PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29528074-8 2018 The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38. arsenite 71-79 mitogen-activated protein kinase 1 Homo sapiens 114-117 29528074-8 2018 The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38. arsenite 71-79 mitogen-activated protein kinase 1 Homo sapiens 128-131 25493652-4 2015 Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities. arsenite 84-92 mitogen-activated protein kinase 1 Homo sapiens 301-304 27347121-7 2016 To further examine the differences between these two cell lines, the effect of arsenite on upstream p44/p42 mitogen-activated protein kinase (MAPK) and Akt was investigated. arsenite 79-87 mitogen-activated protein kinase 1 Homo sapiens 142-146 25493652-5 2015 The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway. arsenite 4-12 mitogen-activated protein kinase 1 Homo sapiens 154-157 25493652-8 2015 These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes. arsenite 27-35 mitogen-activated protein kinase 1 Homo sapiens 104-107 29528074-0 2018 Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 116-119 27071941-0 2016 Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 35-38 27107786-0 2016 MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells. arsenite 64-72 mitogen-activated protein kinase 1 Homo sapiens 26-29 27107786-5 2016 Arsenite also activates the ERK pathway in a dose- and time-dependent manner. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 28-31 27107786-9 2016 Also, ERK promotes the autophagy induced by arsenite. arsenite 44-52 mitogen-activated protein kinase 1 Homo sapiens 6-9 27107786-10 2016 In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy. arsenite 34-42 mitogen-activated protein kinase 1 Homo sapiens 80-83 27107786-10 2016 In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy. arsenite 126-134 mitogen-activated protein kinase 1 Homo sapiens 80-83 25493652-4 2015 Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities. arsenite 84-92 mitogen-activated protein kinase 1 Homo sapiens 357-360 25412313-3 2014 Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation. arsenite 133-141 mitogen-activated protein kinase 1 Homo sapiens 182-185 25412313-8 2014 Taken together, our findings provided strong evidence showing that by targeting Ras/ERK pathway, p27 provided a negative control over HIF-1alpha protein synthesis in an S6-dependent manner, and abrogated arsenite-induced cell transformation via downregulation of HIF-1alpha translation. arsenite 204-212 mitogen-activated protein kinase 1 Homo sapiens 84-87 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 1 Homo sapiens 24-27 24934751-6 2014 As expected, HO-1 RNAi knockdown, or ERK/AP1 inhibition, renders the Beas-2B cells more sensitive to arsenite damage. arsenite 101-109 mitogen-activated protein kinase 1 Homo sapiens 37-40 24934751-7 2014 Our data thus suggest that transcriptional upregulation of HO-1 expression via a putative ERK/AP-1 pathway constitutes an inherent mechanism by which arsenite-induced apoptosis is attenuated. arsenite 150-158 mitogen-activated protein kinase 1 Homo sapiens 90-93 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 1 Homo sapiens 84-87 23566955-7 2013 BMP also greatly decreased active ERK, while co-treatment with arsenite maintained active ERK. arsenite 63-71 mitogen-activated protein kinase 1 Homo sapiens 90-93 23566955-8 2013 Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite. arsenite 129-137 mitogen-activated protein kinase 1 Homo sapiens 14-17 23566955-9 2013 Of 6 dual-specificity phosphatases (DUSPs) targeting ERK, two were induced by BMP unless prevented by simultaneous exposure to arsenite and EGF. arsenite 127-135 mitogen-activated protein kinase 1 Homo sapiens 53-56 23566955-13 2013 Arsenite prevents this cascade by maintaining ERK signaling, at least in part by suppressing DUSP expression. