PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3036701-3 1987 Sequential phospholipase C-mediated hydrolysis of the polyphosphoinositides and phosphatidylinositol in cultured vascular smooth muscle cells stimulated with angiotensin II results in a coordinated series of biochemical events: a transient formation of inositol trisphosphate associated with calcium mobilization, and a biphasic, sustained formation of diacylglycerol associated with activation of protein kinase C and cytosolic alkalinization. Diglycerides 353-367 angiotensinogen Homo sapiens 158-172 2673302-2 1989 Activation of vascular smooth muscle by angiotensin II results in the phospholipase C-mediated generation of two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DG). Diglycerides 165-179 angiotensinogen Homo sapiens 40-54 3135214-4 1988 The diacylglycerol lipase inhibitor RHC80267 decreased AII-stimulated prolactin release and arachidonate liberation. Diglycerides 4-18 angiotensinogen Homo sapiens 55-58 2826275-3 1987 The present study demonstrates that PMA and DAG augment prolactin release and attenuate the elevations of inositol phosphates (IPX) elicited by thyrotropin-releasing hormone (TRH), angiotensin II, neurotensin, bombesin and gonadotropin-releasing hormone (GnRH) in normal anterior pituitary and prolactin-secreting 7315a tumor cells. Diglycerides 44-47 angiotensinogen Homo sapiens 181-195 2692509-12 1989 Yet different molecules (cAMP, calcium, inositol phosphates, diacyl-glycerol) trigger the hormonal effect of angiotensin II inside the cell. Diglycerides 61-76 angiotensinogen Homo sapiens 109-123 2478821-2 1989 One of the earliest documented events following incubation of these cells with Ang II is the rapid, phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate to yield two second messengers, inositol trisphosphate and diacylglycerol. Diglycerides 236-250 angiotensinogen Homo sapiens 79-85 2478821-3 1989 Inositol trisphosphate releases calcium from nonmitochondrial intracellular storage sites, while diacylglycerol activates protein kinase C. Ang II also stimulates calcium influx and increases calcium efflux for the duration of the stimulus, as well as causing a biphasic change in intracellular pH. Diglycerides 97-111 angiotensinogen Homo sapiens 140-146 2847716-0 1988 Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis. Diglycerides 0-14 angiotensinogen Homo sapiens 80-94 2847716-5 1988 These results suggest that AA derived from diacylglycerol is the precursor of 12-hydroxyeicosatetraenoic involved in angiotensin II-induced aldosterone secretion. Diglycerides 43-57 angiotensinogen Homo sapiens 117-131 3078271-2 1988 Activation of vascular smooth muscle by angiotensin II results in the generation of two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DG). Diglycerides 140-154 angiotensinogen Homo sapiens 40-54 3036701-5 1987 Formation of inositol trisphosphate and mobilization of calcium are attenuated by activation of protein kinase C. Sustained diacylglycerol formation is promoted by cytosolic alkalinization, and appears to require cellular processing of the angiotensin II-receptor complex. Diglycerides 124-138 angiotensinogen Homo sapiens 240-254 17008309-0 2006 G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. Diglycerides 130-144 angiotensinogen Homo sapiens 84-98 19324408-5 2009 Optimal activation of a native TRPC6 ROC by angiotensin II (Ang II) requires both depletion of PIP(2) and generation of DAG which leads to stimulation of TRPC6 via a PKC-independent mechanism. Diglycerides 120-123 angiotensinogen Homo sapiens 44-58 19324408-5 2009 Optimal activation of a native TRPC6 ROC by angiotensin II (Ang II) requires both depletion of PIP(2) and generation of DAG which leads to stimulation of TRPC6 via a PKC-independent mechanism. Diglycerides 120-123 angiotensinogen Homo sapiens 60-66 20161229-3 2009 These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG). Diglycerides 350-364 angiotensinogen Homo sapiens 125-139 20161229-3 2009 These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG). Diglycerides 350-364 angiotensinogen Homo sapiens 184-198 20161229-3 2009 These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG). Diglycerides 366-369 angiotensinogen Homo sapiens 125-139 20161229-3 2009 These intracellular effectors will be the subject of this brief review on contractile activity initiated by endothelin-1 and angiotensin II.Activation of receptors by endothelin-1 and angiotensin II in smooth muscle cells