PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28729651-5 2017 Combination of ginsenoside Rb1 and Rd, two major saponin compounds of PNS, recapitulated the retinal protection of PNS and attenuated retinal oxidative stress and inflammatory changes. Ginsenosides 15-26 RB transcriptional corepressor 1 Mus musculus 27-30 30976171-1 2019 Background: The objective of our study was to analyze the neuroprotective effects of ginsenoside derivatives Rb1, Rb2, Rc, Rd, Rg1, and Rg3 against glutamate-mediated neurotoxicity in HT22 hippocampal mouse neuron cells. Ginsenosides 85-96 RB transcriptional corepressor 1 Mus musculus 109-112 28884396-2 2017 Ginsenosides (e.g., Re, Rb1, or Rg1) were obtained from Korean mountain cultivated ginseng. Ginsenosides 0-12 RB transcriptional corepressor 1 Mus musculus 24-27 27640876-4 2017 In the current study, we examined whether ginsenoside Rb1 exerts a cytotoxic effect on mouse embryos at the blastocyst stage, and affects subsequent embryonic development in vitro and in vivo. Ginsenosides 42-53 RB transcriptional corepressor 1 Mus musculus 54-57 18997435-0 2008 Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. Ginsenosides 0-12 RB transcriptional corepressor 1 Mus musculus 13-16 26645822-2 2016 Ginsenoside Rb1 (GS-Rb1) is the most abundant among all the identified ginsenosides and has been shown to exert neuroprotective effects, although the underlying molecular mechanisms remain unclear. Ginsenosides 71-83 RB transcriptional corepressor 1 Mus musculus 12-15 26070903-2 2015 In the present study, we sought to investigate whether and how ginsenoside Rb1 (GS-Rb1), the most abundant ginsenoside, can protect blood-brain barrier (BBB) integrity following cerebral ischemia in middle cerebral artery occlusion (MCAO) animal model. Ginsenosides 63-74 RB transcriptional corepressor 1 Mus musculus 75-78 25912763-3 2015 Ginsenosides Rb1 and Rg1 are primary ingredients of Panax notoginseng for the treatment of cardiovascular diseases, but their impact on AAA is unknown. Ginsenosides 0-12 RB transcriptional corepressor 1 Mus musculus 13-16 25912763-6 2015 Administration of ginsenoside Rb1 (20 mg/kg/day), but not ginsenoside Rg1, significantly reduced the incidence and mortality of AAA. Ginsenosides 18-29 RB transcriptional corepressor 1 Mus musculus 30-33 24558303-1 2014 BACKGROUND: Although ginsenosides such as Rg1, Rb1 and Rg3 have shown promise as potential nutraceuticals for cognitive impairment, their use has been limited due to high production cost and low potency. Ginsenosides 21-33 RB transcriptional corepressor 1 Mus musculus 47-50 23007914-9 2013 Our study reveals a novel mechanism by which ginsenoside promotes hair growth through p63 induction in follicular keratinocytes and indicates that ginsenosides Rb1 and Rd might be developed as a therapeutic agent for the prevention of hair loss. Ginsenosides 45-56 RB transcriptional corepressor 1 Mus musculus 160-163 23007914-9 2013 Our study reveals a novel mechanism by which ginsenoside promotes hair growth through p63 induction in follicular keratinocytes and indicates that ginsenosides Rb1 and Rd might be developed as a therapeutic agent for the prevention of hair loss. Ginsenosides 147-159 RB transcriptional corepressor 1 Mus musculus 160-163 23254888-7 2013 Significant amounts of secondary ginsenosides (F2 and C-K) were found in blood of A/J mice following oral administration of primary ginsenoside Rb1. Ginsenosides 33-45 RB transcriptional corepressor 1 Mus musculus 144-147 22386813-3 2012 In the present study, we determined the effect of ginsenoside Rb1, a major component of ginsenosides, on receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast formation. Ginsenosides 88-100 RB transcriptional corepressor 1 Mus musculus 62-65 22386813-9 2012 Taken together, our data suggest that ginsenoside Rb1 is one of the effective components of GSS for the anti-osteoporosis activity and can inhibit osteoclastogenesis by suppressing RANKL-induced activation of both JNK and p38 MAPKs and NF-kappaB pathways, and consequently down-regulating the gene expression of c-Fos and NFATc1 in osteoclast precursors. Ginsenosides 92-95 RB transcriptional corepressor 1 Mus musculus 50-53 20091796-2 2010 However, recent studies have shown that ginsenosides Rb1, Rg1, and Re exert embryotoxicity in in vitro culture systems. Ginsenosides 40-52 RB transcriptional corepressor 1 Mus musculus 53-56 20091796-8 2010 Major ginsenosides such as Rb1, Rg1, and Re were not detected in the blood of dams based on their chromatographic profiles. Ginsenosides 6-18 RB transcriptional corepressor 1 Mus musculus 27-30 25747994-3 2015 Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively. Ginsenosides 20-31 RB transcriptional corepressor 1 Mus musculus 32-35 23007914-1 2013 Ginsenosides Rb1 and Rd are the two main types of ginsenosides in Panax ginseng and have been used as an additive to against alopecia. Ginsenosides 0-12 RB transcriptional corepressor 1 Mus musculus 13-16 23007914-1 2013 Ginsenosides Rb1 and Rd are the two main types of ginsenosides in Panax ginseng and have been used as an additive to against alopecia. Ginsenosides 50-62 RB transcriptional corepressor 1 Mus musculus 13-16 23007914-6 2013 Results indicated that treatment with ginsenosides Rb1 and Rd increased cell proliferation in both anagen and telogen of HFs. Ginsenosides 38-50 RB transcriptional corepressor 1 Mus musculus 51-54 21740969-8 2011 The increased brain levels of 5-HT induced by Rb1 and E(2) were well described by the present PK-PD model, suggesting the use and further development of this mechanism-based model for the effects of ginsenoside on brain 5-HT levels. Ginsenosides 199-210 RB transcriptional corepressor 1 Mus musculus 46-49 16903076-2 2006 The ginsenoside, Rb1, was tested in order to better understand its potential effects on altering the neurosteroid levels and ultimately attenuating stress. Ginsenosides 4-15 RB transcriptional corepressor 1 Mus musculus 17-20 18409051-1 2008 Several ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) are neuroprotective and antinociceptive agents. Ginsenosides 8-20 RB transcriptional corepressor 1 Mus musculus 22-25 10401990-1 1999 Ginsenoside Rc, Rd, and Re induced antinociception in writhing and formalin tests among five representative ginsenosides: Rb1, Rc, Rd, Re, and Rg1. Ginsenosides 0-11 RB transcriptional corepressor 1 Mus musculus 122-125 19003120-13 1999 Anti-ginsenoside Rb1 MAbs were produced. Ginsenosides 5-16 RB transcriptional corepressor 1 Mus musculus 17-20 19003120-18 1999 Immunostaining of ginsenosides in the fresh ginseng root was succeeded using anti-ginsenoside Rb1 (GRb1) MAb after blotting to PVDF membrane. Ginsenosides 18-30 RB transcriptional corepressor 1 Mus musculus 94-97 19003120-18 1999 Immunostaining of ginsenosides in the fresh ginseng root was succeeded using anti-ginsenoside Rb1 (GRb1) MAb after blotting to PVDF membrane. Ginsenosides 18-29 RB transcriptional corepressor 1 Mus musculus 94-97 10418781-0 1999 Inhibition by ginsenosides Rb1 and Rg1 of cocaine-induced hyperactivity, conditioned place preference, and postsynaptic dopamine receptor supersensitivity in mice. Ginsenosides 14-26 RB transcriptional corepressor 1 Mus musculus 27-30 10909259-12 2000 In summary, ginsenosides Rb1, Rb2, Rc, Rd, and Rg1 administered spinally appear to be responsible for blocking the antinociception induced by U50, 488H administered supraspinally, whereas ginsenosides Rb2 and Re administered supraspinally appear to be responsible for blocking the antinociception induced by U50, 488H administered supraspinally. Ginsenosides 12-24 RB transcriptional corepressor 1 Mus musculus 25-28 34811512-2 2022 In this study we investigated the effects of ginsenoside Rb1 (Rb1), the main active ingredients of Panax notoginseng, in alleviating podocyte injury in diabetic nephropathy and the underlying mechanisms. Ginsenosides 45-56 RB transcriptional corepressor 1 Mus musculus 62-65 9559335-0 1998 Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. Ginsenosides 14-26 RB transcriptional corepressor 1 Mus musculus 27-30 9559335-1 1998 The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine-induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Ginsenosides 4-16 RB transcriptional corepressor 1 Mus musculus 17-20 35600767-2 2022 Previously, we have demonstrated that the ginsenoside Rb1 (Rb1) presents a novel antidepressant-like effect via BDNF-TrkB signaling in the hippocampus of chronic unpredictable mild stress (CUMS)-exposed mice. Ginsenosides 42-53 RB transcriptional corepressor 1 Mus musculus 54-57 35600767-2 2022 Previously, we have demonstrated that the ginsenoside Rb1 (Rb1) presents a novel antidepressant-like effect via BDNF-TrkB signaling in the hippocampus of chronic unpredictable mild stress (CUMS)-exposed mice. Ginsenosides 42-53 RB transcriptional corepressor 1 Mus musculus 59-62 33408776-13 2021 Molecular docking and surface plasmon resonance experiments indicated that ginsenoside Rb1 reduced NADH dehydrogenase activity, probably via binding to the ND3 subunit to trap mitochondrial complex I in a deactive form upon reperfusion. Ginsenosides 75-86 RB transcriptional corepressor 1 Mus musculus 87-90 33604164-10 2021 Results: Both ginsenoside Rb1 and Rb1SalB combination decreased body weight