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 46-49 23469214-7 2013 Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively. arsenite 76-84 mitogen-activated protein kinase 1 Homo sapiens 121-124 23194660-0 2013 The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. arsenite 126-134 mitogen-activated protein kinase 1 Homo sapiens 58-61 23194660-4 2013 Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells. arsenite 37-45 mitogen-activated protein kinase 1 Homo sapiens 56-94 23194660-4 2013 Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells. arsenite 37-45 mitogen-activated protein kinase 1 Homo sapiens 96-99 23194660-4 2013 Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells. arsenite 125-133 mitogen-activated protein kinase 1 Homo sapiens 56-94 23194660-4 2013 Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells. arsenite 125-133 mitogen-activated protein kinase 1 Homo sapiens 96-99 23194660-5 2013 ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2alpha. arsenite 67-75 mitogen-activated protein kinase 1 Homo sapiens 0-3 23194660-8 2013 Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. arsenite 143-151 mitogen-activated protein kinase 1 Homo sapiens 103-106 23469214-7 2013 Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively. arsenite 76-84 mitogen-activated protein kinase 1 Homo sapiens 193-196 17334397-3 2007 Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent. arsenite 26-34 mitogen-activated protein kinase 1 Homo sapiens 14-17 23469214-9 2013 CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells. arsenite 209-217 mitogen-activated protein kinase 1 Homo sapiens 81-84 22387281-9 2012 Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation. arsenite 71-79 mitogen-activated protein kinase 1 Homo sapiens 102-105 22387281-9 2012 Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation. arsenite 71-79 mitogen-activated protein kinase 1 Homo sapiens 192-195 22387281-10 2012 Overexpression of miR-21 with an miR-21 mimic and feedback activation of ERK and NF-kappaB via the decrease in Spry1 promoted the malignancy of HELF cells exposed to arsenite, but knockdown of miR-21 with anti-miR-21 and feedback blockage of ERK and NF-kappaB activation through an increase in Spry1 decreased anchorage-independent growth of arsenite-transformed cells. arsenite 166-174 mitogen-activated protein kinase 1 Homo sapiens 73-76 22387281-11 2012 Thus, the transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, is mediated by reactive oxygen species activation of the ERK/NF-kappaB pathway. arsenite 70-78 mitogen-activated protein kinase 1 Homo sapiens 196-199 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 10-18 mitogen-activated protein kinase 1 Homo sapiens 40-43 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 10-18 mitogen-activated protein kinase 1 Homo sapiens 164-167 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 238-246 mitogen-activated protein kinase 1 Homo sapiens 40-43 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 238-246 mitogen-activated protein kinase 1 Homo sapiens 164-167 22387281-0 2012 Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-kappaB in arsenite-induced cell transformation. arsenite 77-85 mitogen-activated protein kinase 1 Homo sapiens 60-63 22387281-5 2012 During arsenite-induced transformation of human embryo lung fibroblast (HELF) cells, miR-21 was upregulated, and the extracellular signal-regulated kinase (ERK)/nuclear factor-kappaB (NF-kappaB) signal pathway was activated. arsenite 7-15 mitogen-activated protein kinase 1 Homo sapiens 156-159 22387281-7 2012 Blockage of ERK by the inhibitor U0126 or inhibition of NF-kappaB p65 by siRNA or Bay 11-7082 prevented the increases in miR-21 and the decreases in Spry1, Pten, and Pdcd4, the target proteins of miR-21, induced by arsenite. arsenite 215-223 mitogen-activated protein kinase 1 Homo sapiens 12-15 17334397-3 2007 Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent. arsenite 26-34 mitogen-activated protein kinase 1 Homo sapiens 200-203 15504454-3 2004 In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line. arsenite 133-141 mitogen-activated protein kinase 1 Homo sapiens 49-86 15504345-6 2004 The essential role of the p38 pathway in up-regulation of VDR expression was further confirmed by using the p38 stimulator arsenite. arsenite 123-131 mitogen-activated protein kinase 1 Homo sapiens 26-29 15504345-6 2004 The essential role of the p38 pathway in up-regulation of VDR expression was further confirmed by using the p38 stimulator arsenite. arsenite 123-131 mitogen-activated protein kinase 1 Homo sapiens 108-111 17196236-9 2007 Cooperation between ERK signaling and ROS generation was demonstrated by synergistic induction of HO-1 in cells co-treated with EGF and xanthine/xanthine oxidase resulting in a response nearly equivalent to that observed with arsenite. arsenite 226-234 mitogen-activated protein kinase 1 Homo sapiens 20-23 17196236-10 2007 These findings suggest that the ERK/MAPK activation is necessary but not sufficient for optimal arsenite-stimulated HO-1 induction. arsenite 96-104 mitogen-activated