PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11786297-9 2001 Phosphoinositidase C was present in the nuclei and inhibitors of this enzyme did decrease PA formation, indicating diacylglycerols from inositides as substrates for nuclear diacylglycerol kinase. Diglycerides 115-130 phospholipase C beta 1 Homo sapiens 0-20 12799190-12 2003 We may speculate that nuclear speckle-located DGK-theta, on cell stimulation with an agonist, converts to PA the DAG derived from PLCbeta1-dependent PIP(2) hydrolysis. Diglycerides 113-116 phospholipase C beta 1 Homo sapiens 130-138 12237449-4 2002 Among these nuclear lipids are the polyphosphoinositol lipids which, together with the enzymes that synthesize them, form an intranuclear phospholipase C (PI-PLC) signaling system that generates diacylglycerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Diglycerides 195-209 phospholipase C beta 1 Homo sapiens 155-161 12237449-4 2002 Among these nuclear lipids are the polyphosphoinositol lipids which, together with the enzymes that synthesize them, form an intranuclear phospholipase C (PI-PLC) signaling system that generates diacylglycerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Diglycerides 211-214 phospholipase C beta 1 Homo sapiens 155-161 8897825-6 1996 Addition of PI-specific PLC (PI-PLC) to [3H]arachidonate-labeled A10 cells resulted in a modest increase in radiolabeled DAG that was also hydrolyzed to MG and FA. Diglycerides 121-124 phospholipase C beta 1 Homo sapiens 12-27 11606452-7 2001 PLC beta 1 and PLC beta 3 are expressed in GT1 neurons, and these PLCs are probably responsible for the release of diacylglycerol and IP as well as the increase in intracellular calcium. Diglycerides 115-129 phospholipase C beta 1 Homo sapiens 0-10 11087348-10 2000 However, when diacylglycerol is included in the bilayers containing 5 mol % PI, PI-PLC activity leads to complete fusion. Diglycerides 14-28 phospholipase C beta 1 Homo sapiens 80-86 9006988-7 1997 Partial amino acid sequencing reveals that the Cat-307 protein is phospholipase C-beta1, the G-protein-dependent phosphodiesterase that hydrolyses phosphatidylinositol 4,5 biphosphate into inositol 1,4,5 triphosphate and diacylglycerol after the stimulation of a variety of neurotransmitter receptors at the cell surface. Diglycerides 221-235 phospholipase C beta 1 Homo sapiens 66-87 21340820-9 2001 Phosphatidylinositol-specific phospholipase C(PI-PLC) is the rate-limiting enzyme of PI turnover (1), and catalyzes the hydrolysis of PI-4,5-P(2) to produce two second messengers, inositol 1,4,5-trisphosphate (IP(3)) and DAG. Diglycerides 221-224 phospholipase C beta 1 Homo sapiens 46-52 11752607-4 2000 Among these nuclear lipids are the polyphosphoinositol lipids which, together with the enzymes that synthesize them, form an intranuclear phospholipase C (PI-PLC) signaling system that generates diacylglycerol and inositol-1,4,5-trisphosphate [Ins(1,4,5)P(3)]. Diglycerides 195-209 phospholipase C beta 1 Homo sapiens 155-161 9334202-9 1997 Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation. Diglycerides 306-309 phospholipase C beta 1 Homo sapiens 61-106 9334202-9 1997 Nuclear phospholipase activity is inhibited by the selective phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and neomycin sulfate, but not by the phosphatidylcholine-PLC selective inhibitor D609 or inhibitors of phospholipase D-mediated DAG generation. Diglycerides 306-309 phospholipase C beta 1 Homo sapiens 108-114 9334202-11 1997 Our data are consistent with the hypothesis that nuclear PI-PLC generates DAG to activate nuclear betaII PKC, whose activity is required for mitosis. Diglycerides 74-77 phospholipase C beta 1 Homo sapiens 57-63 9293962-1 1997 It is generally accepted that in endothelial cells the occupation of bradykinin B2 receptors, which are linked to the guanine nucleotide-dependent regulatory proteins, Gi and Gq, results in the activation of phospholipase C-beta1 (PLC-beta1), followed by a transient increase in the formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. Diglycerides 335-349 phospholipase C beta 1 Homo sapiens 208-229 9293962-1 1997 It is generally accepted that in endothelial cells the occupation of bradykinin B2 receptors, which are linked to the guanine nucleotide-dependent regulatory proteins, Gi and Gq, results in the activation of phospholipase C-beta1 (PLC-beta1), followed by a transient increase in the formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. Diglycerides 335-349 phospholipase C beta 1 Homo sapiens 231-240 8897825-6 1996 Addition of PI-specific PLC (PI-PLC) to [3H]arachidonate-labeled A10 cells resulted in a modest increase in radiolabeled DAG that was also hydrolyzed to MG and FA. Diglycerides 121-124 phospholipase C beta 1 Homo sapiens 29-35 8897825-7 1996 Therefore, the principal metabolic fate of endogenous DAG generated from membrane phospholipids by treatment of A10 cells with PC-PLC and PI-PLC was hydrolysis by a DAG lipase pathway. Diglycerides 54-57 phospholipase C beta 1 Homo sapiens 138-144 24076015-2 2014 In neuronal cells of adult brain, the standard model proposes that