PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24499675-0 2014 Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells. arsenite 0-8 tumor protein p53 Homo sapiens 42-45 24499675-1 2014 In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). arsenite 38-46 tumor protein p53 Homo sapiens 75-78 24499675-5 2014 This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. arsenite 19-27 tumor protein p53 Homo sapiens 122-125 24499675-7 2014 Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage. arsenite 16-24 tumor protein p53 Homo sapiens 62-65 24499675-7 2014 Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage. arsenite 16-24 tumor protein p53 Homo sapiens 103-106 23396362-3 2014 We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50). arsenite 52-60 tumor protein p53 Homo sapiens 69-72 22706169-0 2012 Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes. arsenite 8-16 tumor protein p53 Homo sapiens 40-43 22706169-3 2012 Our present study shows that, for human keratinocytes (HaCaT) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (ERKs), which leads to up-regulation of nuclear factor kappaB (NF-kappaB) binding to DNA and to elevated, NF-kappaB-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis). arsenite 92-100 tumor protein p53 Homo sapiens 299-302 22706169-9 2012 By identifying a mechanism whereby ERKs and JNKs-mediated regulation of the p53-survivin signal pathway is involved in the biphasic effects of arsenite on human keratinocytes, our data expand understanding of arsenite-induced cell proliferation, neoplastic transformation, DNA damage, and apoptosis. arsenite 143-151 tumor protein p53 Homo sapiens 76-79 22706169-9 2012 By identifying a mechanism whereby ERKs and JNKs-mediated regulation of the p53-survivin signal pathway is involved in the biphasic effects of arsenite on human keratinocytes, our data expand understanding of arsenite-induced cell proliferation, neoplastic transformation, DNA damage, and apoptosis. arsenite 209-217 tumor protein p53 Homo sapiens 76-79 22447124-0 2012 Blockade of p53 by HIF-2alpha, but not HIF-1alpha, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. arsenite 66-74 tumor protein p53 Homo sapiens 12-15 22447124-12 2012 Thus, our studies show that blockade of p53 function by inhibiting the ubiquitin-mediated proteasome degradation of HIF-2alpha, but not that of HIF-1alpha, is involved in arsenite-induced proliferation and neoplastic transformation of HBE cells. arsenite 171-179 tumor protein p53 Homo sapiens 40-43 22366412-0 2012 DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells. arsenite 62-70 tumor protein p53 Homo sapiens 35-38 22366412-6 2012 Knockdown of DNA-PKcs/JNK2 signal pathway or p53 reduces apoptosis but elevates the DNA damage induced by a high level of arsenite. arsenite 122-130 tumor protein p53 Homo sapiens 45-48 22366412-7 2012 These results suggest that DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis. arsenite 89-97 tumor protein p53 Homo sapiens 62-65 22551203-11 2012 Short-term in vitro arsenite treatment in lymphoblastoid cells clearly demonstrated a significant global hypomethylation, determined as reduction in LINE-1 methylation and total 5-MedC content, and p53 hypermethylation (p < 0.05). arsenite 20-28 tumor protein p53 Homo sapiens 198-201 22260869-0 2012 Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. arsenite 0-8 tumor protein p53 Homo sapiens 65-68 22260869-1 2012 Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels. arsenite 0-8 tumor protein p53 Homo sapiens 175-178 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 113-121 tumor protein p53 Homo sapiens 36-39 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 113-121 tumor protein p53 Homo sapiens 41-44 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 113-121 tumor protein p53 Homo sapiens 41-44 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 239-247 tumor protein p53 Homo sapiens 36-39 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 239-247 tumor protein p53 Homo sapiens 41-44 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 239-247 tumor protein p53 Homo sapiens 41-44 22260869-5 2012 Transcriptional upregulation of a chromatin-embedded p53-responsive reporter gene in