protein kinase 1 Homo sapiens 32-35 16008523-10 2005 The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor. arsenite 4-12 mitogen-activated protein kinase 1 Homo sapiens 76-79 16008523-10 2005 The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor. arsenite 4-12 mitogen-activated protein kinase 1 Homo sapiens 81-118 16008523-10 2005 The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor. arsenite 4-12 mitogen-activated protein kinase 1 Homo sapiens 185-188 15580309-4 2005 We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas. arsenite 26-34 mitogen-activated protein kinase 1 Homo sapiens 134-138 15580309-4 2005 We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas. arsenite 26-34 mitogen-activated protein kinase 1 Homo sapiens 192-195 15580309-5 2005 Since EGFR signaling operates via activation of the PI3K-AKT and MEK-ERK pathways, we suggested that the combination of arsenite and EGFR inhibitors might also effectively induce apoptosis in melanoma. arsenite 120-128 mitogen-activated protein kinase 1 Homo sapiens 69-72 15580309-7 2005 In contrast, induction of apoptosis in melanomas with negligible surface expression of EGFR or with defective EGFR signaling requires direct suppression of the PI3K-AKT and MAPK pathways by specific pharmacological inhibitors in the presence of arsenite. arsenite 245-253 mitogen-activated protein kinase 1 Homo sapiens 173-177 16121039-9 2005 We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite. arsenite 157-165 mitogen-activated protein kinase 1 Homo sapiens 36-40 16121039-9 2005 We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite. arsenite 157-165 mitogen-activated protein kinase 1 Homo sapiens 53-56 15504454-3 2004 In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line. arsenite 133-141 mitogen-activated protein kinase 1 Homo sapiens 88-91 15504454-4 2004 Arsenite concentrations > or =100 microM stimulate rapid activation of p38 and ERK MAP kinases. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 82-85 15504454-5 2004 However, upon extended exposure (24 h), persistent stimulation of p38 and ERK MAP kinases was detected at low micromolar concentrations of arsenite. arsenite 139-147 mitogen-activated protein kinase 1 Homo sapiens 74-77 15504454-7 2004 ERK activation by arsenite was fully dependent on the catalytic activity of the epidermal growth factor (EGF) receptor and partially dependent on Src-family kinase activity. arsenite 18-26 mitogen-activated protein kinase 1 Homo sapiens 0-3 15028728-6 2004 On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells. arsenite 140-148 mitogen-activated protein kinase 1 Homo sapiens 96-99 15153785-5 2004 Treatment of BHV-4-infected BAE cells with either U0126, a potent inhibitor of MAPK/ERK kinase, or arsenite dose-dependently blocked ERK activation and inhibited viral DNA synthesis and viral replication in the culture. arsenite 99-107 mitogen-activated protein kinase 1 Homo sapiens 133-136 14514659-4 2004 Our results indicate a molecular mechanism by which MAPK pathways might differentially contribute to cell growth regulation and cell death in response to different dosages of arsenite. arsenite 175-183 mitogen-activated protein kinase 1 Homo sapiens 52-56 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 27-35 mitogen-activated protein kinase 1 Homo sapiens 47-84 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 27-35 mitogen-activated protein kinase 1 Homo sapiens 86-89 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 27-35 mitogen-activated protein kinase 1 Homo sapiens 168-171 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 151-159 mitogen-activated protein kinase 1 Homo sapiens 47-84 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 151-159 mitogen-activated protein kinase 1 Homo sapiens 86-89 14514659-5 2004 A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059. arsenite 151-159 mitogen-activated protein kinase 1 Homo sapiens 168-171 12547826-5 2003 We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation. arsenite 51-59 mitogen-activated protein kinase 1 Homo sapiens 150-153 12547826-7 2003 Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway. arsenite 60-68 mitogen-activated protein kinase 1 Homo sapiens 195-198 12464623-0 2003 Cross-linking of surface IgM in the Burkitt"s lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways. arsenite 99-107 mitogen-activated protein kinase 1 Homo sapiens 158-161 12464623-5 2003 We examined the question of whether IgM-mediated activation of the ERK and