activation of metabotropic receptors coupled to Phospholipase C-beta1 (PLC-beta1) is linked to endocannabinoid signaling through the production of diacylglycerol (DAG), which could be systematically metabolized by 1,2-diacylglycerol Lipases (DAGL) to produce an increase of 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in the brain. Diglycerides 230-233 phospholipase C beta 1 Homo sapiens 115-136 8602259-1 1996 Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. Diglycerides 165-179 phospholipase C beta 1 Homo sapiens 61-67 7651363-12 1995 We conclude that DAG formation in intestinal muscle is mediated by time-dependent activation of three phospholipases (PI-PLC, PC-PLC, and PLD) and two converting enzymes (DAG kinase and PPH). Diglycerides 17-20 phospholipase C beta 1 Homo sapiens 118-124 8717070-4 1996 Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of peptide. Diglycerides 129-143 phospholipase C beta 1 Homo sapiens 15-60 8717070-4 1996 Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of peptide. Diglycerides 129-143 phospholipase C beta 1 Homo sapiens 62-68 8371057-3 1993 Activation of alpha 1-adrenoceptors stimulates phosphoinositidase C activity leading to inositol 1,4,5-triphosphate and diacylglycerol formation with a consequent mobilization of intracellular Ca2+ stores and protein kinase C activation which trigger cell responsiveness. Diglycerides 120-134 phospholipase C beta 1 Homo sapiens 47-67 29610273-1 2018 G protein-coupled receptors that signal through Galphaq (Gq receptors), such as alpha1-adrenergic receptors (alpha1-ARs) or angiotensin receptors, share a common proximal signaling pathway that activates phospholipase Cbeta1 (PLCbeta1), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) to produce inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. Diglycerides 346-360 phospholipase C beta 1 Homo sapiens 226-234 25362646-5 2014 Moreover, the process resulted to be strictly connected with the increase in nuclear diacylglycerol levels (DAG) at G2/M checkpoint, due to the activity of nuclear Phospholipase C beta1 (PLCbeta1), the only PLC isoform mainly localized in the nucleus of K562 cells. Diglycerides 85-99 phospholipase C beta 1 Homo sapiens 164-185 25362646-5 2014 Moreover, the process resulted to be strictly connected with the increase in nuclear diacylglycerol levels (DAG) at G2/M checkpoint, due to the activity of nuclear Phospholipase C beta1 (PLCbeta1), the only PLC isoform mainly localized in the nucleus of K562 cells. Diglycerides 85-99 phospholipase C beta 1 Homo sapiens 187-195 23856562-1 2014 Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3). Diglycerides 145-159 phospholipase C beta 1 Homo sapiens 0-41 23856562-1 2014 Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3). Diglycerides 145-159 phospholipase C beta 1 Homo sapiens 43-49 23856562-1 2014 Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3). Diglycerides 161-164 phospholipase C beta 1 Homo sapiens 0-41 23856562-1 2014 Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3). Diglycerides 161-164 phospholipase C beta 1 Homo sapiens 43-49 24076015-2 2014 In neuronal cells of adult brain, the standard model proposes that activation of metabotropic receptors coupled to Phospholipase C-beta1 (PLC-beta1) is linked to endocannabinoid signaling through the production of diacylglycerol (DAG), which could be systematically metabolized by 1,2-diacylglycerol Lipases (DAGL) to produce an increase of 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in the brain. Diglycerides 230-233 phospholipase C beta 1 Homo sapiens 138-147 17981726-4 2008 Some of these pathways are well established, such as that of PI-specific phospholipase C (PI-PLC), which cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the two second messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3). Diglycerides 189-203 phospholipase C beta 1 Homo sapiens 61-88 22800439-3 2013 Once activated, PI-PLC cleaves an important membrane PI, the phosphatidylinositol (4,5) bisphosphate into inositol trisphosphate and diacylglycerol-both are crucial molecules in the transduction of signals. Diglycerides 133-147 phospholipase C beta 1 Homo sapiens 16-22 17981726-4 2008 Some of these pathways are well established, such as that of PI-specific phospholipase C (PI-PLC), which cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the two second messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3). Diglycerides 189-203 phospholipase C beta 1 Homo sapiens 90-96 17981726-4 2008 Some of these pathways are well established, such as that of PI-specific phospholipase C (PI-PLC), which cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the two second messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3). Diglycerides 205-208 phospholipase C beta 1 Homo sapiens 61-88 17981726-4 2008 Some of these pathways are well established, such as that of PI-specific phospholipase C (PI-PLC), which cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the two second messengers diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3). Diglycerides 205-208 phospholipase C beta 1 Homo sapiens 90-96