PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31597105-7	2019	SENP6 deficiency impairs chromatin association of the ATR cofactor ATRIP, thereby compromising the activation of Chk1 signaling in response to aphidicolin-induced replicative stress and sensitizing cells to DNA damage.	Aphidicolin	143-154	checkpoint kinase 1	Homo sapiens	113-117	
27634334-6	2016	Chemical and cytotoxic induction of replication stress, through aphidicolin, gemcitabine, camptothecin or hydroxyurea exposure, activates transcription of APOBEC3B via an ATR/Chk1-dependent pathway in vitro.	Aphidicolin	64-75	checkpoint kinase 1	Homo sapiens	175-179	
30657978-5	2019	We demonstrate that loss of WRN leads to enhanced ATM phosphorylation upon prolonged exposure to aphidicolin, a specific inhibitor of DNA polymerases, resulting in CHK1 activation.	Aphidicolin	97-108	checkpoint kinase 1	Homo sapiens	164-168	
17912033-8	2007	In aphidicolin-treated cells, there were lower levels of Serine 317-phosphorylated Chk1 when Plk2 was knocked-down.	Aphidicolin	3-14	checkpoint kinase 1	Homo sapiens	83-87	
21907702-5	2011	The mutation strongly attenuates aphidicolin induced Chk1 activation without altering the S-phase dependent Chk1 activation.	Aphidicolin	33-44	checkpoint kinase 1	Homo sapiens	53-57	
21212274-10	2011	In support of this hypothesis, DNA replication inhibitors such as hydroxyurea and aphidicolin similarly enhanced TAp73alpha expression and Chk1 phosphorylation.	Aphidicolin	82-93	checkpoint kinase 1	Homo sapiens	139-143	
16732333-5	2006	We demonstrate that both CHK1 and CHK2 are activated following treatment of cells with low doses of aphidicolin that induce fragile site breakage.	Aphidicolin	100-111	checkpoint kinase 1	Homo sapiens	25-29	
16828751-4	2006	In response to hydroxyurea, UV or aphidicolin, Claspin is phosphorylated in the Chk1-binding domain and its protein levels are increased in an ATR-dependent manner.	Aphidicolin	34-45	checkpoint kinase 1	Homo sapiens	80-84	
15538388-3	2004	In HeLa cells, depletion of either hRad17 or hMCM7 with small-interfering RNA suppressed ultraviolet (UV) light- or aphidicolin-induced hChk1 phosphorylation, and abolished UV-induced S-phase checkpoint activation.	Aphidicolin	116-127	checkpoint kinase 1	Homo sapiens	136-141	
14643438-3	2003	Treatment by aphidicolin and HU resulted in phosphorylation of Chk1, while HU, but not aphidicolin, induced focalization of gamma-H2AX and RPA.	Aphidicolin	13-24	checkpoint kinase 1	Homo sapiens	63-67