PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20375080-5	2010	In arsenite-exposed cells, the levels of phospho-p53, p21, and mdm2 increase at early times after exposure.	arsenite	3-11	MDM2 proto-oncogene	Homo sapiens	63-67	
23563151-0	2013	Ribosomal protein S7 regulates arsenite-induced GADD45alpha expression by attenuating MDM2-mediated GADD45alpha ubiquitination and degradation.	arsenite	31-39	MDM2 proto-oncogene	Homo sapiens	86-90	
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	MDM2 proto-oncogene	Homo sapiens	69-73	
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	MDM2 proto-oncogene	Homo sapiens	115-119	
19010883-3	2008	Through the mitogen-activated protein kinase pathway, arsenite stimulates the P2 promoter-mediated expression of Hdm2, which then promotes p53 nuclear export.	arsenite	54-62	MDM2 proto-oncogene	Homo sapiens	113-117	
11813266-5	2002	P53, p21, and MDM2 were induced in E6-transfected TK6 cells, as well as in parental TK6 cells after arsenite treatment.	arsenite	100-108	MDM2 proto-oncogene	Homo sapiens	14-18	
10491313-4	1999	Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	86-90	
28785074-7	2017	In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased.	arsenite	52-60	MDM2 proto-oncogene	Homo sapiens	69-73	
30177839-2	2019	Arsenite exposure induces ribosomal stress responses mediated by the ribosomal protein S7, which can block MDM2 activity and result in GADD45alpha accumulation and cell apoptosis.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	107-111	
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	177-181	
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	241-245	
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	MDM2 proto-oncogene	Homo sapiens	87-91	
28785074-0	2017	Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes.	arsenite	9-17	MDM2 proto-oncogene	Homo sapiens	69-73	
28785074-6	2017	Moreover, low-dose arsenite treatment dramatically decreased the MDM2 gene promoter activity, suggesting that this effect has been mediated through transcription.	arsenite	19-27	MDM2 proto-oncogene	Homo sapiens	65-69	
34425169-9	2021	A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function.	arsenite	54-62	MDM2 proto-oncogene	Homo sapiens	109-113	
28785074-9	2017	Taken together, our results demonstrated that low-dose arsenite-induced resistance to apoptosis through p53 mediated by MDM2 in keratinocytes.	arsenite	55-63	MDM2 proto-oncogene	Homo sapiens	120-124