PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25682201-3	2015	RasGRP3, an important signaling protein responsive to diacylglycerol (DAG), increases Ras activation.	Diglycerides	54-68	RAS guanyl releasing protein 3	Homo sapiens	0-7	
11689073-8	2001	NSC 631939 and NSC 631941 bound to RasGRP3, a phorbol ester receptor that directly links diacylglycerol/phorbol ester signaling with Ras activation, with K(i) values of 15.5 +/- 2.3 and 41.7 +/- 6.5 nM, respectively.	Diglycerides	89-103	RAS guanyl releasing protein 3	Homo sapiens	35-42	
11221888-7	2001	Finally, both phorbol 12-myristate 13-acetate and the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol induced redistribution of RasGRP3 to the plasma membrane and/or perinuclear area in HEK-293 cells, as demonstrated using a green fluorescent fusion protein.	Diglycerides	54-68	RAS guanyl releasing protein 3	Homo sapiens	131-138	
10934204-7	2000	A third GEF, GRP3 (KIAA0846), activated both Ras and Rap1 and shared significant sequence homology with the calcium- and diacylglycerol-activated GEFs, GRP1 and GRP2.	Diglycerides	121-135	RAS guanyl releasing protein 3	Homo sapiens	13-17	
25682201-3	2015	RasGRP3, an important signaling protein responsive to diacylglycerol (DAG), increases Ras activation.	Diglycerides	70-73	RAS guanyl releasing protein 3	Homo sapiens	0-7	
17012239-1	2006	RasGRP3 is an exchange factor for Ras-like small GTPases that is activated in response to the second messenger diacylglycerol.	Diglycerides	111-125	RAS guanyl releasing protein 3	Homo sapiens	0-7	
19700408-3	2009	Ras activation was associated with the recruitment of RasGRP3, a diacylglycerol-dependent Ras/Rap1 exchange factor.	Diglycerides	65-79	RAS guanyl releasing protein 3	Homo sapiens	54-61	
19700408-4	2009	Recruitment to phagosomes of RasGRP3, which contains a C1 domain, parallels and appears to be due to the formation of diacylglycerol.	Diglycerides	118-132	RAS guanyl releasing protein 3	Homo sapiens	29-36	
17523924-6	2007	In cells, the isolated C1 domains of RasGRP1, RasGRP3 and RasGRP4alpha co-localize with membranes and relocalize in response to DAG, whereas the C1 domains of RasGRP2 and RasGRP4beta do not.	Diglycerides	128-131	RAS guanyl releasing protein 3	Homo sapiens	46-53	
17523924-7	2007	Only the C1 domains of RasGRP1, RasGRP3 and RasGRP4alpha recognize DAG as a ligand within phospholipid vesicles and do so with differential affinities.	Diglycerides	67-70	RAS guanyl releasing protein 3	Homo sapiens	32-39	
17012239-2	2006	As with other diacylglycerol receptors, RasGRP3 is redistributed upon diacylglycerol or phorbol ester binding.	Diglycerides	14-28	RAS guanyl releasing protein 3	Homo sapiens	40-47	
17012239-9	2006	These findings suggest that dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor and, as such, may participate in the signaling mediated by diacylglycerol through RasGRP3.	Diglycerides	223-237	RAS guanyl releasing protein 3	Homo sapiens	90-97	
17012239-9	2006	These findings suggest that dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor and, as such, may participate in the signaling mediated by diacylglycerol through RasGRP3.	Diglycerides	223-237	RAS guanyl releasing protein 3	Homo sapiens	246-253	
15572660-5	2004	Phorbol esters mimic the second messenger diacylglycerol (DAG) in activating both protein kinase C (PKC) and non-PKC phorbol ester receptors such as RasGRP3.	Diglycerides	42-56	RAS guanyl releasing protein 3	Homo sapiens	149-156	
15657177-6	2005	Antiphosphopeptide antibodies recognize Thr133-phosphorylated RasGRP3 in B cells after BCR stimulation or DAG analog treatment, but much less so in resting cells.	Diglycerides	106-109	RAS guanyl releasing protein 3	Homo sapiens	62-69	
15737652-4	2005	Nowadays members of the RasGRP family are being identified as novel molecules binding to diacylglycerol and calcium, representing a new class of guanine nucleotide exchange factor that activates small GTPases including Ras and Rap1.	Diglycerides	89-103	RAS guanyl releasing protein 3	Homo sapiens	24-30	
15572660-5	2004	Phorbol esters mimic the second messenger diacylglycerol (DAG) in activating both protein kinase C (PKC) and non-PKC phorbol ester receptors such as RasGRP3.	Diglycerides	58-61	RAS guanyl releasing protein 3	Homo sapiens	149-156	
15572660-9	2004	This suggests that RasGRP3 activity may exacerbate vascular complications in diseases characterized by excess DAG, such as diabetes.	Diglycerides	110-113	RAS guanyl releasing protein 3	Homo sapiens	19-26	
15143162-5	2004	Expression of RasGRP3, a Ca(2+)/diacylglycerol-regulated guanine nucleotide exchange factor for Ras-like GTPases, but not expression of various other exchange factors enhanced GTP loading of Rap2B and PLC/Ca(2+) signaling by the EGF receptor.	Diglycerides	32-46	RAS guanyl releasing protein 3	Homo sapiens	14-21	
15545601-6	2004	Hence, our data suggest that PKC, after being activated by diacylglycerol, phosphorylates RasGRP3, thereby contributing to its full activation.	Diglycerides	59-73	RAS guanyl releasing protein 3	Homo sapiens	90-97	
12730099-0	2003	Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.	Diglycerides	15-18	RAS guanyl releasing protein 3	Homo sapiens	82-89	
12730099-4	2003	Indeed, stimulation of Ramos B cells with the DAG analog phorbol ester myristate (PMA) results in the association of RasGRP3 with the membrane fraction.	Diglycerides	46-49	RAS guanyl releasing protein 3	Homo sapiens	117-124