PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15163543-5 2004 On the other hand, arsenite has high affinity for sulfhydryl groups and thus can form covalent bonds with the disulfide bridges in the molecules of insulin, insulin receptors, glucose transporters (GLUTs), and enzymes involved in glucose metabolism (e.g., pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase). arsenite 19-27 insulin Homo sapiens 148-155 15276423-5 2004 In contrast, trivalent arsenicals, arsenite (iAs(III)), methylarsine oxide (MAs(III)O), and iododimethylarsine (DMAs(III)O) inhibited insulin-stimulated glucose uptake in a concentration-dependent manner. arsenite 35-43 insulin Homo sapiens 134-141 15163543-5 2004 On the other hand, arsenite has high affinity for sulfhydryl groups and thus can form covalent bonds with the disulfide bridges in the molecules of insulin, insulin receptors, glucose transporters (GLUTs), and enzymes involved in glucose metabolism (e.g., pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase). arsenite 19-27 insulin Homo sapiens 157-164 15163543-12 2004 Arsenite at physiologically relevant concentration also shows inhibitory effect on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor important for activating insulin action. arsenite 0-8 insulin Homo sapiens 215-222 24535192-0 2014 Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling. arsenite 31-39 insulin Homo sapiens 70-77 14511371-3 2003 By subcellular fractionation we observed that arsenite, like insulin, induces translocation of the GLUT1 and GLUT4 glucose transporters from the low-density membrane fraction to the plasma membrane. arsenite 46-54 insulin Homo sapiens 61-68 14511371-10 2003 Arsenite- and insulin-induced glucose uptake responded in a remarkably similar dose-dependent fashion to a range of pharmacological- and peptide-inhibitors for atypical PKC-lambda, a downstream target of PI-3" kinase signalling in insulin-induced glucose uptake. arsenite 0-8 insulin Homo sapiens 231-238 33743404-9 2021 For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane. arsenite 32-40 insulin Homo sapiens 4-11 33743404-10 2021 For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA. arsenite 145-153 insulin Homo sapiens 4-11 33743404-11 2021 In insulin-treated L-02 cells, miR-191, via IRS1, was involved in the arsenite-induced decreases of glucose consumption and glycogen levels and in inhibition of the translocation of GLUT4. arsenite 70-78 insulin Homo sapiens 3-10 30261343-6 2019 FOXO1 nuclear exclusion elicited by insulin or xenobiotics such as arsenite or copper ions was attenuated by DEM, suggesting that DEM interfered with nuclear export. arsenite 67-75 insulin Homo sapiens 36-43 24535192-4 2014 The present study aimed at investigating the effect of short and long-term exposure to arsenite on insulin signaling in HepG2 human hepatoma cells, the role of PI3K/Akt signaling therein and the modulation of target genes controlled by insulin. arsenite 87-95 insulin Homo sapiens 99-106 24535192-5 2014 Exposure of cells to arsenite for 24 h rendered cells less responsive toward stimulation of Akt by insulin. arsenite 21-29 insulin Homo sapiens 99-106 24535192-12 2014 In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity. arsenite 15-23 insulin Homo sapiens 132-139 24535192-12 2014 In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity. arsenite 15-23 insulin Homo sapiens 176-183 20082316-3 2010 In present work, we show that insulin signaling, probably through the IGF-I receptor, is required for the increase in cell size accompanying differentiation and that this is opposed by arsenite. arsenite 185-193 insulin Homo sapiens 30-37 24535192-12 2014 In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity. arsenite 15-23 insulin Homo sapiens 176-183 23603037-6 2013 Overall results suggested that both insulin and NIn improved mitochondrial functioning in arsenite-intoxicated L6 cells, NIn showing better effects at a much lower dose (at nearly 10-fold decreased dose) than that produced by insulin. arsenite 90-98 insulin Homo sapiens 36-43 21396911-0 2011 Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. arsenite 20-28 insulin Homo sapiens 49-56 20082316-4 2010 We further examine the impact of insulin and arsenite on PKCdelta, a known key regulator of keratinocyte differentiation, and show that insulin increases the amount, tyrosine phosphorylation, and membrane localization of PKCdelta. arsenite 45-53 insulin Homo sapiens 136-143 20082316-5 2010 All these effects are prevented by exposure of cells to arsenite or to inhibitors of downstream effectors of insulin (phosphotidylinositol 3-kinase and mammalian target of rapamycin). arsenite 56-64 insulin Homo sapiens 109-116 20082316-9 2010 Finally, inhibiting epidermal growth factor receptor kinase activity diminished the ability of arsenite to prevent cell enlargement and to suppress insulin-dependent PKCdelta amount and tyrosine 311 phosphorylation. arsenite 95-103 insulin Homo sapiens 148-155 17400267-8 2007 A novel finding is that insulin in the medium induced the loss of EGF receptor protein, which was largely prevented by arsenite exposure. arsenite 119-127 insulin Homo sapiens 24-31 17520061-0 2007 Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid. arsenite 96-104 insulin Homo sapiens 75-82 17520061-3 2007 We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). arsenite 60-68 insulin Homo sapiens 123-130 17520061-3 2007 We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). arsenite 60-68 insulin Homo sapiens 204-211 20467584-3 2008 We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane. arsenite 28-36 insulin Homo sapiens 76-83 20467584-3 2008 We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane. arsenite 28-36 insulin Homo sapiens 147-154 20467584-3 2008 We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane. arsenite 28-36 insulin Homo sapiens 147-154