either arsenite or nutlin-3 stimulated neuroblastoma cells revealed that the transcriptional activity of p53 was increased under these conditions. arsenite 92-100 tumor protein p53 Homo sapiens 53-56 22260869-5 2012 Transcriptional upregulation of a chromatin-embedded p53-responsive reporter gene in either arsenite or nutlin-3 stimulated neuroblastoma cells revealed that the transcriptional activity of p53 was increased under these conditions. arsenite 92-100 tumor protein p53 Homo sapiens 190-193 22260869-9 2012 Together, these data show that the upregulation of p53 is causally linked with arsenite-induced cell death in neuroblastoma cells, whereas the upregulation of c-Jun is not part of this apoptotic signaling cascade. arsenite 79-87 tumor protein p53 Homo sapiens 51-54 22130551-4 2012 Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP. arsenite 83-91 tumor protein p53 Homo sapiens 116-119 21292642-4 2011 We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members. arsenite 132-140 tumor protein p53 Homo sapiens 49-52 21292642-4 2011 We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members. arsenite 132-140 tumor protein p53 Homo sapiens 100-103 21292642-6 2011 Moreover, stably expressing miR-200b alone in parental nontransformed p53(low)HBECs was sufficient to completely prevent arsenite exposure from inducing EMT and malignant transformation. arsenite 121-129 tumor protein p53 Homo sapiens 70-73 20199942-0 2010 mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells. arsenite 74-82 tumor protein p53 Homo sapiens 55-58 20199942-1 2010 BACKGROUND: Inactivation of p53 is involved in arsenite-induced tumorigenesis; however, the molecular mechanisms remain poorly understood. arsenite 47-55 tumor protein p53 Homo sapiens 28-31 20199942-2 2010 OBJECTIVE: We investigated the molecular mechanisms underlying the inactivation of p53 and neoplastic transformation induced by arsenite in human embryo lung fibroblast (HELF) cells. arsenite 128-136 tumor protein p53 Homo sapiens 83-86 20199942-4 2010 We determined the levels and functions of p53, nuclear factor-kappa B (NF-B; a key transcriptional regulator), and mot-2 (a p53 inhibitor) and their relationships in arsenite-induced transformed HELF cells by two-dimensional electrophoresis, reverse-transcriptase polymerase chain reaction, Western blot, immunofluorescence, and co-immunoprecipitation assays. arsenite 166-174 tumor protein p53 Homo sapiens 42-45 20199942-4 2010 We determined the levels and functions of p53, nuclear factor-kappa B (NF-B; a key transcriptional regulator), and mot-2 (a p53 inhibitor) and their relationships in arsenite-induced transformed HELF cells by two-dimensional electrophoresis, reverse-transcriptase polymerase chain reaction, Western blot, immunofluorescence, and co-immunoprecipitation assays. arsenite 166-174 tumor protein p53 Homo sapiens 124-127 20199942-13 2010 CONCLUSIONS: mot-2-mediated cross talk between NF-B and p53 appears to be involved in arsenite-induced tumorigenesis of HELF cells. arsenite 86-94 tumor protein p53 Homo sapiens 56-59 20375080-0 2010 The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. arsenite 125-133 tumor protein p53 Homo sapiens 38-41 20375080-5 2010 In arsenite-exposed cells, the levels of phospho-p53, p21, and mdm2 increase at early times after exposure. arsenite 3-11 tumor protein p53 Homo sapiens 49-52 20375080-8 2010 Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2. arsenite 191-199 tumor protein p53 Homo sapiens 143-146 20375080-8 2010 Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2. arsenite 191-199 tumor protein p53 Homo sapiens 220-223 20375080-10 2010 Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes. arsenite 137-145 tumor protein p53 Homo sapiens 73-76 20036271-0 2010 Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. arsenite 0-8 tumor protein p53 Homo sapiens 60-63 20036271-6 2010 This laboratory demonstrated earlier that in cells treated with arsenite, the P53-dependent increase in p21(WAF1/CIP1) expression, normally a block to cell cycle progression after DNA damage, is deficient. arsenite 64-72 tumor protein p53 Homo sapiens 78-81 20036271-7 2010 Here we show that although long-term exposure of human keratinocytes (HaCaT) to a nontoxic concentration (0.1 microM) of arsenite decreases the level of global protein poly(ADP-ribosyl)ation, it increases poly(ADP-ribosyl)ation of P53 protein and PARP-1 protein abundance. arsenite 121-129 tumor protein p53 Homo sapiens 231-234 20036271-10 2010 Our results suggest that arsenite"s interference with activation of P53 via poly(ADP-ribosyl)ation may play a role in the comutagenic and cocarcinogenic effects of arsenite. arsenite 25-33 tumor protein p53 Homo sapiens 68-71 20036271-10 2010 Our results suggest that arsenite"s interference with activation of P53 via poly(ADP-ribosyl)ation may play a role in the comutagenic and cocarcinogenic effects of arsenite. arsenite 164-172 tumor protein p53 Homo sapiens 68-71 20000476-0 2010 Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy. arsenite 44-52 tumor protein p53 Homo sapiens 15-18 20000476-7 2010 Although suppression of p53 increased the fraction of arsenite-treated cells with MN, it caused a decrease in the fraction with centromeric DNA. arsenite 54-62 tumor protein p53 Homo sapiens 24-27 19931552-0 2010 Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). arsenite 0-8 tumor protein p53 Homo sapiens 51-54 19931552-7 2010 NNK treatment could also reduce arsenite-induced G2/M cell cycle arrest and apoptosis, these cellular effects were found to be correlated with p53 dysfunction. arsenite 32-40 tumor protein p53 Homo sapiens 143-146 19931552-10 2010 Arsenite would act specifically on this p53 compromised status to induce centrosomal abnormality and colony formation. arsenite 0-8 tumor protein p53 Homo sapiens 40-43 19470404-1 2009 Arsenite effects on the benzo[a]pyrene diol epoxide (BPDE)-DNA adduct-induced mutation were evaluated in three human lung cell-lines--A549 (wild-type p53), WI38-VA13 (p53 inhibited by SV40 large-T antigen), and H1299 (p53-null)--by using the pSP189 shuttle vector, which carries a mutation target supF gene. arsenite 0-8 tumor protein p53 Homo sapiens 167-170 19470404-1 2009 Arsenite effects on the benzo[a]pyrene diol epoxide (BPDE)-DNA adduct-induced mutation were evaluated in three human lung cell-lines--A549 (wild-type p53), WI38-VA13 (p53 inhibited by SV40 large-T antigen), and H1299 (p53-null)--by using the pSP189 shuttle vector, which carries a mutation target supF gene. arsenite 0-8 tumor protein p53 Homo sapiens 167-170 19470404-5 2009 These results suggest that arsenite potentiates the BPDE-induced supF mutation via a p53-independent mechanism. arsenite 27-35 tumor protein p53 Homo sapiens 85-88 19010883-3 2008 Through the mitogen-activated protein kinase pathway, arsenite stimulates the P2 promoter-mediated expression of Hdm2, which then promotes p53 nuclear export. arsenite 54-62 tumor protein p53 Homo sapiens 139-142 17849503-7 2008 Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events. arsenite 10-18 tumor protein p53 Homo sapiens 56-59 18504176-0 2008 [Construction and expression of different mutants of human p53 and their effects on arsenite-induced cell apoptosis]. arsenite 84-92 tumor protein p53 Homo sapiens 59-62 18504176-6 2008 The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells. arsenite 60-68 tumor protein p53 Homo sapiens 23-26 18504176-6 2008 The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells. arsenite 149-157 tumor protein p53 Homo sapiens 91-94 18504176-6 2008 The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells. arsenite 149-157 tumor protein p53 Homo sapiens 91-94 18504176-7 2008 CONCLUSION: The phosphorylation on Ser15 of p53 plays an important role in mediating arsenite-induced cell apoptosis. arsenite 85-93 tumor protein p53 Homo sapiens 44-47 18201741-9 2008 Furthermore, arsenite and hyperthermia treatments activated a p53/p21 pathway associated with apoptosis induction, whereas vincristine did not activate this pathway. arsenite 13-21 tumor protein p53 Homo sapiens 62-65 17945324-7 2007 TUNEL analysis confirmed that there was indeed a significantly reduced arsenite-induced apoptosis found in p53-compromised cells. arsenite 71-79 tumor protein p53 Homo sapiens 107-110 17945324-9 2007 In our present study, reduced p21 and Gadd45a expressions and increased centrosomal abnormality (atopic and multiple centrosomes) were