PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33450726-10 2021 Protein analyses revealed elevated levels of HDL-resident ATGL (P = 0.003) and CEPT1 (P < 0.0001), which mediate critical steps of PCps production along the TAG-DAG-PC axis, in GCK-MODY relative to T2D. Diglycerides 161-164 patatin like phospholipase domain containing 2 Homo sapiens 58-62 34543623-8 2021 In vitro, the truncated ATGL variant demonstrated acyl-CoA-independent transacylation activity when diacylglycerol was offered as substrate, resulting in the formation of fatty acid as well as tri- and monoacylglycerol. Diglycerides 100-114 patatin like phospholipase domain containing 2 Homo sapiens 24-28 24440819-6 2014 Here we show that ATGL activity is inhibited by long-chain acyl-CoAs in a non-competitive manner, similar as previously shown for hormone-sensitive lipase (HSL), the rate-limiting enzyme for diglyceride breakdown in adipose tissue. Diglycerides 191-202 patatin like phospholipase domain containing 2 Homo sapiens 18-22 26350461-2 2015 Comparative gene identification-58 (CGI-58) stimulates the enzymatic activity of adipose triglyceride lipase (ATGL), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids. Diglycerides 158-173 patatin like phospholipase domain containing 2 Homo sapiens 81-108 26350461-2 2015 Comparative gene identification-58 (CGI-58) stimulates the enzymatic activity of adipose triglyceride lipase (ATGL), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids. Diglycerides 158-173 patatin like phospholipase domain containing 2 Homo sapiens 110-114 28456765-3 2017 It was further shown that the process of lipolysis of triacylglycerol to diacylglycerol and fatty acid is initiated by adipose triglyceride lipase and not by hormone sensitive lipase, responsible for hydrolysis of diacylglycerol to monoacyglycerol and fatty acid. Diglycerides 73-87 patatin like phospholipase domain containing 2 Homo sapiens 119-146 28456765-3 2017 It was further shown that the process of lipolysis of triacylglycerol to diacylglycerol and fatty acid is initiated by adipose triglyceride lipase and not by hormone sensitive lipase, responsible for hydrolysis of diacylglycerol to monoacyglycerol and fatty acid. Diglycerides 214-228 patatin like phospholipase domain containing 2 Homo sapiens 119-146 27155760-1 2016 Adipose Triglyceride Lipase (ATGL) performs the first and rate-limiting step in lipolysis by hydrolyzing triacylglycerols stored in lipid droplets to diacylglycerols. Diglycerides 150-165 patatin like phospholipase domain containing 2 Homo sapiens 0-27 27155760-1 2016 Adipose Triglyceride Lipase (ATGL) performs the first and rate-limiting step in lipolysis by hydrolyzing triacylglycerols stored in lipid droplets to diacylglycerols. Diglycerides 150-165 patatin like phospholipase domain containing 2 Homo sapiens 29-33 24440819-7 2014 ATGL activity is only marginally inhibited by medium-chain acyl-CoAs, diglycerides, monoglycerides, and free fatty acids. Diglycerides 70-82 patatin like phospholipase domain containing 2 Homo sapiens 0-4 20480242-1 2011 The adipose triglyceride lipase (PNPLA2, also known as ATGL) is a novel triacylglycerol (TG) lipase which specifically removes the first fatty acid from the triglyceride molecule generating free fatty acid and diglyceride (DG) in mammalian cells. Diglycerides 210-221 patatin like phospholipase domain containing 2 Homo sapiens 4-31 22829614-4 2012 It was identified as the co-activator of adipose triglyceride lipase (ATGL), which performs the first step in breaking down triacylglycerol and generating diacylglycerol and NEFA. Diglycerides 155-169 patatin like phospholipase domain containing 2 Homo sapiens 41-68 22829614-4 2012 It was identified as the co-activator of adipose triglyceride lipase (ATGL), which performs the first step in breaking down triacylglycerol and generating diacylglycerol and NEFA. Diglycerides 155-169 patatin like phospholipase domain containing 2 Homo sapiens 70-74 23066022-1 2012 Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. Diglycerides 121-135 patatin like phospholipase domain containing 2 Homo sapiens 0-27 23066022-1 2012 Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. Diglycerides 121-135 patatin like phospholipase domain containing 2 Homo