PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21129479-10 2011 The expressions of arsenic-sensitive stress genes, namely metallothionein-1 and heme oxygenase-1, were increased after arsenite or arsenate by 3-10-folds, but were unaltered after LWS and realgar. arsenite 119-127 heme oxygenase 1 Mus musculus 80-96 10473555-5 1999 Under conditions of Nrf2M overexpression, HO-1 mRNA accumulation in response to heme, cadmium, zinc, arsenite, and tert-butylhydroquinone was inhibited by 85-95%. arsenite 101-109 heme oxygenase 1 Mus musculus 42-46 33706700-16 2021 Heme oxygenase-1 (HO-1) gene expression was significantly increased (p < 0.001) in the arsenite-F2 male mice of both groups, but plasma 8-hydroxy-2"-deoxyguanosine (8-OHdG) and cyclooxygenase-2 (COX-2) gene expression were not significantly different. arsenite 87-95 heme oxygenase 1 Mus musculus 0-16 33706700-16 2021 Heme oxygenase-1 (HO-1) gene expression was significantly increased (p < 0.001) in the arsenite-F2 male mice of both groups, but plasma 8-hydroxy-2"-deoxyguanosine (8-OHdG) and cyclooxygenase-2 (COX-2) gene expression were not significantly different. arsenite 87-95 heme oxygenase 1 Mus musculus 18-22 33049506-4 2021 Inconsistent with dampened phosphorylation of immune-related proteins (nuclear factor kappa-B) NF-kappaB, p38 and JNK, the metalloid drastically induced the expression of Heme oxygenase-1 (HO-1) protein, which enlightened us to continuously explore the possible roles of HO-1 pathway in As-induced immune tolerance in BMDCs. arsenite 287-289 heme oxygenase 1 Mus musculus 171-187 33049506-4 2021 Inconsistent with dampened phosphorylation of immune-related proteins (nuclear factor kappa-B) NF-kappaB, p38 and JNK, the metalloid drastically induced the expression of Heme oxygenase-1 (HO-1) protein, which enlightened us to continuously explore the possible roles of HO-1 pathway in As-induced immune tolerance in BMDCs. arsenite 287-289 heme oxygenase 1 Mus musculus 189-193 21321321-9 2011 Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH. arsenite 114-122 heme oxygenase 1 Mus musculus 37-53 18991936-5 2008 Arsenite exposure produced a concentration-dependent induction of heme oxygenase-1 (up to eight-fold) and metallothionein-1 (up to five-fold), indicative of stress response to adapt to arsenic insult. arsenite 0-8 heme oxygenase 1 Mus musculus 66-82 15868481-4 2004 Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha. arsenite 0-8 heme oxygenase 1 Mus musculus 35-38 18404528-0 2008 Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. arsenite 75-83 heme oxygenase 1 Mus musculus 56-60 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. arsenite 58-66 heme oxygenase 1 Mus musculus 0-16 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. arsenite 58-66 heme oxygenase 1 Mus musculus 18-22 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. arsenite 58-66 heme oxygenase 1 Mus musculus 163-167 18404528-2 2008 To further evaluate the role of Nrf2 and its signalling pathway in the induction of HO-1 in response to low levels of arsenite, this paper studied wild-type and Nrf2-deficient murine embryonic fibroblasts. arsenite 118-126 heme oxygenase 1 Mus musculus 84-88 18404528-4 2008 The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1. arsenite 92-100 heme oxygenase 1 Mus musculus 122-126 18404528-4 2008 The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1. arsenite 92-100 heme oxygenase 1 Mus musculus 271-275 12220541-0 2002 Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. arsenite 96-104 heme oxygenase 1 Mus musculus 71-87 12220541-1 2002 The mechanism of heme oxygenase-1 (ho-1) gene activation by arsenite was examined. arsenite 60-68 heme oxygenase 1 Mus musculus 17-33 12220541-1 2002 The mechanism of heme oxygenase-1 (ho-1) gene activation by arsenite was examined. arsenite 60-68 heme oxygenase 1 Mus musculus 35-39 12220541-2 2002 Arsenite-stimulated expression of a ho-1 promoter/luciferase chimera in a dose-dependent manner in mouse hepatoma (Hepa) cells. arsenite 0-8 heme oxygenase 1 Mus musculus 36-40 12220541-8 2002 Together, these results implicate multiple basic-leucine zipper transcription factors in ho-1 gene activation by arsenite. arsenite 113-121 heme oxygenase 1 Mus musculus 89-93