PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15292961-3 2004 In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite. arsenite 226-234 mitogen-activated protein kinase 14 Homo sapiens 103-106 18715270-4 2009 Furthermore, melatonin inhibited arsenite-induced phosphorylation of p38 and DNA fragmentation. arsenite 33-41 mitogen-activated protein kinase 14 Homo sapiens 69-72 17373649-0 2007 Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. arsenite 87-95 mitogen-activated protein kinase 14 Homo sapiens 26-29 17373649-9 2007 Under arsenite, inhibition of p38 activation or depletion of p38alpha suppressed cyclin B1 ubiquitination and proteolysis, while forced expression of MKK6-p38 accelerated these events. arsenite 6-14 mitogen-activated protein kinase 14 Homo sapiens 30-33 17373649-10 2007 Inactivation of p38 in arsenite-treated early G(2) cells allowed G(2)-to-M progression, blocked apoptosis, increased cell viability, and decreased micronucleus formation. arsenite 23-31 mitogen-activated protein kinase 14 Homo sapiens 16-19 17373649-11 2007 Thus, p38 signaling pathway triggering cyclin B1 proteolysis after arsenite may play an important role in connecting G(2) arrest with apoptosis or genome instability. arsenite 67-75 mitogen-activated protein kinase 14 Homo sapiens 6-9 17196236-7 2007 In contrast, addition of a superoxide scavenger or inhibition of p38 activity decreased the arsenite-dependent response by 80-90% suggesting that ROS and p38 are required for HO-1 induction. arsenite 92-100 mitogen-activated protein kinase 14 Homo sapiens 65-68 17196236-7 2007 In contrast, addition of a superoxide scavenger or inhibition of p38 activity decreased the arsenite-dependent response by 80-90% suggesting that ROS and p38 are required for HO-1 induction. arsenite 92-100 mitogen-activated protein kinase 14 Homo sapiens 154-157 16114012-5 2006 When cells were pre-treated with SB 203580, which inhibits HSP27 phosphorylation through inhibition of p38 MAP kinase activation, the arsenite-induced reduction of UVB-induced apoptosis was partially reversed. arsenite 134-142 mitogen-activated protein kinase 14 Homo sapiens 103-106 15504454-3 2004 In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line. arsenite 133-141 mitogen-activated protein kinase 14 Homo sapiens 126-129 15504454-4 2004 Arsenite concentrations > or =100 microM stimulate rapid activation of p38 and ERK MAP kinases. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 74-77 15504454-5 2004 However, upon extended exposure (24 h), persistent stimulation of p38 and ERK MAP kinases was detected at low micromolar concentrations of arsenite. arsenite 139-147 mitogen-activated protein kinase 14 Homo sapiens 66-69 15327774-5 2004 Arsenite, but not heat shock, requires signaling via p38 MAP kinase for Hsp70 induction and histone H3 phosphorylation. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 53-56 15037631-6 2004 p38 activation by both adenovirus-mediated gene delivery of constitutively active p38 activator MKK6 and by arsenite selectively induces cell death in K-ras-activated human colon cancer HCT116 cells but not in the K-ras-disrupted HCT116-derived sublines. arsenite 108-116 mitogen-activated protein kinase 14 Homo sapiens 0-3 15056798-6 2004 Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis. arsenite 193-201 mitogen-activated protein kinase 14 Homo sapiens 66-69 15056798-6 2004 Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis. arsenite 313-321 mitogen-activated protein kinase 14 Homo sapiens 66-69 14511371-0 2003 Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 97-100 14511371-8 2003 Both arsenite and insulin-induced glucose uptake were inhibited partially by the p38 MAP kinase inhibitor, SB203580. arsenite 5-13 mitogen-activated protein kinase 14 Homo sapiens 81-84 14511371-12 2003 This response to arsenite is not functionally linked to early steps of the IR-IRS-PI-3" kinase pathway, but does coincide with c-Cbl phosphorylation, basal levels of PKC-lambda activity and p38 MAPK activation. arsenite 17-25 mitogen-activated protein kinase 14 Homo sapiens 190-193 12839928-3 2003 Our results show that activation of p38 by adenoviral expression of MKK3b or arsenite treatment was followed by rapid dephosphorylation of MEK1,2 and subsequent apoptosis in human skin fibroblasts. arsenite 77-85 mitogen-activated protein kinase 14 Homo sapiens 36-39 12781867-4 2003 These data show that while the arsenite-induced increase in the phosphorylation of eIF4E and hsp25 was sensitive to SB203580 in cells expressing WT-SAPK2a, these responses to SB203580 were abrogated in cells expressing DR-SAPK2a. arsenite 31-39 mitogen-activated protein kinase 14 Homo sapiens 148-154 12475989-4 2003 We report opposite