sapiens 29-33 23066022-1 2012 Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. Diglycerides 137-140 patatin like phospholipase domain containing 2 Homo sapiens 0-27 23066022-1 2012 Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. Diglycerides 137-140 patatin like phospholipase domain containing 2 Homo sapiens 29-33 23066022-8 2012 Because ATGL preferentially generates sn-1,3 and sn-2,3, it suggests that TAG-derived DAG cannot directly enter phospholipid synthesis or activate protein kinase C without prior isomerization. Diglycerides 86-89 patatin like phospholipase domain containing 2 Homo sapiens 8-12 21498783-2 2011 DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL). Diglycerides 0-4 patatin like phospholipase domain containing 2 Homo sapiens 67-94 21498783-2 2011 DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL). Diglycerides 0-4 patatin like phospholipase domain containing 2 Homo sapiens 96-100 21498783-3 2011 We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance. Diglycerides 101-104 patatin like phospholipase domain containing 2 Homo sapiens 37-41 21498783-7 2011 We next showed that adenovirus-mediated ATGL overexpression in human primary myotubes induced DAG and ceramide accumulation. Diglycerides 94-97 patatin like phospholipase domain containing 2 Homo sapiens 40-44 21498783-11 2011 CONCLUSIONS: Altogether, the data indicate that altered ATGL and HSL expression in skeletal muscle could promote DAG accumulation and disrupt insulin signaling and action. Diglycerides 113-116 patatin like phospholipase domain containing 2 Homo sapiens 56-60 20480242-1 2011 The adipose triglyceride lipase (PNPLA2, also known as ATGL) is a novel triacylglycerol (TG) lipase which specifically removes the first fatty acid from the triglyceride molecule generating free fatty acid and diglyceride (DG) in mammalian cells. Diglycerides 210-221 patatin like phospholipase domain containing 2 Homo sapiens 33-39 20480242-1 2011 The adipose triglyceride lipase (PNPLA2, also known as ATGL) is a novel triacylglycerol (TG) lipase which specifically removes the first fatty acid from the triglyceride molecule generating free fatty acid and diglyceride (DG) in mammalian cells. Diglycerides 210-221 patatin like phospholipase domain containing 2 Homo sapiens 55-59 18357681-3 2008 ATGL expressed predominantly in white adipose tissue specifically initiates triacylglycerol hydrolysis to generate diacylglycerols and FFA, a role distinguished from HSL that mainly hydrolyzes diacylglycerols. Diglycerides 115-130 patatin like phospholipase domain containing 2 Homo sapiens 0-4 22039468-2 2011 ATGL specifically hydrolyzes triacylglycerols (TGs), thereby generating diacylglycerols and free fatty acids. Diglycerides 72-87 patatin like phospholipase domain containing 2 Homo sapiens 0-4 18445597-1 2008 Adipose triglyceride lipase (ATGL) catalyzes the first step in the hydrolysis of triacylglycerol (TG) generating diacylglycerol and free fatty acids. Diglycerides 113-127 patatin like phospholipase domain containing 2 Homo sapiens 0-27 18445597-1 2008 Adipose triglyceride lipase (ATGL) catalyzes the first step in the hydrolysis of triacylglycerol (TG) generating diacylglycerol and free fatty acids. Diglycerides 113-127 patatin like phospholipase domain containing 2 Homo sapiens 29-33 18357681-3 2008 ATGL expressed predominantly in white adipose tissue specifically initiates triacylglycerol hydrolysis to generate diacylglycerols and FFA, a role distinguished from HSL that mainly hydrolyzes diacylglycerols. Diglycerides 193-208 patatin like phospholipase domain containing 2 Homo sapiens 0-4 15971411-4 2005 Desnutrin functions by acting as the first enzyme in lipolysis, hydrolyzing triglycerides to diglycerides, whereas the well-known hormone-sensitive lipase takes the diglycerides to monoglycerides and on to free fatty acids. Diglycerides 93-105 patatin like phospholipase domain containing 2 Homo sapiens 0-9 15971411-4 2005 Desnutrin functions by acting as the first enzyme in lipolysis, hydrolyzing triglycerides to diglycerides, whereas the well-known hormone-sensitive lipase takes the diglycerides to monoglycerides and on to free fatty acids. Diglycerides 165-177 patatin like phospholipase domain containing 2 Homo sapiens 0-9