PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26432159-0 2015 Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy. arsenite 80-88 mitogen-activated protein kinase 3 Homo sapiens 34-40 14516795-2 2003 Arsenite treatment resulted in the persistent activation of p70(s6k) and extracellular signal-regulated kinase 1/2 (ERK1/2) which was accompanied by an increase in intracellular ROS production. arsenite 0-8 mitogen-activated protein kinase 3 Homo sapiens 116-122 14516795-4 2003 Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways. arsenite 73-81 mitogen-activated protein kinase 3 Homo sapiens 117-123 14516795-4 2003 Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways. arsenite 73-81 mitogen-activated protein kinase 3 Homo sapiens 217-223 14516795-6 2003 While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2. arsenite 103-111 mitogen-activated protein kinase 3 Homo sapiens 136-142 14516795-6 2003 While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2. arsenite 103-111 mitogen-activated protein kinase 3 Homo sapiens 282-288 14516795-6 2003 While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2. arsenite 157-165 mitogen-activated protein kinase 3 Homo sapiens 136-142 11259586-8 2001 Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A. arsenite 13-21 mitogen-activated protein kinase 3 Homo sapiens 73-79 11322385-8 2001 Overexpression of a dominant negative mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) prevents arsenite-induced ERK1/2 phosphorylation and HSP70 protein synthesis. arsenite 117-125 mitogen-activated protein kinase 3 Homo sapiens 134-140 9442025-0 1998 The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. arsenite 19-27 mitogen-activated protein kinase 3 Homo sapiens 72-118 9442025-0 1998 The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. arsenite 19-27 mitogen-activated protein kinase 3 Homo sapiens 125-129 28501331-0 2017 The expression of keratin 6 is regulated by the activation of the ERK1/2 pathway in arsenite transformed human urothelial cells. arsenite 84-92 mitogen-activated protein kinase 3 Homo sapiens 66-72 14674888-16 2003 CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK. arsenite 41-49 mitogen-activated protein kinase 3 Homo sapiens 97-103 14516795-8 2003 DNA binding activity of AP-1, downstream of ERK1/2, was also inhibited by catalase, N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2. arsenite 164-172 mitogen-activated protein kinase 3 Homo sapiens 44-50 14516795-8 2003 DNA binding activity of AP-1, downstream of ERK1/2, was also inhibited by catalase, N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2. arsenite 164-172 mitogen-activated protein kinase 3 Homo sapiens 187-193 14516795-9 2003 Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways. arsenite 65-73 mitogen-activated protein kinase 3 Homo sapiens 203-209 14516795-9 2003 Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways. arsenite 168-176 mitogen-activated protein kinase 3 Homo sapiens 203-209 26432159-7 2015 Our previous work showed that arsenite induced phosphorylation of the ERK1/2 signaling pathway. arsenite 30-38 mitogen-activated protein kinase 3 Homo sapiens 70-76 26432159-10 2015 These results show that autophagy induced by arsenite exposure is mediated by oxidative stress, which regulates activation of the PTEN, p70S6K and ERK1/2 signaling pathways. arsenite 45-53 mitogen-activated protein kinase 3 Homo sapiens 147-153 21167264-13 2011 In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells. arsenite 51-59 mitogen-activated protein kinase 3 Homo sapiens 176-182 25145660-12 2014 Both arsenite and MMA (III) significantly inhibited Erk1/2 and Erk5 phosphorylation. arsenite 5-13 mitogen-activated protein kinase 3 Homo sapiens 52-58 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 3 Homo sapiens 16-22 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 3 Homo sapiens 73-79 23968725-7 2013 It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions. arsenite 64-72 mitogen-activated protein kinase 3 Homo sapiens 99-103 23968725-8 2013 In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells. arsenite 15-23 mitogen-activated protein kinase 3 Homo sapiens 143-147 21971544-0 2011 Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. arsenite 0-8 mitogen-activated protein kinase 3 Homo sapiens 70-76 23618899-9 2013 In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells. arsenite 15-23 mitogen-activated protein kinase 3 Homo sapiens 72-78 20862710-0 2010 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. arsenite 130-138 mitogen-activated protein kinase 3 Homo sapiens 31-37 19577553-6 2009 In the present study, we demonstrate that arsenite can activate the extracellular signaling-regulated protein kinase 1/2 (ERK1/2) signaling pathway after treatment in SV-HUC-1 cells by using immunocytochemistry and Western blotting. arsenite 42-50 mitogen-activated protein kinase 3 Homo sapiens 122-128 19577553-9 2009 When the cells were pretreated with inhibitors 5-aza-CdR or U0126 for 24h, the effect of arsenite on ERK1/2, LC3B, Beclin-1 and DAPK proteins expression is suppressed. arsenite 89-97 mitogen-activated protein kinase 3 Homo sapiens 101-107 19577553-10 2009 Furthermore, our results support the notion that arsenite can induce the ERK1/2 signaling pathway to stimulate autophagy and DAPK promoter hypermethylation in human uroepithelial SV-HUC-1 cells. arsenite 49-57 mitogen-activated protein kinase 3 Homo sapiens 73-79 17334397-3 2007 Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent. arsenite 26-34 mitogen-activated protein kinase 3 Homo sapiens 67-73 17334397-3 2007 Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent. arsenite 26-34 mitogen-activated protein kinase 3 Homo sapiens 231-237 17289100-0 2007 Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells. arsenite 19-27 mitogen-activated protein kinase 3 Homo sapiens 109-115 17289100-3 2007 In the present study, we aimed at investigating the relationship between biphasic effect of arsenite on cell proliferation and apoptosis and activation of JNK and ERK1/2 in human embryo lung fibroblast (HELF) cells. arsenite 92-100 mitogen-activated protein kinase 3 Homo sapiens 163-169 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 86-94 mitogen-activated protein kinase 3 Homo sapiens 8-14 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 86-94 mitogen-activated protein kinase 3 Homo sapiens 166-172 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 238-246 mitogen-activated protein kinase 3 Homo sapiens 8-14 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 238-246 mitogen-activated protein kinase 3 Homo sapiens 166-172 17289100-8 2007 Data in the present study suggest that activation of JNK and ERK1/2 may be involved in biphasic effect of arsenite when measuring cell proliferation and apoptosis in HELF cells. arsenite 106-114 mitogen-activated protein kinase 3 Homo sapiens 61-67