results in phopholipase C (PLC) activation leading to the generation of the second messengers insitol trisphosphate (IP(3)) and diacylglycerol (DAG). Diglycerides 366-369 angiotensinogen Homo sapiens 184-198 6238962-2 1984 In the present study, it was shown that AII induces the rapid (10 s) hydrolysis of phosphatidylinositol 4-phosphate and -4,5-bisphosphate, leading to the sustained production of inositol bis- and trisphosphate (Ins-P3), and diacylglycerol rich in arachidonic acid. Diglycerides 224-238 angiotensinogen Homo sapiens 40-43 18948082-1 2008 The heterotrimeric guanine nucleotide-binding protein Galphaq transduces signals from heptahelical transmembrane receptors (e.g., alpha(1)-adrenergic, endothelin 1A, and angiotensin II) to stimulate generation of inositol-1,4,5-trisphosphate and diacylglycerol. Diglycerides 246-260 angiotensinogen Homo sapiens 170-184 17008309-3 2006 Here, we used a fluorescence resonance energy transfer-based live cell assay for the second messenger diacylglycerol to measure desensitization of a model seven-transmembrane receptor, the Gq-coupled angiotensin II type 1(A) receptor, expressed in human embryonic kidney 293 cells. Diglycerides 102-116 angiotensinogen Homo sapiens 200-214 17008309-4 2006 In response to angiotensin II, we observed a transient diacylglycerol response reflecting activation and complete desensitization of the receptor within 2-5 min. Diglycerides 55-69 angiotensinogen Homo sapiens 15-29 16461926-2 2006 The aim of the present work was to evaluate the implication of DAG-dependent PKCs in the activation of p44/42 MAP kinase (MAPK) by angiotensin II (Ang II) and to define the role of this pathway towards CYP11B2 regulation in H295R cells. Diglycerides 63-66 angiotensinogen Homo sapiens 131-145 16461926-2 2006 The aim of the present work was to evaluate the implication of DAG-dependent PKCs in the activation of p44/42 MAP kinase (MAPK) by angiotensin II (Ang II) and to define the role of this pathway towards CYP11B2 regulation in H295R cells. Diglycerides 63-66 angiotensinogen Homo sapiens 147-153 9279776-8 1997 Thus, either one of the Ang II-induced second messengers, that is, IP3 and DAG, has the potential to affect myocardial contractility by modifying either intracellular Ca2+, myofilament Ca2+ responsiveness, or both. Diglycerides 75-78 angiotensinogen Homo sapiens 24-30 11818507-5 2002 By using selective agonists and inhibitors, we demonstrated that PLC and its derived signaling molecules, phosphatidylinositol triphosphate/Ca(2+) and diacylglycerol/PKC, were essential for AngII-induced JAK2 phosphorylation. Diglycerides 151-165 angiotensinogen Homo sapiens 190-195 9888517-2 1998 According to classic studies, Ang II and AVP activate phospholipase C (PLC), diacylglycerol (DAG) and inositol phosphate (InsPs) production whereas ACTH activates cAMP production. Diglycerides 77-91 angiotensinogen Homo sapiens 30-36 9888517-2 1998 According to classic studies, Ang II and AVP activate phospholipase C (PLC), diacylglycerol (DAG) and inositol phosphate (InsPs) production whereas ACTH activates cAMP production. Diglycerides 93-96 angiotensinogen Homo sapiens 30-36 15044681-8 2004 Activation of protein kinase C by diacylglycerol (DAG) inhibits aldosterone production, whereas the arachidonate released from DAG in ANG II-stimulated cells is converted by lipoxygenase to 12-hydroxyeicosatetraenoic acid, which may also induce Ca(2+) signaling. Diglycerides 127-130 angiotensinogen Homo sapiens 134-140 9520514-2 1998 These actions are mediated through angiotensin II receptors (AT1 subtype), which activate several G-protein-dependent intracellular transduction pathways, such as the phospholipase C, diacylglycerol and inositol trisphosphate the mitogen-activated protein (MAP) kinase pathway, and Janus kinase (JAK)-signal transducers and activators of the transcription (STAT)-mediated pathway. Diglycerides 184-198 angiotensinogen Homo sapiens 35-49 8238300-10 1993 Whereas downregulation prevented PLD-mediated PEt elevation, ANG II-stimulated DAG formation in myristate-labeled cells was unaltered, indicating PC-PLC activation. Diglycerides 79-82 angiotensinogen Homo sapiens 61-67 8837552-2 1996 These actions are mediated through angiotensin II receptors (subtype AT1), which activate the G protein, phospholipase C, diacylglycerol and inositol trisphosphate pathway, to increase the expression of certain protooncogenes (c-fos, c-myc and c-jun) and growth factors (platelet-derived growth