observed in both arsenite-treated H1355 and p53-inhibited BEAS-2B cells as compared with similarly treated BEAS-2B cells. arsenite 152-160 tumor protein p53 Homo sapiens 179-182 17906315-8 2007 In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite. arsenite 149-157 tumor protein p53 Homo sapiens 38-41 17906315-8 2007 In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite. arsenite 149-157 tumor protein p53 Homo sapiens 120-123 17906315-11 2007 This study provides us with knowledge of the relationship between p53 and COX-2 over-expression in arsenite-treated urothelial cells and suggests a potential therapeutic role of COX-2 inhibitors in human urothelial malignancies. arsenite 99-107 tumor protein p53 Homo sapiens 66-69 16645841-6 2006 We found that this arsenite-induced G2/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin. arsenite 19-27 tumor protein p53 Homo sapiens 152-155 16645841-8 2006 Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin. arsenite 146-154 tumor protein p53 Homo sapiens 285-288 16966095-0 2006 Exit from arsenite-induced mitotic arrest is p53 dependent. arsenite 10-18 tumor protein p53 Homo sapiens 45-48 16966095-2 2006 Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis. arsenite 148-156 tumor protein p53 Homo sapiens 33-36 16966095-3 2006 OBJECTIVE: Our goal was to examine the role p53 plays in protecting cells from arsenite-induced mitotic arrest. arsenite 79-87 tumor protein p53 Homo sapiens 44-47 16966095-5 2006 RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells. arsenite 50-58 tumor protein p53 Homo sapiens 93-96 16966095-5 2006 RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells. arsenite 50-58 tumor protein p53 Homo sapiens 104-107 16966095-6 2006 Arsenite-treated p53(+) cells exited mitosis normally, whereas p53(-) cells exited mitosis with delayed kinetics. arsenite 0-8 tumor protein p53 Homo sapiens 17-20 16966095-7 2006 Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. arsenite 59-67 tumor protein p53 Homo sapiens 201-204 16966095-7 2006 Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. arsenite 59-67 tumor protein p53 Homo sapiens 212-215 16966095-7 2006 Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. arsenite 133-141 tumor protein p53 Homo sapiens 201-204 16966095-7 2006 Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. arsenite 133-141 tumor protein p53 Homo sapiens 212-215 16966095-9 2006 CONCLUSIONS: p53 promotes mitotic exit and leads to more extensive ID1 induction by arsenite. arsenite 84-92 tumor protein p53 Homo sapiens 13-16 16966095-11 2006 ID1 may play a role in the survival of arsenite-treated p53(+) cells and contribute to arsenic carcinogenicity. arsenite 39-47 tumor protein p53 Homo sapiens 56-59 16614167-0 2006 p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1. arsenite 19-27 tumor protein p53 Homo sapiens 0-3 16614167-3 2006 Arsenite sensitivity correlates with deficient p53 pathways in multiple cell lines. arsenite 0-8 tumor protein p53 Homo sapiens 47-50 16614167-4 2006 The role of p53 in preventing arsenite-induced mitotic arrest-associated apoptosis (MAAA), a form of mitotic catastrophe, was examined in TR9-7 cells, a model cell line with p53 exogenously regulated in a tetracycline-off expression system. arsenite 30-38 tumor protein p53 Homo sapiens 12-15 16614167-6 2006 Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe. arsenite 72-80 tumor protein p53 Homo sapiens 89-92 16614167-9 2006 CDC2-Y15-P was transiently elevated in arsenite-treated p53+ cells but persisted in p53- cells. arsenite 39-47 tumor protein p53 Homo sapiens 56-59 16614167-10 2006 Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells. arsenite 0-8 tumor protein p53 Homo sapiens 17-20 16614167-10 2006 Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells. arsenite 0-8 tumor protein p53 Homo sapiens 52-55 16338954-10 2006 Arsenite raised the levels of phospho-p53 (serine-15) and p53 (DO-1) proteins in both the securin-wild-type and -null cells. arsenite 0-8 tumor protein p53 Homo sapiens 38-41 16338954-10 2006 Arsenite raised the levels of phospho-p53 (serine-15) and p53 (DO-1) proteins in both the securin-wild-type and -null cells. arsenite 0-8 tumor protein p53 Homo sapiens 