PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15982768-1 2005 Endogenous polyamines like spermine are known to have four distinct effects on recombinant N-methyl-d-aspartate (NMDA) receptor channels: voltage-dependent inhibition, glycine-dependent stimulation, glycine-independent stimulation and decreased affinity to the agonist (l-glutamate). Spermine 27-35 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 91-127 10347236-0 1999 A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein. Spermine 99-107 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 57-86 7534390-4 1994 Arcaine, a putative competitive antagonist at the polyamine-binding site on the N-methyl-D-aspartate (NMDA) receptor-channel complex, reduced the spermine enhancement of ACh-induced whole-cell currents. Spermine 146-154 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 80-116 8649353-0 1996 An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons. Spermine 108-116 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 54-83 8161453-2 1994 NR1 subunits with an N-terminal insert (termed N1) form receptors in Xenopus oocytes with greatly reduced potentiation by spermine and Zn2+. Spermine 122-130 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 0-3 8161453-8 1994 The positively charged N1 may increase NMDA currents by causing a conformational change similar to that produced by spermine and Zn2+ in NR1 receptors lacking N1. Spermine 116-124 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 137-140 8341692-5 1993 NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine. Spermine 185-193 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 0-3 8341692-5 1993 NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine. Spermine 185-193 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 47-50 8341692-5 1993 NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine. Spermine 185-193 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 47-50 8341692-5 1993 NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine. Spermine 185-193 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 47-50 8341692-6 1993 In contrast, those receptor variants with the N-terminal insert (NR1(100), NR1(101), and NR1(111)) showed a lower agonist affinity and little or no spermine potentiation at saturating glycine. Spermine 148-156 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 65-68 1838407-4 1991 These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex. Spermine 163-171 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 102-115 1838407-4 1991 These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex. Spermine 163-171 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 213-226 1702227-5 1990 Our results demonstrate that spermine potentiates the response of the NMDA receptor but has no effect on responses to kainate and quisqualate. Spermine 29-37 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 70-83 1702227-6 1990 Furthermore, spermine increases the maximum response to NMDA and glycine and acts, at least in part, by increasing the apparent affinity of the NMDA receptor/channel complex for glycine. Spermine 13-21 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 144-157