significantly (P < 0.05). Ginsenosides 14-25 RB transcriptional corepressor 1 Mus musculus 26-29 32946961-1 2021 ETHNOPHARMACOLOGICAL RELEVANCE: Recently, a new drug combination GRS comprising ginsenoside Rb1 (G-Rb1), ruscogenin (R-Rus) and schisandrin (S-SA) was screened based on ShengMai preparations, which exhibited a prominent cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury. Ginsenosides 80-91 RB transcriptional corepressor 1 Mus musculus 92-95 33192122-7 2020 Interestingly, KRGE or representative ginsenosides (Rb1, Rg1, and Rg3(s)) inhibited the activity of inflammatory enzymes cyclooxygenase-2 and iNOS, cytosolic p-IkB, and nuclear p-nuclear factor kappa-light-chain-enhancer of activated B in lipopolysaccharide-induced RAW264.7 cells, whereas they increased nuclear factor erythroid-derived 2-related factor 2 nuclear translocation. Ginsenosides 38-50 RB transcriptional corepressor 1 Mus musculus 52-55 33268823-2 2021 Ginsenoside Rb1 (GRb1) is the major ginsenoside in ginseng with multiple pharmacological activities. Ginsenosides 36-47 RB transcriptional corepressor 1 Mus musculus 12-15 32210026-2 2020 Compound K (CK) is produced from the protopanaxadiol (PPD)-type ginsenosides Rb1, Rb2, and Rc by intestinal microbial conversion. Ginsenosides 64-76 RB transcriptional corepressor 1 Mus musculus 77-80 32933639-11 2020 Compared with the low-dose ginsenoside Rb1 group, the aspirin group and the high-dose ginsenoside Rb1 group had significant reductions in the levels of TNF-alpha, IL-6, and IL-1beta (P<0.05); the high-dose ginsenoside Rb1 group had significant increases in the expression levels of P-PI3K/PI3K and P-AKT/AKT (P<0.05). Ginsenosides 86-97 RB transcriptional corepressor 1 Mus musculus 98-101 32933639-11 2020 Compared with the low-dose ginsenoside Rb1 group, the aspirin group and the high-dose ginsenoside Rb1 group had significant reductions in the levels of TNF-alpha, IL-6, and IL-1beta (P<0.05); the high-dose ginsenoside Rb1 group had significant increases in the expression levels of P-PI3K/PI3K and P-AKT/AKT (P<0.05). Ginsenosides 86-97 RB transcriptional corepressor 1 Mus musculus 98-101 32617038-8 2020 The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginsenosides 36-48 RB transcriptional corepressor 1 Mus musculus 15-18 33088689-6 2020 The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides. Ginsenosides 73-85 RB transcriptional corepressor 1 Mus musculus 87-90 31541100-7 2019 The anti-diabetic drug metformin and ginsenoside Rb1 lower blood glucose at least in part by inhibiting p52 activation. Ginsenosides 37-48 RB transcriptional corepressor 1 Mus musculus 49-52 31803965-8 2020 Hydroxysafflor yellow A (HSYA) and Ginsenoside Rb1 are shown to have antioxidant properties, but little is known about their impact in PCOS. Ginsenosides 35-46 RB transcriptional corepressor 1 Mus musculus 47-50 31803965-11 2020 Meanwhile, after HSYA treatment, elevation of serum E2 , P4 , LH and AMH levels as well as reduction of FSH level exhibited the obvious improvement, but Ginsenoside Rb1 only rescued the levels of FSH and AMH. Ginsenosides 153-164 RB transcriptional corepressor 1 Mus musculus 165-168 32933311-2 2020 Here, we aimed to investigate whether ginsenoside Rb1 (Rb1) improves age-related myocardial dysfunction and to identify the relevant molecular mechanism. Ginsenosides 38-49 RB transcriptional corepressor 1 Mus musculus 50-53 32933311-2 2020 Here, we aimed to investigate whether ginsenoside Rb1 (Rb1) improves age-related myocardial dysfunction and to identify the relevant molecular mechanism. Ginsenosides 38-49 RB transcriptional corepressor 1 Mus musculus 55-58 31680950-0 2019 Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor-Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice. Ginsenosides 0-11 RB transcriptional corepressor 1 Mus musculus 12-15 32020864-0 2020 Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-alpha and IL-6 in a cancer cachexia mouse model. Ginsenosides 0-11 RB transcriptional corepressor 1 Mus musculus 12-15 31572200-8 2019 We then explored the antidepressive mechanism of action of the ginsenoside Rb1 (Rb1) related to the brain-derived neurotrophic factor (BDNF) and its downstream proteins in mice exposed to chronic unpredictable mild stress (CUMS). Ginsenosides 63-74 RB transcriptional corepressor 1 Mus musculus 75-78 31572200-8 2019 We then explored the antidepressive mechanism of action of the ginsenoside Rb1 (Rb1) related to the brain-derived neurotrophic factor (BDNF) and its downstream proteins in mice exposed to chronic unpredictable mild stress (CUMS). Ginsenosides 63-74 RB transcriptional corepressor 1 Mus musculus 80-83