58-61 16338954-11 2006 The p53-functional cells were more susceptible than the p53-mutational cells to arsenite on the cytotoxicity and apoptosis. arsenite 80-88 tumor protein p53 Homo sapiens 4-7 16338954-11 2006 The p53-functional cells were more susceptible than the p53-mutational cells to arsenite on the cytotoxicity and apoptosis. arsenite 80-88 tumor protein p53 Homo sapiens 56-59 16338954-12 2006 Besides, arsenite decreased the levels of securin proteins to a similar degree in both the p53-functional and -mutational cells. arsenite 9-17 tumor protein p53 Homo sapiens 91-94 16338954-13 2006 Together, it is the first time to demonstrate that the inhibition of securin expression induced by arsenite increases the chromosomal instability and apoptosis via a p53-independent pathway. arsenite 99-107 tumor protein p53 Homo sapiens 166-169 11813266-5 2002 P53, p21, and MDM2 were induced in E6-transfected TK6 cells, as well as in parental TK6 cells after arsenite treatment. arsenite 100-108 tumor protein p53 Homo sapiens 0-3 11813266-7 2002 It indicated that arsenite, but not X-ray, could suppress the transcription of E6 gene and therefore activate the p53 tumor suppressor pathway in TK6-E6 cells. arsenite 18-26 tumor protein p53 Homo sapiens 114-117 11489357-1 2001 In a previous study we reported that methylation within the promoter region of p53 was altered in human lung A549 cells exposed to arsenite over a 2-week period in culture. arsenite 131-139 tumor protein p53 Homo sapiens 79-82 11406180-0 2001 Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite"s comutagenicity. arsenite 112-120 tumor protein p53 Homo sapiens 23-26 11406180-3 2001 To determine whether arsenite affects signaling which might alter DNA repair, this study assesses the effect of arsenite on p53-related signal transduction pathways after ionizing radiation. arsenite 112-120 tumor protein p53 Homo sapiens 124-127 11406180-4 2001 Long-term (14 day) low dose (0.1 microM) arsenite caused a modest increase in p53 expression in WI38 normal human fibroblasts, while only toxic (50 microM) concentrations increased p53 levels after short-term (18 h) exposure. arsenite 41-49 tumor protein p53 Homo sapiens 78-81 11406180-8 2001 These results show that in cells treated with arsenite, p53-dependent increase in p21 expression, normally a block to cell cycle progression after DNA damage, is deficient. arsenite 46-54 tumor protein p53 Homo sapiens 56-59 11406180-10 2001 We suggest that the absence of normal p53 functioning, along with increased positive growth signaling in the presence of DNA damage may result in defective DNA repair and account for the comutagenic effects of arsenite. arsenite 210-218 tumor protein p53 Homo sapiens 38-41 11429707-0 2001 Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha. arsenite 42-50 tumor protein p53 Homo sapiens 59-62 11429707-2 2001 We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely. arsenite 20-28 tumor protein p53 Homo sapiens 65-68 11429707-6 2001 Analysis of GADD45alpha expression in both wild-type and p53-/- fibroblasts indicated that the induction of GADD45alpha by arsenite was independent of the status of p53 protein. arsenite 123-131 tumor protein p53 Homo sapiens 57-60 11103796-0 2000 Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. arsenite 0-8 tumor protein p53 Homo sapiens 17-20 11103796-3 2000 Because p53 plays a guarding role in maintaining genome integrity and accuracy of chromosome segregation, the mechanistic effects of arsenite on p53 activation were analyzed. arsenite 133-141 tumor protein p53 Homo sapiens 145-148 11103796-5 2000 Accompanying the appearance of DNA strand breaks was a significant accumulation of p53 in arsenite-treated HFW cells, as demonstrated by immunoblotting and immunofluorescence techniques. arsenite 90-98 tumor protein p53 Homo sapiens 83-86 11103796-6 2000 p53 downstream proteins, such as p21 and the human homologue of murine double minute-2, were also significantly induced by arsenite treatment. arsenite 123-131 tumor protein p53 Homo sapiens 0-3 11103796-8 2000 Wortmannin, an inhibitor of phosphatidylinositol 3-kinases, inhibited arsenite- or X-ray irradiation-induced p53 accumulation but did not alter UV irradiation- or