PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19622383-0 2009 Coordinated regulation of angiopoietin-1 and vascular endothelial growth factor by arsenite in human brain microvascular pericytes: implications of arsenite-induced vascular dysfunction. arsenite 83-91 vascular endothelial growth factor A Homo sapiens 45-79 22310326-13 2012 Surprisingly, we show that in hepatocytes arsenite decreases expression of two inflammatory mediators, TNF and VEGF, an effect that is not predicted from suppression of RXRalpha activity. arsenite 42-50 vascular endothelial growth factor A Homo sapiens 111-115 21167264-0 2011 Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells. arsenite 101-109 vascular endothelial growth factor A Homo sapiens 81-85 21167264-5 2011 The purpose of the study was to investigate the relationship between the expression of RECK, MMP-9, -2, uPA and VEGF in arsenite-treated human and rat uroepithelial cells. arsenite 120-128 vascular endothelial growth factor A Homo sapiens 112-116 22859221-0 2014 beta-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells. arsenite 28-36 vascular endothelial growth factor A Homo sapiens 45-49 22859221-4 2014 In the present study, we demonstrated that arsenite induced VEGF expression in neuroblastoma SH-SY5Y cells without induction of HIF-1alpha, a well-known transcriptional activator for VEGF suggesting that arsenite-induced VEGF expression in SH-SY5Y cells may not require HIF-1alpha activation. arsenite 43-51 vascular endothelial growth factor A Homo sapiens 60-64 22859221-6 2014 We therefore investigated whether beta-catenin was involved in arsenite-induced VEGF expression in SH-SY5Y cells. arsenite 63-71 vascular endothelial growth factor A Homo sapiens 80-84 22859221-10 2014 These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt. arsenite 58-66 vascular endothelial growth factor A Homo sapiens 75-79 24012885-6 2013 Down-regulation of miR-21 in these cells inhibited the arsenite-induced increases of VEGF levels. arsenite 55-63 vascular endothelial growth factor A Homo sapiens 85-89 23968725-4 2013 Arsenite-induced HIF-1alpha, VEGF and COX-2 expressions were decreased by PI3K inhibitors. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 29-33 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 vascular endothelial growth factor A Homo sapiens 55-59 23968725-7 2013 It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions. arsenite 64-72 vascular endothelial growth factor A Homo sapiens 162-166 23968725-8 2013 In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells. arsenite 15-23 vascular endothelial growth factor A Homo sapiens 39-43 22120617-0 2012 Low arsenite concentrations induce cell proliferation via activation of VEGF signaling in human neuroblastoma SH-SY5Y cells. arsenite 4-12 vascular endothelial growth factor A Homo sapiens 72-76 22120617-5 2012 Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation. arsenite 138-146 vascular endothelial growth factor A Homo sapiens 14-18 22120617-5 2012 Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation. arsenite 138-146 vascular endothelial growth factor A Homo sapiens 65-69 22120617-5 2012 Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation. arsenite 138-146 vascular endothelial growth factor A Homo sapiens 65-69 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 10-18 vascular endothelial growth factor A Homo sapiens 194-198 22120617-6 2012 Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite. arsenite 238-246 vascular endothelial growth factor A Homo sapiens 194-198 21167264-10 2011 However, when the cells were pretreated with inhibitors (5-aza-CdR or U0126) for 24h, the effects of arsenite on RECK, MMP-9, -2, uPA and VEGF expression were suppressed. arsenite 101-109 vascular endothelial growth factor A Homo sapiens 138-142 21167264-12 2011 In in vivo study, our results showed the RECK protein expression was reduced and the expression of MMP-9, -2, uPA and VEGF increased in arsenite treatment groups. arsenite 136-144 vascular endothelial growth factor A Homo sapiens 118-122 21167264-13 2011 In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells. arsenite 51-59 vascular endothelial growth factor A Homo sapiens 121-125 20083128-9 2010 Knock down of HO-1 expression decreased arsenite-induced VEGF expression, cell migration, and tube formation. arsenite 40-48 vascular endothelial growth factor A Homo sapiens 57-61 19622383-5 2009 In this study, we used human brain microvascular pericytes (HBMP) to evaluate the effects of arsenite on Ang-1 and VEGF regulation. arsenite 93-101 vascular endothelial growth factor A Homo sapiens 115-119 19622383-7 2009 Arsenite decreased Ang-1 secretion in a time and dose-dependent manner, while it increased VEGF secretion. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 91-95 19622383-9 2009 Contrary to Ang-1, the expression of VEGF mRNA was dose-dependently up-regulated by arsenite. arsenite 84-92 vascular endothelial growth factor A Homo sapiens 37-41 19622383-10 2009 Treatment with N-actyl-l:-cysteine (NAC) alone decreased the release of Ang-1, but failed to attenuate the arsenite-induced decrease in Ang-1 secretion, while NAC completely blocked the arsenite-stimulated VEGF secretion. arsenite 186-194 vascular endothelial growth factor A Homo sapiens 206-210 19622383-11 2009 These results indicate that reactive oxygen species are involved in the regulation of VEGF, but not of Ang-1, secretion in response to arsenite treatment in pericytes. arsenite 135-143 vascular endothelial growth factor A Homo sapiens 86-90 19622383-13 2009 In conclusion, arsenite decreases Ang-1 secretion and increases VEGF secretion, which may offer new insight into understanding the arsenite toxicity associated with vascular instability and subsequent development of vascular disease. arsenite 15-23 vascular endothelial growth factor A Homo sapiens 64-68 16678800-5 2006 Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied. arsenite 59-67 vascular endothelial growth factor A Homo sapiens 118-122 16678800-5 2006 Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied. arsenite 59-67 vascular endothelial growth factor A Homo sapiens 220-224 14971644-0 2004 Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 32-36 15788408-0 2005 The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. arsenite 23-31 vascular endothelial growth factor A Homo sapiens 42-76 15788408-3 2005 Arsenite, a thiol-reactive oxidative stressor, induces VEGF expression by a HIF-1alpha-independent mechanism. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 55-59 15788408-5 2005 Because ATF4 is expressed in response to oxidative stress, we hypothesized that ATF4 was also responsible for increased VEGF transcription in response to arsenite. arsenite 154-162 vascular endothelial growth factor A Homo sapiens 120-124 15788408-6 2005 We now show that arsenite increased steady state levels of VEGF mRNA and activated transcription from a VEGF promoter construct. arsenite 17-25 vascular endothelial growth factor A Homo sapiens 59-63 15788408-6 2005 We now show that arsenite increased steady state levels of VEGF mRNA and activated transcription from a VEGF promoter construct. arsenite 17-25 vascular endothelial growth factor A Homo sapiens 104-108 15788408-8 2005 Inactivation or loss of ATF4 greatly diminished the VEGF response to arsenite treatment. arsenite 69-77 vascular endothelial growth factor A Homo sapiens 52-56 15788408-10 2005 A complex containing ATF4 binds a DNA element at +1767 bp relative to the VEGF transcription start site, and DNA binding activity is increased by arsenite treatment. arsenite 146-154 vascular endothelial growth factor A Homo sapiens 74-78 15788408-11 2005 In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression. arsenite 92-100 vascular endothelial growth factor A Homo sapiens 104-108 15788408-12 2005 Thus, arsenite-induced up-regulation of VEGF gene transcription occurs by an ATF4-dependent mechanism. arsenite 6-14 vascular endothelial growth factor A Homo sapiens 40-44 14971644-6 2004 Arsenite also increases the expression of VEGF through the induction of HIF-1. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 42-46 14971644-7 2004 We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. arsenite 19-27 vascular endothelial growth factor A Homo sapiens 119-123 14971644-7 2004 We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. arsenite 73-81 vascular endothelial growth factor A Homo sapiens 119-123 14971644-8 2004 The induction of HIF-1 and VEGF by arsenite can not be inhibited by MAP kinase inhibitors. arsenite 35-43 vascular endothelial growth factor A Homo sapiens 27-31 14971644-11 2004 These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. arsenite 29-37 vascular endothelial growth factor A Homo sapiens 111-115 14971644-11 2004 These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. arsenite 185-193 vascular endothelial growth factor A Homo sapiens 111-115 30066004-5 2018 Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha. arsenite 8-16 vascular endothelial growth factor A Homo sapiens 110-114 11641398-0 2001 Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. arsenite 129-137 vascular endothelial growth factor A Homo sapiens 13-47 11641398-2 2001 To investigate whether this is a general phenomenon, we studied the effects of the sulfhydryl reagent arsenite on VEGF expression in human ovarian cancer cells. arsenite 102-110 vascular endothelial growth factor A Homo sapiens 114-118 11641398-4 2001 We report that arsenite induces VEGF mRNA and protein levels in normoxic H134 and OVCAR-3 cells. arsenite 15-23 vascular endothelial growth factor A Homo sapiens 32-36 11641398-5 2001 Arsenite also increases HIF-1alpha protein levels, suggesting a role for HIF-1 in the induction of VEGF expression. arsenite 0-8 vascular endothelial growth factor A Homo sapiens 99-103 11641398-8 2001 These results demonstrate that arsenite-induced VEGF mRNA and HIF-1alpha protein expression is independent of increased ROS production but critically regulated by the cellular reduced glutathione content. arsenite 31-39 vascular endothelial growth factor A Homo sapiens 48-52 33310519-0 2021 microRNA-21, via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate cells. arsenite 71-79 vascular endothelial growth factor A Homo sapiens 32-36 33310519-5 2021 For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells. arsenite 48-56 vascular endothelial growth factor A Homo sapiens 97-131 33310519-5 2021 For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells. arsenite 48-56 vascular endothelial growth factor A Homo sapiens 133-137 33310519-5 2021 For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells. arsenite 208-216 vascular endothelial growth factor A Homo sapiens 97-131 33310519-5 2021 For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells. arsenite 208-216 vascular endothelial growth factor A Homo sapiens 133-137