factor-A-chain, transforming growth factor-beta 1 and basic fibroblast growth factor). Diglycerides 122-136 angiotensinogen Homo sapiens 35-49 8238300-1 1993 Angiotensin II (ANG II) in mesangial cells (MC) promotes phosphatidylinositol (PI) hydrolysis resulting in diacylglycerol (DAG)-mediated increases in protein kinase C (PKC) activity. Diglycerides 107-121 angiotensinogen Homo sapiens 0-14 8238300-1 1993 Angiotensin II (ANG II) in mesangial cells (MC) promotes phosphatidylinositol (PI) hydrolysis resulting in diacylglycerol (DAG)-mediated increases in protein kinase C (PKC) activity. Diglycerides 107-121 angiotensinogen Homo sapiens 16-22 8238300-1 1993 Angiotensin II (ANG II) in mesangial cells (MC) promotes phosphatidylinositol (PI) hydrolysis resulting in diacylglycerol (DAG)-mediated increases in protein kinase C (PKC) activity. Diglycerides 123-126 angiotensinogen Homo sapiens 0-14 8238300-1 1993 Angiotensin II (ANG II) in mesangial cells (MC) promotes phosphatidylinositol (PI) hydrolysis resulting in diacylglycerol (DAG)-mediated increases in protein kinase C (PKC) activity. Diglycerides 123-126 angiotensinogen Homo sapiens 16-22 8238300-5 1993 ANG II-mediated PC hydrolysis augmented DAG for 30 min. Diglycerides 40-43 angiotensinogen Homo sapiens 0-6 8238300-13 1993 ANG II mediated PC breakdown principally via PC-PLC provides a mechanism for maintaining elevated DAG levels and PKC activation. Diglycerides 98-101 angiotensinogen Homo sapiens 0-6 8399984-1 1993 In cultured vascular smooth muscle cells, angiotensin II and endothelin stimulate a variety of intracellular signals, including generation of inositol trisphosphate and diacylglycerol, mobilization of intracellular calcium, and activation of protein kinase C. These latter two events have been shown to mediate the phosphorylation of numerous proteins, but these substrates and the specific pathways mediating their phosphorylation have not been identified in vascular smooth muscle. Diglycerides 169-183 angiotensinogen Homo sapiens 42-56 8503884-0 1993 Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells. Diglycerides 63-77 angiotensinogen Homo sapiens 81-95 8503884-1 1993 In cultured vascular smooth-muscle cells, angiotensin II produces a sustained formation of diacylglycerol (DG) and phosphatidic acid (PtdOH). Diglycerides 91-105 angiotensinogen Homo sapiens 42-56 1903932-2 1991 In cultured vascular smooth-muscle cells (VSMC), angiotensin II (AngII) induces a biphasic, sustained increase in diacylglycerol (DG) of unclear origin. Diglycerides 114-128 angiotensinogen Homo sapiens 49-63 1417822-0 1992 Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells. Diglycerides 0-14 angiotensinogen Homo sapiens 53-67 1417822-1 1992 In cultured vascular smooth muscle cells (VSMC), angiotensin II (Ang II) induces a biphasic diacylglycerol (DAG) formation peaking at 15 sec and 5 min. Diglycerides 92-106 angiotensinogen Homo sapiens 49-63 1417822-1 1992 In cultured vascular smooth muscle cells (VSMC), angiotensin II (Ang II) induces a biphasic diacylglycerol (DAG) formation peaking at 15 sec and 5 min. Diglycerides 92-106 angiotensinogen Homo sapiens 65-71 1417822-1 1992 In cultured vascular smooth muscle cells (VSMC), angiotensin II (Ang II) induces a biphasic diacylglycerol (DAG) formation peaking at 15 sec and 5 min. Diglycerides 108-111 angiotensinogen Homo sapiens 49-63 1417822-1 1992 In cultured vascular smooth muscle cells (VSMC), angiotensin II (Ang II) induces a biphasic diacylglycerol (DAG) formation peaking at 15 sec and 5 min. Diglycerides 108-111 angiotensinogen Homo sapiens 65-71 1516268-9 1992 Stimulation of this exchanger may also occur due to AII-receptor activation of phospholipase C to release diacyl glycerol, or by local transduction in the brush-border membrane involving phospholipase A2. Diglycerides 106-121 angiotensinogen Homo sapiens 52-55 1404242-2 1992 Angiotensin II is known to elicit receptor-mediated stimulation of diacylglycerol (DAG) production in pulmonary artery endothelial cells. Diglycerides 67-81 angiotensinogen Homo sapiens 0-14 1404242-2 1992 Angiotensin II is known to elicit receptor-mediated stimulation of diacylglycerol (DAG) production in pulmonary artery endothelial cells. Diglycerides 83-86 angiotensinogen Homo sapiens 0-14 1903932-2 1991 In cultured vascular smooth-muscle cells (VSMC), angiotensin II (AngII) induces a biphasic, sustained increase in diacylglycerol (DG) of unclear origin. Diglycerides 114-128 angiotensinogen Homo sapiens 65-70