effects of the p38 isoforms on regulation of AP-1-dependent activities by p38 activators MAPK kinase 6 (MKK6) and/or arsenite in human breast cancer cells. arsenite 136-144 mitogen-activated protein kinase 14 Homo sapiens 34-37 11689710-5 2001 The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes. arsenite 108-116 mitogen-activated protein kinase 14 Homo sapiens 152-155 11983707-6 2002 The essential role of the p38 and JNK stress pathways in up-regulation of VDR expression is further confirmed by using the chemical stimulator arsenite. arsenite 143-151 mitogen-activated protein kinase 14 Homo sapiens 26-29 11689710-5 2001 The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes. arsenite 108-116 mitogen-activated protein kinase 14 Homo sapiens 207-210 11788791-13 2001 Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite-induced phosphorylation of AKT and eNOS. arsenite 78-86 mitogen-activated protein kinase 14 Homo sapiens 42-45 11788791-0 2001 Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 69-72 11788791-11 2001 Arsenite also induced phosphorylation of p38. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 41-44 11788791-15 2001 CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes. arsenite 50-58 mitogen-activated protein kinase 14 Homo sapiens 115-118 9545260-5 1998 Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580. arsenite 22-30 mitogen-activated protein kinase 14 Homo sapiens 196-199 10964950-0 2000 Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 100-103 10964950-9 2000 Expression of dominant-interfering mutants of the JNK or p38 pathways inhibited apoptosis induced by arsenite, whereas expression of constitutive active mutants for either pathway induced apoptosis. arsenite 101-109 mitogen-activated protein kinase 14 Homo sapiens 57-60 10964950-11 2000 These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway. arsenite 56-64 mitogen-activated protein kinase 14 Homo sapiens 38-41 10983896-6 2000 Arsenite-induced phosphorylation of Erks was inhibited by rottlerin, while safingol inhibited arsenite-induced phosphorylation of JNKs and p38 kinases. arsenite 94-102 mitogen-activated protein kinase 14 Homo sapiens 139-142 10983896-8 2000 These data demonstrate that PKCdelta, PKCepsilon, and PKCalpha mediate arsenite-induced AP-1 activation in JB6 cells through different MAP kinase (Erks, JNKs, and p38 kinases) pathways. arsenite 71-79 mitogen-activated protein kinase 14 Homo sapiens 163-166 11055208-13 2000 The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38. arsenite 32-40 mitogen-activated protein kinase 14 Homo sapiens 198-201 11055208-14 2000 Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents. arsenite 34-42 mitogen-activated protein kinase 14 Homo sapiens 20-23 10747897-2 2000 Here we demonstrate that the stress signaling agents anisomycin, arsenite, and tumor necrosis factor-alpha stimulate the specific enzyme activity of CK2 in the human cervical carcinoma HeLa cells by up to 8-fold, and this could be blocked by the p38 MAP kinase inhibitor SB203580. arsenite 65-73 mitogen-activated protein kinase 14 Homo sapiens 246-249 34861471-10 2022 p38 inhibition markedly increased arsenite-induced Nix protein and reduced p62 protein levels, resulting in increased autophagy and apoptosis. arsenite 34-42 mitogen-activated protein kinase 14 Homo sapiens 0-3 34861471-0 2022 Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 46-49 9139689-4 1997 Arsenite or osmotic stress potently activated p38 but were ineffective in inducing NF-kappaB activation. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 46-49 23376440-7 2013 Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells. arsenite 0-8 mitogen-activated protein kinase 14 Homo sapiens 65-68 23376440-8 2013 Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. arsenite 34-42 mitogen-activated protein kinase 14 Homo sapiens 80-83 23152511-7 2013 The sequestration of p38-P and OGT in IBs appeared to be reversible: oxidative stress resulting from arsenite treatment transformed large IBs into a scattering of smaller bodies, suggestive of partial disassembly, and this was associated with MK2 phosphorylation and OGN addition. arsenite 101-109 mitogen-activated protein kinase 14 Homo sapiens 21-24 22492492-8 2012 The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) . arsenite 20-28 mitogen-activated protein kinase 14 Homo sapiens 46-49 32315827-8 2020 Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 muM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38. arsenite 73-81 mitogen-activated protein kinase 14 Homo sapiens 300-303 24865968-5 2014 HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs. arsenite 63-71 mitogen-activated protein kinase 14 Homo sapiens 22-25