PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15982768-1	2005	Endogenous polyamines like spermine are known to have four distinct effects on recombinant N-methyl-d-aspartate (NMDA) receptor channels: voltage-dependent inhibition, glycine-dependent stimulation, glycine-independent stimulation and decreased affinity to the agonist (l-glutamate).	Spermine	27-35	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	91-127	
10347236-0	1999	A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein.	Spermine	99-107	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	57-86	
7534390-4	1994	Arcaine, a putative competitive antagonist at the polyamine-binding site on the N-methyl-D-aspartate (NMDA) receptor-channel complex, reduced the spermine enhancement of ACh-induced whole-cell currents.	Spermine	146-154	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	80-116	
8649353-0	1996	An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.	Spermine	108-116	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	54-83	
8161453-2	1994	NR1 subunits with an N-terminal insert (termed N1) form receptors in Xenopus oocytes with greatly reduced potentiation by spermine and Zn2+.	Spermine	122-130	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	0-3	
8161453-8	1994	The positively charged N1 may increase NMDA currents by causing a conformational change similar to that produced by spermine and Zn2+ in NR1 receptors lacking N1.	Spermine	116-124	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	137-140	
8341692-5	1993	NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine.	Spermine	185-193	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	0-3	
8341692-5	1993	NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine.	Spermine	185-193	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	47-50	
8341692-5	1993	NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine.	Spermine	185-193	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	47-50	
8341692-5	1993	NR1 receptors that lacked the N-terminal exon (NR1(000), NR1(010), and NR1(011)) exhibited a relatively high affinity for NMDA (EC50 approximately 13 microM) and marked potentiation by spermine.	Spermine	185-193	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	47-50	
8341692-6	1993	In contrast, those receptor variants with the N-terminal insert (NR1(100), NR1(101), and NR1(111)) showed a lower agonist affinity and little or no spermine potentiation at saturating glycine.	Spermine	148-156	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	65-68	
1838407-4	1991	These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex.	Spermine	163-171	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	102-115	
1838407-4	1991	These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex.	Spermine	163-171	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	213-226	
1702227-5	1990	Our results demonstrate that spermine potentiates the response of the NMDA receptor but has no effect on responses to kainate and quisqualate.	Spermine	29-37	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	70-83	
1702227-6	1990	Furthermore, spermine increases the maximum response to NMDA and glycine and acts, at least in part, by increasing the apparent affinity of the NMDA receptor/channel complex for glycine.	Spermine	13-21	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	144-157