PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23069812-0 2013 EMT and CSC-like properties mediated by the IKKbeta/IkappaBalpha/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes. arsenite 147-155 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 44-51 23069812-7 2013 These observations show that EMT, along with acquisition of a CSC-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis. arsenite 183-191 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 93-100 30177839-6 2019 Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents. arsenite 199-207 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 79-86 22824620-5 2012 Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite. arsenite 192-200 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 102-109 22824620-6 2012 Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression. arsenite 61-69 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 104-111 16230390-5 2005 The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition. arsenite 30-38 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 195-202 16230390-8 2005 Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway. arsenite 38-46 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 109-116 10967126-7 2000 The addition of 1,2-dithiol antidotes or replacement of Cys-179 with an alanine residue abolished dye binding to and arsenite inhibition of IKKbeta. arsenite 117-125 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 140-147 10967126-8 2000 Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits. arsenite 72-80 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 18-25 10967126-8 2000 Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits. arsenite 232-240 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 18-25 21688155-0 2011 IKKbeta downregulation is critical for triggering JNKs-dependent cell apoptotic response in the human hepatoma cells under arsenite exposure. arsenite 123-131 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 0-7 21688155-4 2011 We found that arsenite exposure induced JNKs and AP-1 activation accompanying with a significant reduction of both IKKalpha and IKKbeta expressions. arsenite 14-22 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 128-135 21688155-5 2011 Overexpression of IKKbeta, but not of IKKalpha, inhibited arsenite-induced MKK7/JNKs/AP-1 pathway activation as well as the apoptotic response. arsenite 58-66 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 18-25 21688155-6 2011 Therefore, we conclude that the downregulation of IKKbeta expression is the prerequisite signaling event for mediating JNKs pathway activation and the cellular apoptotic response in the HepG2 cells under arsenite exposure. arsenite 205-213 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 51-58 21688155-7 2011 Targeting IKKbeta might be helpful to enhance the tumor therapeutic effect of arsenite. arsenite 78-86 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 10-17 17116751-0 2006 IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. arsenite 105-113 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 0-7 17116751-3 2006 We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. arsenite 254-262 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 56-75 17116751-3 2006 We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. arsenite 254-262 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 77-84 17079871-2 2006 Cys-179 in the activation loop of IKKbeta is known to be the target site for IKK inhibitors such as cyclopentenone prostaglandins, arsenite, and antirheumatic gold compounds. arsenite 131-139 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 34-41 17079871-2 2006 Cys-179 in the activation loop of IKKbeta is known to be the target site for IKK inhibitors such as cyclopentenone prostaglandins, arsenite, and antirheumatic gold compounds. arsenite 131-139 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 34-37 30177839-0 2019 Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis. arsenite 48-56 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 30-37 30177839-4 2019 Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction. arsenite 0-8 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 146-153 24751519-0 2014 IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response. arsenite 65-73 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 0-8 24751519-3 2014 We here explored the inhibitory regulation of IKKbeta on p27(Kip1) expression following arsenite exposure. arsenite 88-96 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 46-53 24751519-7 2014 Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure. arsenite 54-62 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 118-125