N-acetyl-Leu-Leu-norleucinal-induced p53 accumulation. arsenite 70-78 tumor protein p53 Homo sapiens 109-112 11103796-9 2000 p53 phosphorylation on serine 15 was also confirmed by immunoblotting technique in arsenite- and X-ray-treated HFW cells but was not observed in UV- or N-acetyl-Leu-Leu-norleucinal-treated HFW cells. arsenite 83-91 tumor protein p53 Homo sapiens 0-3 11103796-10 2000 These results suggest the involvement of a phosphatidylinositol 3-kinase-related protein kinase in arsenite-induced p53 accumulation. arsenite 99-107 tumor protein p53 Homo sapiens 116-119 11103796-13 2000 Together, these findings infer that arsenite-induced DNA strand breaks may lead to p53 phosphorylation and accumulation through an ataxia telangiectasia mutated-dependent pathway in HFW cells. arsenite 36-44 tumor protein p53 Homo sapiens 83-86 10491313-4 1999 Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner. arsenite 0-8 tumor protein p53 Homo sapiens 17-20 10491313-4 1999 Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner. arsenite 0-8 tumor protein p53 Homo sapiens 63-66 34425169-9 2021 A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function. arsenite 54-62 tumor protein p53 Homo sapiens 195-198 33097607-6 2020 Therefore, taken together with the previous report, we conclude that both IKKalpha- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy targeting feedback degradation of IKKalpha in arsenite-induced proapoptotic responses. arsenite 229-237 tumor protein p53 Homo sapiens 103-106 32315827-8 2020 Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 muM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38. arsenite 73-81 tumor protein p53 Homo sapiens 284-287 32373892-0 2020 Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity. arsenite 18-26 tumor protein p53 Homo sapiens 80-83 32373892-6 2020 We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity. arsenite 143-151 tumor protein p53 Homo sapiens 127-130 32373892-6 2020 We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity. arsenite 228-236 tumor protein p53 Homo sapiens 127-130 32373892-6 2020 We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity. arsenite 228-236 tumor protein p53 Homo sapiens 275-278 32373892-7 2020 Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway. arsenite 69-77 tumor protein p53 Homo sapiens 202-205 32373892-8 2020 Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer. arsenite 63-71 tumor protein p53 Homo sapiens 125-128 32265434-6 2020 Taken together, we conclude that IKKalpha attenuates arsenite-induced apoptosis by inducing p53-dependent autophagy, and then selective feedback degradation of IKKalpha by autophagy contributes to the cytotoxic response induced by arsenite. arsenite 53-61 tumor protein p53 Homo sapiens 92-95 31931413-0 2020 N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation. arsenite 28-36 tumor protein p53 Homo sapiens 94-97 31931413-10 2020 Taken together, our study revealed the novel role of m6A in mediating arsenite-induced human keratinocyte transformation by suppressing p53 activation. arsenite 70-78 tumor protein p53 Homo sapiens 136-139 30177839-0 2019 Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis. arsenite 48-56 tumor protein p53 Homo sapiens 41-44 30177839-4 2019 Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction. arsenite 0-8 tumor protein p53 Homo sapiens 48-51 30177839-6 2019 Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents. arsenite 199-207 tumor protein p53 Homo sapiens 69-72 28785074-0 2017 Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes. arsenite 9-17 tumor protein p53 Homo sapiens 65-68 28785074-4 2017 We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53. arsenite 112-120 tumor protein p53 Homo sapiens 139-142 28785074-4 2017 We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53. arsenite 112-120 tumor protein p53 Homo sapiens 220-223 28785074-7 2017 In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased. arsenite 52-60 tumor protein p53 Homo sapiens 188-191 28785074-9 2017 Taken together, our results demonstrated that low-dose arsenite-induced resistance to apoptosis through p53 mediated by MDM2 in keratinocytes. arsenite 55-63 tumor protein p53 Homo sapiens 104-107