PI3K pathways can influence the apoptotic response of ST486 cells following exposure to arsenite and selected drugs with different molecular targets, including cycloheximide, etoposide, and camptothecin, and a physical stress, hyperthermia. arsenite 163-171 mitogen-activated protein kinase 1 Homo sapiens 67-70 10329651-0 1999 Requirement of Erk, but not JNK, for arsenite-induced cell transformation. arsenite 37-45 mitogen-activated protein kinase 1 Homo sapiens 15-18 10329651-4 1999 Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK. arsenite 15-23 mitogen-activated protein kinase 1 Homo sapiens 32-35 10329651-4 1999 Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK. arsenite 15-23 mitogen-activated protein kinase 1 Homo sapiens 66-69 10329651-5 1999 Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 17-20 10329651-5 1999 Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 92-96 10329651-6 1999 Furthermore, arsenite-induced cell transformation was blocked in cells expressing the dominant negative Erk2. arsenite 13-21 mitogen-activated protein kinase 1 Homo sapiens 104-108 10329651-8 1999 Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. arsenite 31-39 mitogen-activated protein kinase 1 Homo sapiens 48-51 10329651-8 1999 Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. arsenite 31-39 mitogen-activated protein kinase 1 Homo sapiens 124-127 10329651-8 1999 Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation. arsenite 145-153 mitogen-activated protein kinase 1 Homo sapiens 124-127 14674888-0 2003 Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 31-73 14516795-2 2003 Arsenite treatment resulted in the persistent activation of p70(s6k) and extracellular signal-regulated kinase 1/2 (ERK1/2) which was accompanied by an increase in intracellular ROS production. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 73-114 12426127-5 2002 Arsenite induces phosphorylation of extracellular signal-regulated protein kinases (Erks) and c-Jun NH(2)-terminal kinases (JNKs). arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 84-88 12426127-6 2002 Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 17-20 12426127-6 2002 Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 92-96 12426127-6 2002 Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 92-95 12426127-7 2002 Furthermore, arsenite-induced cell transformation was blocked in cells expressing dominant-negative Erk2. arsenite 13-21 mitogen-activated protein kinase 1 Homo sapiens 100-104 11259586-4 2001 In contrast, activation of stress-activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta-activated kinase 1 (TAK1), MAPK kinase 3 (MKK3), or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity. arsenite 250-258 mitogen-activated protein kinase 1 Homo sapiens 72-75 11259586-6 2001 Activation of p38 MAPK by arsenite also potently abrogated stimulation of MMP-1 gene expression by constitutively active Ras and Raf-1 and by phorbol ester. arsenite 26-34 mitogen-activated protein kinase 1 Homo sapiens 14-17 11259586-8 2001 Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A. arsenite 13-21 mitogen-activated protein kinase 1 Homo sapiens 128-131 9442025-0 1998 The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. arsenite 19-27 mitogen-activated protein kinase 1 Homo sapiens 139-142 9442025-3 1998 We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics. arsenite 47-55 mitogen-activated protein kinase 1 Homo sapiens 66-103 9442025-3 1998 We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics. arsenite 47-55 mitogen-activated protein kinase 1 Homo sapiens 105-108 9442025-3 1998 We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics. arsenite 47-55 mitogen-activated protein kinase 1 Homo sapiens 125-128 9442025-4 1998 Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines. arsenite 135-143 mitogen-activated protein kinase 1 Homo sapiens 8-11 9442025-4 1998 Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines. arsenite 135-143 mitogen-activated protein kinase 1 Homo sapiens 41-44 9442025-4 1998 Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines. arsenite 135-143 mitogen-activated protein kinase 1 Homo sapiens 126-129 9442025-6 1998 Arsenite-induced ERK activation is mediated by Ras, Raf, and MEK but appears to be independent of de novo protein synthesis. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 17-20 32683294-0 2020 Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. arsenite 0-8 mitogen-activated protein kinase 1 Homo sapiens 89-92