PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9855067-1 1998 OBJECTIVE: The effect of blockade of the enzyme ornithine decarboxylase by difluoromethylornithine (DFMO) on hepatocellular necrosis and survival in rats treated with thioacetamide (TAA) was investigated. Thioacetamide 167-180 ornithine decarboxylase 1 Rattus norvegicus 48-71 2713421-1 1989 A protein inhibiting a protein inhibitor (antizyme) to ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) (ODC), antizyme inhibitor, was purified from the liver cytosol of thioacetamide-treated rats by procedures including antizyme affinity chromatography. Thioacetamide 186-199 ornithine decarboxylase 1 Rattus norvegicus 55-78 8681450-3 1996 Thioacetamide (TAA) administration caused a single peak of ODC activity 20 h after treatment, while there had been the maximum increases of the three ODC-mRNAs 4-h earlier. Thioacetamide 0-13 ornithine decarboxylase 1 Rattus norvegicus 59-62 3621358-1 1987 We have studied the activity, thiol-dependency and Km of ornithine decarboxylase (ODC) from the following sources: liver of rats subjected to partial hepatectomy or administered thioacetamide, the rat 3924A Morris hepatoma, the rat AH130 Yoshida ascites hepatoma, a mouse transplantable mammary carcinoma and kidney of rats administered testosterone propionate. Thioacetamide 178-191 ornithine decarboxylase 1 Rattus norvegicus 82-85 2605669-2 1989 Such a treatment with Co2+ ion induced ODC level to a 10-fold greater extent than single dose of the metal ion or well-known inducers of the enzyme, such as thioacetamide or carbon tetrachloride. Thioacetamide 157-170 ornithine decarboxylase 1 Rattus norvegicus 39-42 3282545-7 1988 N-Methyl-, N-ethyl-, N-propyl- and N-butylputrescines (50 mumol per 100 g body weight) were assayed as inhibitors of thioacetamide-induced rat liver ornithine decarboxylase. Thioacetamide 117-130 ornithine decarboxylase 1 Rattus norvegicus 149-172 3282545-9 1988 Both putrescine and N-methylputrescine were found to stabilize the thioacetamide-induced ornithine decarboxylase at the onset of the enzyme"s degradation, while 2-alkylputrescines were inhibitory under similar conditions. Thioacetamide 67-80 ornithine decarboxylase 1 Rattus norvegicus 89-112 3595616-1 1987 Partially purified ornithine decarboxylase, isolated from the liver of thioacetamide-treated rats, is stable in the absence of added low-molecular-mass thiols or other reducing agents. Thioacetamide 71-84 ornithine decarboxylase 1 Rattus norvegicus 19-42 3527275-10 1986 N-Methyl, 1-methyl and 2-methylputrescines were found to inhibit in vivo the activity of rat liver ornithine decarboxylase which had been previously induced by thioacetamide treatment. Thioacetamide 160-173 ornithine decarboxylase 1 Rattus norvegicus 99-122 2874812-10 1986 Thioacetamide increased the activity of hepatic ornithine decarboxylase by about 40-fold, but the Rh(III) complex did not reverse this effect. Thioacetamide 0-13 ornithine decarboxylase 1 Rattus norvegicus 48-71 6699738-0 1984 The effect of a low protein diet on the response of rat colonic and hepatic ornithine decarboxylase activity to sodium deoxycholate and thioacetamide treatment. Thioacetamide 136-149 ornithine decarboxylase 1 Rattus norvegicus 76-99 3083692-1 1986 In virgin female rats thioacetamide administration (1 mg/100 g body wt) induced a 16-fold increase in liver ornithine decarboxylase (ODC) activity and a significant decrease (19%) in hepatic urea concentration. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 108-131 3083692-1 1986 In virgin female rats thioacetamide administration (1 mg/100 g body wt) induced a 16-fold increase in liver ornithine decarboxylase (ODC) activity and a significant decrease (19%) in hepatic urea concentration. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 133-136 4072800-1 1985 A single injection of thioacetamide into starved rats induced a 40- to 100-fold increase in hepatic ODC activity. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 100-103 6479171-4 1984 A single injection of thioacetamide was found to cause several fold increases in both immunotitratable ODC protein and polysomal ODC-mRNA activity, while it provoked a much larger increase in ODC activity in rat liver. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 103-106 6479171-4 1984 A single injection of thioacetamide was found to cause several fold increases in both immunotitratable ODC protein and polysomal ODC-mRNA activity, while it provoked a much larger increase in ODC activity in rat liver. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 129-132 6479171-4 1984 A single injection of thioacetamide was found to cause several fold increases in both immunotitratable ODC protein and polysomal ODC-mRNA activity, while it provoked a much larger increase in ODC activity in rat liver. Thioacetamide 22-35 ornithine decarboxylase 1 Rattus norvegicus 129-132 6479171-5 1984 The results indicate that the induction of hepatic ODC activity by thioacetamide treatment is due not only to an increase in the activity of polysomal ODC-mRNA but also to a translational and/or posttranslational control. Thioacetamide 67-80 ornithine decarboxylase 1 Rattus norvegicus 51-54 6479171-5 1984 The results indicate that the induction of hepatic ODC activity by thioacetamide treatment is due not only to an increase in the activity of polysomal ODC-mRNA but also to a translational and/or posttranslational control. Thioacetamide 67-80 ornithine decarboxylase 1 Rattus norvegicus 151-154 3994674-5 1985 Only one form of ornithine decarboxylase was found in thioacetamide-treated rat liver and Morris hepatoma 7777. Thioacetamide 54-67 ornithine decarboxylase 1 Rattus norvegicus 17-40 6667263-0 1983 Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver. Thioacetamide 74-87 ornithine decarboxylase 1 Rattus norvegicus 32-55 6652876-5 1983 The hepatic ornithine decarboxylase antizyme in thioacetamide-treated rats was minimal at 40 and 80 h after carcinogen administration. Thioacetamide 48-61 ornithine decarboxylase 1 Rattus norvegicus 12-35 6652876-7 1983 This time is much longer than that required to restore normal ornithine decarboxylase activity in liver of thioacetamide-treated rats. Thioacetamide 107-120 ornithine decarboxylase 1 Rattus norvegicus 62-85 6816220-4 1982 Treatment of rats with thioacetamide or carbon tetrachloride or by partial hepatectomy produced substantial increases in ornithine decarboxylase activity and parallel increases in the amount of enzyme protein as determined by the extent of binding of difluoromethyl[5-(14)C]ornithine. Thioacetamide 23-36 ornithine decarboxylase 1 Rattus norvegicus 121-144 6848497-1 1983 Ornithine decarboxylase was purified to homogeneity, as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and polyacrylamide gel electrofocusing, about 710,000-fold with a 35% yield from the liver cytosol of thioacetamide-treated rats. Thioacetamide 226-239 ornithine decarboxylase 1 Rattus norvegicus 0-23 7341240-2 1981 Ornithine decarboxylase was purified approximately 37000-fold with a 15% yield from livers of rats pretreated with thioacetamide. Thioacetamide 115-128 ornithine decarboxylase 1 Rattus norvegicus 0-23 6809059-1 1982 Ornithine decarboxylase (EC 4.1.1.17) was purified to near homogeneity from the livers of thioacetamide- and DL-alpha-hydrazino-delta aminovaleric acid-treated rats by using three types of affinity chromatography with pyridoxamine phosphate-Sepharose, pyridoxamine phosphate-dipropylenetriamine-Sepharose and heparin-Sepharose. Thioacetamide 90-103 ornithine decarboxylase 1 Rattus norvegicus 0-23 646807-2 1978 This effect was seen in control rats and in rats in which hepatic ornithine decarboxylase activity had been increased by administration of growth hormone (somatotropin) or thioacetamide. Thioacetamide 172-185 ornithine decarboxylase 1 Rattus norvegicus 66-89 16004-1 1977 Rat liver ornithine decarboxylase induced by injection of thioacetamide has been separated into at least two fractions by covalent chromatography on an activated thiol-Sepharose 4B column. Thioacetamide 58-71 ornithine decarboxylase 1 Rattus norvegicus 10-33 16005-1 1977 Two forms of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) were purified from the livers of rats which had been treated with thioacetamide for 16 h (for details, see miniprint to Obenrader, M.F., and Prouty, W. F. (1977) J. Biol. Thioacetamide 144-157 ornithine decarboxylase 1 Rattus norvegicus 13-36 16005-15 1977 The antibody preparation has been used in a titration method to assess the half-life of antigen in livers of rats induced for ornithine decarboxylase by injection of thioacetamide. Thioacetamide 166-179 ornithine decarboxylase 1 Rattus norvegicus 126-149 6788836-6 1981 Both labeled inhibitor molecules were successfully localized cytochemically within specific cells of the developing rat cerebellum and rat liver following thioacetamide injection where ODC activity is greatly enhanced. Thioacetamide 155-168 ornithine decarboxylase 1 Rattus norvegicus 185-188 5073764-0 1972 Studies on ornithine decarboxylase from the liver of thioacetamide-treated rats. Thioacetamide 53-66 ornithine decarboxylase 1 Rattus norvegicus 11-34