PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31280197-1 2019 BACKGROUND/AIM: Perinatal diethylstilbestrol (DES) treatment induces the polyovular follicle containing two or more oocytes in a follicle of mouse ovary through estrogen receptor (ER) beta. Diethylstilbestrol 26-44 estrogen receptor 2 (beta) Mus musculus 161-188 31280197-1 2019 BACKGROUND/AIM: Perinatal diethylstilbestrol (DES) treatment induces the polyovular follicle containing two or more oocytes in a follicle of mouse ovary through estrogen receptor (ER) beta. Diethylstilbestrol 46-49 estrogen receptor 2 (beta) Mus musculus 161-188 26944108-8 2016 The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes. Diethylstilbestrol 35-53 estrogen receptor 2 (beta) Mus musculus 242-248 29275294-1 2018 BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) beta, not ERalpha. Diethylstilbestrol 25-43 estrogen receptor 2 (beta) Mus musculus 155-182 29275294-1 2018 BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) beta, not ERalpha. Diethylstilbestrol 45-48 estrogen receptor 2 (beta) Mus musculus 155-182 26944108-8 2016 The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes. Diethylstilbestrol 55-58 estrogen receptor 2 (beta) Mus musculus 242-248 23653160-9 2013 Abnormalities observed in Arom+ and neonatally DES-treated mice correlate with the expression of estrogen receptor-beta (ERbeta) in the affected structures. Diethylstilbestrol 47-50 estrogen receptor 2 (beta) Mus musculus 97-119 23653160-9 2013 Abnormalities observed in Arom+ and neonatally DES-treated mice correlate with the expression of estrogen receptor-beta (ERbeta) in the affected structures. Diethylstilbestrol 47-50 estrogen receptor 2 (beta) Mus musculus 121-127 22275727-11 2012 CONCLUSIONS: These data suggest that DES-induced SV toxicity and feminization are primarily mediated by ERalpha; however, some aspects of androgen response may require the action of ERbeta. Diethylstilbestrol 37-40 estrogen receptor 2 (beta) Mus musculus 182-188 19553606-2 2009 We reported previously that the estrogen receptor beta (ESR2) mediates DES signaling in polyovular follicle induction. Diethylstilbestrol 71-74 estrogen receptor 2 (beta) Mus musculus 32-54 19553606-2 2009 We reported previously that the estrogen receptor beta (ESR2) mediates DES signaling in polyovular follicle induction. Diethylstilbestrol 71-74 estrogen receptor 2 (beta) Mus musculus 56-60 21783566-6 2005 Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta. Diethylstilbestrol 132-150 estrogen receptor 2 (beta) Mus musculus 62-68 19832683-0 2009 Involvement of estrogen receptor beta in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol. Diethylstilbestrol 118-136 estrogen receptor 2 (beta) Mus musculus 15-37 19832683-3 2009 In this study, the involvement of estrogen receptor subtypes ERalpha and ERbeta in induction of PFs by neonatal treatment with DES was analyzed by using ERalpha knockout (alphaERKO) and ERbeta knockout (betaERKO) mice. Diethylstilbestrol 127-130 estrogen receptor 2 (beta) Mus musculus 73-79 18835417-5 2008 Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively. Diethylstilbestrol 75-78 estrogen receptor 2 (beta) Mus musculus 47-53 18835417-5 2008 Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively. Diethylstilbestrol 75-78 estrogen receptor 2 (beta) Mus musculus 172-178 18835417-5 2008 Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively. Diethylstilbestrol 324-327 estrogen receptor 2 (beta) Mus musculus 172-178 18339713-11 2008 Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels. Diethylstilbestrol 167-170 estrogen receptor 2 (beta) Mus musculus 8-14 18339713-11 2008 Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels. Diethylstilbestrol 167-170 estrogen receptor 2 (beta) Mus musculus 229-235 19832683-8 2009 These results indicate that ERbeta but not ERalpha is essential for DES to Induce PFs in mice. Diethylstilbestrol 68-71 estrogen receptor 2 (beta) Mus musculus 28-34 16468032-4 2006 When the expression of estrogen receptor (ER) alpha and beta was assessed, an induction of ERbeta by DES was found predominantly in PRL cells. Diethylstilbestrol 101-104 estrogen receptor 2 (beta) Mus musculus 91-97 21783566-6 2005 Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta. Diethylstilbestrol 132-150 estrogen receptor 2 (beta) Mus musculus 230-236 21783566-6 2005 Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta. Diethylstilbestrol 152-155 estrogen receptor 2 (beta) Mus musculus 62-68 21783566-6 2005 Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta. Diethylstilbestrol 152-155 estrogen receptor 2 (beta) Mus musculus 230-236 11784006-4 2001 The alphaERKO provides the potential to expose DES actions mediated by the second known ER, ERbeta, and those that are ER-independent. Diethylstilbestrol 47-50 estrogen receptor 2 (beta) Mus musculus 92-98