PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30713663-4 2019 The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level. arsenite 62-70 caspase 3 Homo sapiens 135-144 31468445-7 2019 Taurine also reversed the arsenite-induced increase in caspase-3 activity. arsenite 26-34 caspase 3 Homo sapiens 55-64 23824679-10 2013 At the same time, arsenite-induced caspase 3 activation and neuronal death were attenuated in the HO-1 siRNA-transfected cells. arsenite 18-26 caspase 3 Homo sapiens 35-44 23824679-3 2013 Furthermore, arsenite induced caspase 3 activation and decreased procaspase 12 levels, indicating that apoptosis is involved in the arsenite-induced neurotoxicity. arsenite 13-21 caspase 3 Homo sapiens 30-39 22260869-1 2012 Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels. arsenite 0-8 caspase 3 Homo sapiens 84-93 23824679-6 2013 Co-incubation with glutathione (10 mM) attenuated arsenite-induced HO-1 elevation and caspase 3 activation, suggesting that oxidative stress is involved in the arsenite-induced neurotoxicity. arsenite 160-168 caspase 3 Homo sapiens 86-95 23824679-7 2013 The neurotoxic effects of inorganic arsenics were compared; arsenite was more potent than arsenate in inducing HO-1 expression and caspase 3 activation. arsenite 60-68 caspase 3 Homo sapiens 131-140 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 113-121 caspase 3 Homo sapiens 146-155 22260869-2 2012 Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death. arsenite 239-247 caspase 3 Homo sapiens 146-155 18715270-9 2009 At the same time, melatonin inhibited arsenite-induced activation of caspase 3 in the treated DRG explants. arsenite 38-46 caspase 3 Homo sapiens 69-78 20302512-4 2010 Arsenite treatment induced autophagosome formation and permeabilization of mitochondria, followed by caspase 3/7-mediated apoptosis. arsenite 0-8 caspase 3 Homo sapiens 101-110 17849503-4 2008 Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP). arsenite 44-52 caspase 3 Homo sapiens 181-190 17849503-4 2008 Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP). arsenite 89-97 caspase 3 Homo sapiens 181-190 17849503-5 2008 Two selective GSK3 inhibitors, lithium and SB216763, attenuated caspase-3 activation and PARP cleavage induced by arsenite treatment indicating that GSK3 contributed to arsenite-induced apoptosis. arsenite 114-122 caspase 3 Homo sapiens 64-73 18077580-7 2007 In the mitochondrial pathway, NAC attenuated arsenite-induced elevation in Bcl-2 level and cytosolic cytochrome c, as well as arsenite-induced reduction in procaspase-3 levels. arsenite 126-134 caspase 3 Homo sapiens 156-168 10930531-4 2000 After release from arsenite treatment, more than 80% of arsenite-arrested mitotic cells subsequently underwent apoptosis, as indicated by anachronistic nuclear envelope reformation, DNA ladder occurrence, chromatin condensation, and activation of caspases 3 and 9. arsenite 19-27 caspase 3 Homo sapiens 247-263 16614167-6 2006 Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe. arsenite 72-80 caspase 3 Homo sapiens 38-47 16447264-7 2006 Assays of cell viability and caspase showed that arsenite caused a dose-dependent increase in cell death by activation of caspase 3/7 and pre-induction of HSPs blunted these effects. arsenite 49-57 caspase 3 Homo sapiens 122-131 16114012-7 2006 Neutralization of intracellular HSP27 with its antibody reduced arsenite"s inhibition of UVB-induced caspase3 activation. arsenite 64-72 caspase 3 Homo sapiens 101-109 12946653-4 2003 Here we demonstrated that arsenite exposure induced apoptosis accompanied by the occurrence of apoptotic signals including degradation of poly(ADP-ribose) polymerase (PARP) and CPP32 (cleavage/activation) and DNA ladder formation. arsenite 26-34 caspase 3 Homo sapiens 177-182 11813266-8 2002 After arsenite treatment, TK6-E6 cells showed more sub-G1 apoptosis, activated caspase-3/CPP32 fragment, DNA ladder, and less viability than parental TK6 cells, indicating that arsenite enhanced apoptosis in E6-transfected TK6 cells. arsenite 177-185 caspase 3 Homo sapiens 79-88 11813266-8 2002 After arsenite treatment, TK6-E6 cells showed more sub-G1 apoptosis, activated caspase-3/CPP32 fragment, DNA ladder, and less viability than parental TK6 cells, indicating that arsenite enhanced apoptosis in E6-transfected TK6 cells. arsenite 177-185 caspase 3 Homo sapiens 89-94 11046111-11 2000 Arsenite-induced apoptosis was caspase-3 dependent. arsenite 0-8 caspase 3 Homo sapiens 31-40 10930531-4 2000 After release from arsenite treatment, more than 80% of arsenite-arrested mitotic cells subsequently underwent apoptosis, as indicated by anachronistic nuclear envelope reformation, DNA ladder occurrence, chromatin condensation, and activation of caspases 3 and 9. arsenite 56-64 caspase 3 Homo sapiens 247-263 9766529-0 1998 Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. arsenite 67-75 caspase 3 Homo sapiens 43-52 9766529-7 1998 Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32. arsenite 147-155 caspase 3 Homo sapiens 14-19 9766529-7 1998 Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32. arsenite 147-155 caspase 3 Homo sapiens 273-278 9766529-7 1998 Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32. arsenite 196-204 caspase 3 Homo sapiens 14-19 9766529-8 1998 These results lead to a working hypothesis that arsenite-induced apoptosis is triggered by the generation of hydrogen peroxide through activation of flavoprotein-dependent superoxide-producing enzymes (such as NADPH oxidase), and hydrogen peroxide might play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation. arsenite 48-56 caspase 3 Homo sapiens 358-363 34861471-4 2022 Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax. arsenite 0-8 caspase 3 Homo sapiens 192-201