PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11888912-7	2002	However, aphidicolin-synchronized HN12 cells released in the presence of perifosine (10 microM) demonstrated increased expression of total p21(WAF1) and increased association of p21(WAF1) with cyclin-cdk complexes resulting in reduced cdc2 activity.	Aphidicolin	9-20	cyclin dependent kinase 1	Homo sapiens	235-239	
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	93-97	
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	188-192	
1933864-8	1991	In contrast to senescent and low serum-arrested cells, cdc2 mRNA was expressed at normal levels in cells partially growth arrested by isoleucine deficiency in G1, by aphidicolin at G1-S, by etoposide in G2, or by Colcemid in the M phase of the cell cycle, indicating that cdc2 down-regulation does not always occur upon growth arrest.	Aphidicolin	166-177	cyclin dependent kinase 1	Homo sapiens	55-59	
1390903-4	1992	Cells arrested in late G1 by aphidicolin have abundant p58cyclin A and phosphorylated p34cdc2.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	86-93	
7937793-7	1994	Cells arrested in G2 phase following nitrogen mustard treatment or cells arrested in S phase with aphidicolin failed to dephosphorylate and activate cdc2, and this correlated with failure to convert cdc25C into the most active hyperphosphorylated species.	Aphidicolin	98-109	cyclin dependent kinase 1	Homo sapiens	149-153	
25732194-4	2015	Concomitant treatment of JT/Neo cells with 2-MeO-E2 and the G1/S blocking agent aphidicolin resulted in G1/S arrest and abrogation of all apoptotic events, including Cdk1 activation, phosphorylation of Bcl-2, Mcl-1 and Bim, and ROS accumulation.	Aphidicolin	80-91	cyclin dependent kinase 1	Homo sapiens	166-170