PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17938202-6 2007 RNA interference targeting c-Jun or ATF4 eliminated arsenite-induced APE1 transcription. arsenite 52-60 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 27-32 15292961-3 2004 In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite. arsenite 226-234 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 67-72 16085347-6 2005 Co-incubation of N-HOS with As and CAPE (0.5-2.5 microM) prevented As-mediated declines in cytokine mRNAs in the co-treated cells, as well as their transformation to anchorage independence, while it caused decreases in c-jun mRNA. arsenite 28-30 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 219-224 15292961-3 2004 In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite. arsenite 226-234 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 174-179 12547826-0 2003 Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. arsenite 15-23 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 94-99 12547826-3 2003 We have shown previously that arsenite can potently activate the mitogen-activated protein kinase cascades and induce the expression of proliferation-associated genes, including proto-oncogenes c-jun and c-fos. arsenite 30-38 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 194-199 12547826-4 2003 In order to elucidate further the molecular mechanisms underlying its tumor-promoting properties, we investigated the signaling events involved in arsenite-mediated induction of c-fos and c-jun. arsenite 147-155 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 188-193 12547826-5 2003 We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation. arsenite 51-59 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 42-47 12547826-6 2003 Interestingly, arsenite dramatically induced the phosphorylation and acetylation of histone H3 preceding the induction of mRNAs encoding c-fos and c-jun. arsenite 15-23 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 147-152 12547826-7 2003 Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway. arsenite 60-68 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 172-177 11055208-14 2000 Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents. arsenite 34-42 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 86-91 12475910-4 2003 In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells. arsenite 65-73 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 211-216 12475910-4 2003 In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells. arsenite 65-73 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 230-234 21726611-0 2011 Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite. arsenite 142-150 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 35-40 27278863-3 2017 Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription. arsenite 90-98 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 230-234 27278863-3 2017 Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription. arsenite 90-98 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 235-240 27278863-3 2017 Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription. arsenite 90-98 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 274-278 23469214-4 2013 RESULTS: MiR-21 was highly expressed in arsenite-transformed HELF cells and normal HELF cells acutely treated with arsenite, an effect that was concomitant with activation of JNK/c-Jun and ERK/NF-kappaB and down-regulation of Pdcd4 and Spry1 protein levels. arsenite 40-48 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 179-184 23469214-7 2013 Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively. arsenite 76-84 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 112-117 23469214-9 2013 CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells. arsenite 209-217 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 10964950-0 2000 Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. arsenite 0-8 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 62-67 23639288-2 2013 Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner. arsenite 46-54 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 125-130 22260869-0 2012 Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. arsenite 0-8 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 97-102 22260869-1 2012 Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels. arsenite 0-8 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 183-188 21726611-6 2011 Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein. arsenite 10-18 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 38-43 21726611-7 2011 Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite. arsenite 302-310 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 21-26 21726611-8 2011 Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite. arsenite 157-165 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 29-34 20566634-0 2010 p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. arsenite 15-23 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 79-84 20566634-5 2010 Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells. arsenite 14-22 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-55 20566634-6 2010 Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression. arsenite 126-134 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 64-69 20566634-7 2010 Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27. arsenite 181-189 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 140-145 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 44-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 96-115 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 44-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 117-121 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 44-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 154-158 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 189-197 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 96-115 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 189-197 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 117-121 19808956-9 2009 Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2. arsenite 189-197 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 154-158 19808956-10 2009 Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells. arsenite 47-55 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 198-202 19808956-10 2009 Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells. arsenite 145-153 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 198-202 19519318-0 2009 PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells. arsenite 55-63 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 19519318-5 2009 The inhibition of JNKs or c-Jun by chemical or genetic inhibitors blocks the cyclin D1 induction mediated by arsenite. arsenite 109-117 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 26-31 19519318-7 2009 Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells. arsenite 93-101 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 53-58