PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16248777-3 2005 Through these, ET-1 binding to ET(A)-receptors stimulates the hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate to diacylglycerol and inositol 1,4,5-trisphosphate. Diglycerides 126-140 endothelin 1 Rattus norvegicus 15-19 16311906-4 2005 The biological actions of ET-1 have been shown to be coupled to the hydrolysis of phosphotidylinositol 4,5-biphosphate and phosphotidylcholine and the subsequent production of diacylglycerol (DAG). Diglycerides 176-190 endothelin 1 Rattus norvegicus 26-30 16311906-4 2005 The biological actions of ET-1 have been shown to be coupled to the hydrolysis of phosphotidylinositol 4,5-biphosphate and phosphotidylcholine and the subsequent production of diacylglycerol (DAG). Diglycerides 192-195 endothelin 1 Rattus norvegicus 26-30 17208990-1 2007 The phosphatidylinositol (PI) signaling pathway mediates norepinephrine (NE)- and endothelin-1 (ET-1)-stimulated vascular smooth muscle contraction through an inositol-trisphosphate-induced rise in intracellular calcium and diacylglycerol (DG) activation of protein kinase C (PKC). Diglycerides 224-238 endothelin 1 Rattus norvegicus 82-94 17208990-1 2007 The phosphatidylinositol (PI) signaling pathway mediates norepinephrine (NE)- and endothelin-1 (ET-1)-stimulated vascular smooth muscle contraction through an inositol-trisphosphate-induced rise in intracellular calcium and diacylglycerol (DG) activation of protein kinase C (PKC). Diglycerides 224-238 endothelin 1 Rattus norvegicus 96-100 12055094-6 2002 These results suggest that both diacylglycerol-sensitive PKC, activated by PLC products, and diacylglycerol-insensitive PKC, possibly activated by a G(i)-PI 3-kinase-dependent process, are involved in ET-1-induced ERK activation. Diglycerides 32-46 endothelin 1 Rattus norvegicus 201-205 15781737-1 2005 BACKGROUND: Diacylglycerol (DAG) is a lipid second messenger that transiently accumulates in cells stimulated by endothelin-1 (ET-1) and other Galphaq protein-coupled receptor agonists. Diglycerides 12-26 endothelin 1 Rattus norvegicus 113-125 15781737-1 2005 BACKGROUND: Diacylglycerol (DAG) is a lipid second messenger that transiently accumulates in cells stimulated by endothelin-1 (ET-1) and other Galphaq protein-coupled receptor agonists. Diglycerides 12-26 endothelin 1 Rattus norvegicus 127-131 15781737-1 2005 BACKGROUND: Diacylglycerol (DAG) is a lipid second messenger that transiently accumulates in cells stimulated by endothelin-1 (ET-1) and other Galphaq protein-coupled receptor agonists. Diglycerides 28-31 endothelin 1 Rattus norvegicus 113-125 15781737-1 2005 BACKGROUND: Diacylglycerol (DAG) is a lipid second messenger that transiently accumulates in cells stimulated by endothelin-1 (ET-1) and other Galphaq protein-coupled receptor agonists. Diglycerides 28-31 endothelin 1 Rattus norvegicus 127-131 15781737-3 2005 Because DGK inactivates DAG, a strong activator of protein kinase C (PKC), we hypothesized that DGK inhibited ET-1-induced activation of a DAG-PKC signaling cascade and subsequent cardiomyocyte hypertrophy. Diglycerides 24-27 endothelin 1 Rattus norvegicus 110-114 15781737-3 2005 Because DGK inactivates DAG, a strong activator of protein kinase C (PKC), we hypothesized that DGK inhibited ET-1-induced activation of a DAG-PKC signaling cascade and subsequent cardiomyocyte hypertrophy. Diglycerides 139-142 endothelin 1 Rattus norvegicus 110-114 15781737-11 2005 DGK-zeta might act as a negative regulator of hypertrophic program in response to ET-1, possibly by controlling cellular DAG levels. Diglycerides 121-124 endothelin 1 Rattus norvegicus 82-86 12821678-0 2003 High glucose-suppressed endothelin-1 Ca2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells. Diglycerides 74-88 endothelin 1 Rattus norvegicus 24-36 12055094-6 2002 These results suggest that both diacylglycerol-sensitive PKC, activated by PLC products, and diacylglycerol-insensitive PKC, possibly activated by a G(i)-PI 3-kinase-dependent process, are involved in ET-1-induced ERK activation. Diglycerides 93-107 endothelin 1 Rattus norvegicus 201-205 9007683-6 1997 ET-1 is known to be an activator of phosphoinositide hydrolysis, resulting in an increased production of IP3 and diacylglycerol (DAG). Diglycerides 113-127 endothelin 1 Rattus norvegicus 0-4 10050072-7 1999 In contrast, DAG levels, measured by [3H]myristate labelling and mass assay, increased transiently at 5 min of ET-1 stimulation only. Diglycerides 13-16 endothelin 1 Rattus norvegicus 111-115 10050072-9 1999 The PC-PLC inhibitor D609, 2.5 microg/ml, completely abolished the ET-1-induced increase in [14C]DAG without affecting the increase in [14C]PA, PLD activity or the contractile response. Diglycerides 97-100 endothelin 1 Rattus norvegicus 67-71 10050072-12 1999 The tyrosine kinase inhibitor tyrphostin A23 (100 microM) abolished ET-1-induced [3H]PA, [3H]PEt and [14C]DAG increases, whilst the negative analogue A1 was without effect. Diglycerides 106-109 endothelin 1 Rattus norvegicus 68-72 9644111-0 1998 Diacylglycerol molecular species in plasma membrane and microsomes change transiently with endothelin-1 treatment of glioma cells. Diglycerides 0-14 endothelin 1 Rattus norvegicus 91-103 9644111-2 1998 Using either DAG kinase or HPLC assays to quantitatively determine DAG mass, we observed a time-dependent increase in DAG accumulation upon incubation of rat C6 glioma cells with 200 nM endothelin-1 (ET-1). Diglycerides 13-16 endothelin 1 Rattus norvegicus 186-198 9644111-2 1998 Using either DAG kinase or HPLC assays to quantitatively determine DAG mass, we observed a time-dependent increase in DAG accumulation upon incubation of rat C6 glioma cells with 200 nM endothelin-1 (ET-1). Diglycerides 67-70 endothelin 1 Rattus norvegicus 186-198 9644111-2 1998 Using either DAG kinase or HPLC assays to quantitatively determine DAG mass, we observed a time-dependent increase in DAG accumulation upon incubation of rat C6 glioma cells with 200 nM endothelin-1 (ET-1). Diglycerides 67-70 endothelin 1 Rattus norvegicus 200-204 9644111-3 1998 Total cell DAG rapidly increased by 25-35% from a basal level of 4.5 +/- 0.3 nmol/mg protein during one min of ET-1 treatment and remained constant or slightly decreased between 1 and 2 min. Diglycerides 11-14 endothelin 1 Rattus norvegicus 111-115 9644111-6 1998 Resolution of DAG molecular species by HPLC after incubation of cells with ET-1 revealed that accumulation of DAG species differed in total cell lysate and subcellular compartments. Diglycerides 14-17 endothelin 1 Rattus norvegicus 75-79 9644111-6 1998 Resolution of DAG molecular species by HPLC after incubation of cells with ET-1 revealed that accumulation of DAG species differed in total cell lysate and subcellular compartments. Diglycerides 110-113 endothelin 1 Rattus norvegicus 75-79 9007683-6 1997 ET-1 is known to be an activator of phosphoinositide hydrolysis, resulting in an increased production of IP3 and diacylglycerol (DAG). Diglycerides 129-132 endothelin 1 Rattus norvegicus 0-4 8166295-6 1994 ET-1 also increased cellular diacylglycerol content by approximately 50% within 30 s, which could not be attenuated by pretreatment with nifedipine, suggesting an early activation of protein kinase C that was independent of Ca2+ influx. Diglycerides 29-43 endothelin 1 Rattus norvegicus 0-4 8932513-4 1996 Furthermore, ET-1 caused an increase in the generation of inositol phosphates and diacylglycerol (DAG). Diglycerides 82-96 endothelin 1 Rattus norvegicus 13-17 8932513-4 1996 Furthermore, ET-1 caused an increase in the generation of inositol phosphates and diacylglycerol (DAG). Diglycerides 98-101 endothelin 1 Rattus norvegicus 13-17 1725441-2 1991 In the Rat-1 fibroblastic cell line, ET-1 induces a robust elevation of the intracellular levels of Ca2+, diacylglycerols (DGs), and inositol trisphosphate (IP3). Diglycerides 106-121 endothelin 1 Rattus norvegicus 37-41 8242481-7 1993 The response of 1,2-diacylglycerol to ET-1 was blunted in aorta of SHR, whereas no significant differences in diacylglycerol accumulation could be found in mesenteric vessels between SHR and WKY. Diglycerides 20-34 endothelin 1 Rattus norvegicus 38-42 8242481-9 1993 We conclude that in the aorta of 18-week-old SHR there is reduced generation of second messengers (inositol phosphates and diacylglycerol), which underlies its decreased response to ET-1. Diglycerides 123-137 endothelin 1 Rattus norvegicus 182-186 1725441-2 1991 In the Rat-1 fibroblastic cell line, ET-1 induces a robust elevation of the intracellular levels of Ca2+, diacylglycerols (DGs), and inositol trisphosphate (IP3). Diglycerides 123-126 endothelin 1 Rattus norvegicus 37-41 2173712-7 1990 In addition, endothelin-1 stimulates phosphoinositide hydrolysis and the accumulation of diacylglycerol. Diglycerides 89-103 endothelin 1 Rattus norvegicus 13-25 24726828-13 2015 Similarly, whereas the PKC inhibitor chelerythrine (10 muM) attenuated ET-1-induced contraction in vena cava and aorta (5% +- 2% and 50% +- 5% of control, respectively; P < .05), only the vena cava contracted to the DAG analogue 1-oleoyl-2-acetyl-sn-glycerol. Diglycerides 219-222 endothelin 1 Rattus norvegicus 71-75 24726828-15 2015 Rather, DAG:not IP3:may contribute to contraction to ET-1 in vena cava, in part by activation of PKC. Diglycerides 8-11 endothelin 1 Rattus norvegicus 53-57