PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31461951-1 2019 We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. ethylene dichloride 117-135 matrix metallopeptidase 9 Mus musculus 42-68 31461951-7 2019 Furthermore, pretreatment with an inhibitor against MMP-9 obstructs the decrease of TJs in the brain of 1,2-DCE-intoxicated mice. ethylene dichloride 104-111 matrix metallopeptidase 9 Mus musculus 52-57 31461951-1 2019 We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. ethylene dichloride 117-135 matrix metallopeptidase 9 Mus musculus 70-75 31461951-1 2019 We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. ethylene dichloride 137-144 matrix metallopeptidase 9 Mus musculus 42-68 31461951-1 2019 We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. ethylene dichloride 137-144 matrix metallopeptidase 9 Mus musculus 70-75 31461951-2 2019 We also found that the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway resulted in MMP-9 overexpression and nuclear factor-kappaB (NF-kappaB) activation in mice treated with 1,2-DCE. ethylene dichloride 192-199 matrix metallopeptidase 9 Mus musculus 101-106 31461951-3 2019 In this study, we further hypothesized that inflammatory reactions mediated by the p38 MAPK/ NF-kappaB signaling pathway might be involved in MMP-9 overexpression, blood-brain barrier (BBB) disruption and edema formation in the brain of 1,2-DCE-intoxicated mice. ethylene dichloride 237-244 matrix metallopeptidase 9 Mus musculus 142-147 30081051-0 2018 Involvement of the p38 MAPK signaling pathway in overexpression of matrix metalloproteinase-9 during the course of brain edema in 1,2-dichloroethane-intoxicated mice. ethylene dichloride 130-148 matrix metallopeptidase 9 Mus musculus 67-93 30081051-3 2018 In the present study, we hypothesized that the p38 MAPK (p38) signaling pathway could be activated in 1,2-DCE-intoxicated mice, which in turn stimulates transcription factors, such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and then enhances the expression of proinflammatory factors, including matrix metalloproteinase-9 (MMP-9), finally leading to blood-brain barrier (BBB) disruption and brain edema formation. ethylene dichloride 102-109 matrix metallopeptidase 9 Mus musculus 321-347 30081051-3 2018 In the present study, we hypothesized that the p38 MAPK (p38) signaling pathway could be activated in 1,2-DCE-intoxicated mice, which in turn stimulates transcription factors, such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and then enhances the expression of proinflammatory factors, including matrix metalloproteinase-9 (MMP-9), finally leading to blood-brain barrier (BBB) disruption and brain edema formation. ethylene dichloride 102-109 matrix metallopeptidase 9 Mus musculus 349-354 34685627-4 2021 Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice. ethylene dichloride 259-266 matrix metallopeptidase 9 Mus musculus 212-217 30087244-3 2018 In our previous studies, we found that matrix metalloproteinases-9 (MMP-9) expression was enhanced in mouse brains upon treatment with 1,2-DCE, and in rat astrocytes exposed to 2-CE. ethylene dichloride 135-142 matrix metallopeptidase 9 Mus musculus 39-66 30087244-3 2018 In our previous studies, we found that matrix metalloproteinases-9 (MMP-9) expression was enhanced in mouse brains upon treatment with 1,2-DCE, and in rat astrocytes exposed to 2-CE. ethylene dichloride 135-142 matrix metallopeptidase 9 Mus musculus 68-73 24964198-10 2014 Our results suggested that exposure to 1,2-DCE might up-regulate the expression of AQP4 protein and MMP9 mRNA at the early phase of brain edema, and AQP4 may play an important role in the brain edema formation. ethylene dichloride 39-46 matrix metallopeptidase 9 Mus musculus 100-104