PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10903342-5 2000 Surprisingly, reduction of EPOR expression using antisense oligodeoxynucleotides suppressed erythropoiesis stimulated not only by SCF and EPO, but also by SCF, sIL-6R, and IL-6. Oligodeoxyribonucleotides 59-80 interleukin 6 Homo sapiens 161-165 15534490-1 2004 Subcutaneous injection of normal human volunteers with a B-class CpG oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH1-like pattern of systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-alpha, and IFN-inducible chemokines. Oligodeoxyribonucleotides 69-89 interleukin 6 Homo sapiens 212-216 15534490-1 2004 Subcutaneous injection of normal human volunteers with a B-class CpG oligodeoxynucleotide (ODN) TLR9 agonist, CPG 7909, induced a TH1-like pattern of systemic innate immune activation manifested by expression of IL-6, IL-12p40, IFN-alpha, and IFN-inducible chemokines. Oligodeoxyribonucleotides 91-94 interleukin 6 Homo sapiens 212-216 15240713-7 2004 Stimulation of the above-mentioned cells with bacterial DNA or CpG oligodeoxynucleotide resulted in an inflammatory reaction characterized by a dose-dependent up-regulation of cytokines (IL-6, IL-8) and human beta-defensin 2. Oligodeoxyribonucleotides 67-87 interleukin 6 Homo sapiens 187-191 14551144-9 2004 We show that in mature PDCs adenosine reduces interleukin-6 (IL-6), IL-12, and IFN-alpha production in response to CpG oligodeoxynucleotides (ODN). Oligodeoxyribonucleotides 119-140 interleukin 6 Homo sapiens 61-65 17023687-6 2007 Plasmacytoid-DC responded to the CpG oligodeoxynucleotide, CpG 2216, by production of the proinflammatory cytokines, IFN-alpha and IL-6. Oligodeoxyribonucleotides 37-57 interleukin 6 Homo sapiens 131-135 12901869-6 2003 Two NF-kappaB inhibitors, pyrrolidine dithiocarbamanate (PDTC) and SN50, or antisense oligodeoxynucleotides for NF-kappaB p65 and p50 suppressed IL-6 mRNA expressions induced by continuous stretch. Oligodeoxyribonucleotides 86-107 interleukin 6 Homo sapiens 145-149 11877294-3 2002 Furthermore, the IL-6-induced proliferation of CD45+ U266 myeloma cells was significantly suppressed by Lyn-specific antisense oligodeoxynucleotides or a selective src kinase inhibitor. Oligodeoxyribonucleotides 127-148 interleukin 6 Homo sapiens 17-21 18636446-5 1997 Antisense oligodeoxynucleotides complementary to the mRNA encoding gp 130 inhibited the upregulation of haptoglobin by IL-6-stimulated HepG2 cells by about 50%. Oligodeoxyribonucleotides 10-31 interleukin 6 Homo sapiens 119-123 9921985-7 1999 Both IL-6- and OM-mediated effects are inhibited by the treatment of PC-3 with an antisense oligodeoxynucleotide against gp130, the protein kinase inhibitor genistein (GNS), or the monoterpene perillic acid (PA), a posttranslational inhibitor of p21ras isoprenylation. Oligodeoxyribonucleotides 92-112 interleukin 6 Homo sapiens 5-9 10826501-7 2000 A decoy oligodeoxynucleotide bearing the NF-kappaB binding site inhibited ET-1-stimulated IL-6 release to a great extent suggesting that this transcription factor plays a key role for cytokine production elicited by ET-1. Oligodeoxyribonucleotides 8-28 interleukin 6 Homo sapiens 90-94 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Oligodeoxyribonucleotides 18-39 interleukin 6 Homo sapiens 94-98 10505115-7 1999 Likewise, the CpG oligodeoxynucleotides 1760 (phosphorothioate) and 2059 (unmodified) induced IL-6 synthesis, but the corresponding control oligonucleotides 1908 and 2077 did not CpG DNA and LPS enhanced IL-6 synthesis synergistically. Oligodeoxyribonucleotides 18-39 interleukin 6 Homo sapiens 204-208 7919342-6 1994 c-Jun antisense, but not sense, oligodeoxynucleotide (ODN) significantly decreases PWM-related B-cell (1) proliferation; (2) IL-6 mRNA induction; (3) IL-6 secretion; and (4) nuclear extract binding to AP-1 in electrophoretic mobility shift assay. Oligodeoxyribonucleotides 54-57 interleukin 6 Homo sapiens 125-129 7706747-0 1995 Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells. Oligodeoxyribonucleotides 34-54 interleukin 6 Homo sapiens 10-14 7622611-7 1995 Megakaryocytic colony (CFU-Meg) formation from A-T-PMCs in the presence of interleukin-6 (IL-6) + IL-3 + Epo was also increased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 144-164 interleukin 6 Homo sapiens 75-88 7622611-7 1995 Megakaryocytic colony (CFU-Meg) formation from A-T-PMCs in the presence of interleukin-6 (IL-6) + IL-3 + Epo was also increased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 144-164 interleukin 6 Homo sapiens 90-94 8482564-4 1993 Exposure of ovarian cancer cell lines (CAOV-3, OVCAR-3, and OC-436), to 1-5 microM of a 15-base single-stranded antisense IL-6 oligodeoxynucleotide, specific for a sequence in the second coding exon of the IL-6 gene, resulted in decreased IL-6 production and a > 80-85% inhibition of cellular proliferation. Oligodeoxyribonucleotides 127-147 interleukin 6 Homo sapiens 122-126 1371302-4 1992 Megakaryocytic colony (CFU-Meg) formation from A-T-MNC or CD34+ cells in the presence of IL-6 + IL-3 + erythropoietin (Epo) was also markedly decreased after antisense oligodeoxynucleotide treatment. Oligodeoxyribonucleotides 168-188 interleukin 6 Homo sapiens 89-100 1864979-6 1991 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Oligodeoxyribonucleotides 121-142 interleukin 6 Homo sapiens 90-94 1806185-3 1991 For instance, we showed that oligodeoxynucleotides antisens of IL6 mRNA were capable to decrease the proliferation of two different myeloma cell lines. Oligodeoxyribonucleotides 29-50 interleukin 6 Homo sapiens 63-66 1818294-3 1991 For instance, we showed that oligodeoxynucleotides antisens of IL6 mRNA were capable to decrease the proliferation of two different myeloma cell lines. Oligodeoxyribonucleotides 29-50 interleukin 6 Homo sapiens 63-66 33878273-7 2021 We also show that soft AIE dots loaded with cytosine-phosphate-guanine (CpG) oligodeoxynucleotides can induce strong immunostimulatory effects, producing a high level of various proinflammatory cytokines including tumor necrosis factor (TNF)-R, interleukin (IL)-6, and IL-12. Oligodeoxyribonucleotides 77-98 interleukin 6 Homo sapiens 245-263 23674892-10 2013 CpG oligodeoxynucleotides loaded onto BNNS-CS complexes significantly enhanced production of interleukin-6 and tumor necrosis factor-alpha by peripheral blood mononuclear cells compared with CpG oligodeoxynucleotides directly loaded onto BNNS, or when Lipofectamine 2000 was used as the carrier. Oligodeoxyribonucleotides 4-25 interleukin 6 Homo sapiens 93-138 19384869-5 2009 Stimulation of BM CD20(+) B cells by CpG-containing oligodeoxynucleotide-enhanced expression of activation markers (CD86 and CD54) triggered IL-6 and TNF-alpha secretion and cell proliferation. Oligodeoxyribonucleotides 52-72 interleukin 6 Homo sapiens 141-145 18546154-6 2008 DCIP-selective antisense oligodeoxynucleotide inhibited the expression of TNF-alpha-responsive gene targets including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, IL-6, IL-8, IP-10, and thymic stromal lymphopoietin. Oligodeoxyribonucleotides 25-45 interleukin 6 Homo sapiens 188-192 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 20-40 interleukin 6 Homo sapiens 132-145 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 20-40 interleukin 6 Homo sapiens 147-151 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 42-45 interleukin 6 Homo sapiens 132-145 23706224-1 2013 Chitosan-silica/CpG oligodeoxynucleotide (ODN) nanohybrids were synthesized to stimulate Toll-like receptor 9-mediated induction of interleukin-6 (IL-6). Oligodeoxyribonucleotides 42-45 interleukin 6 Homo sapiens 147-151 20605877-7 2010 However, this enhanced potency was selective for TLR9-induced B-cell cycling and apoptosis protection while TLR9-induced IL-6, an event that strongly depends on signaling via late endosomes, still required 10 times more Class R oligodeoxynucleotides. Oligodeoxyribonucleotides 228-249 interleukin 6 Homo sapiens 121-125