000 In spleen cell suspensions, spermine suppressed the release of IFN-gamma induced either by LPS or anti-CD3 antibody. Spermine 28-36 interferon gamma Mus musculus 63-72 15638127-16 2004 IL-12/IL-18 or IFNgamma activation, mainly in MHV3 infected cells, led to a decreased synthesis of polyamines, notably spermine, only in A/J BMMphi. Spermine 119-127 interferon gamma Mus musculus 15-23 10947158-10 2000 In summary, spermine exerts anti-inflammatory effects by suppressing IL-12 and IFN-gamma and by augmenting the production of IL-10. Spermine 12-20 interferon gamma Mus musculus 79-88 7532082-2 1994 We have recently found that in the presence, but not in the absence, of foetal calf serum, spermine inhibits the production of nitric oxide (NO) in cultured J774.2 macrophages stimulated with bacterial endotoxin (lipopolysaccharide; LPS) or with gamma-interferon (IFN), showing that polyamines may act as suppressants of NO-mediated immune functions. Spermine 91-99 interferon gamma Mus musculus 246-268