PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. Phenylalanine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 31517530-4 2019 Results & conclusions: The binding free energy (DeltaGbind) and the change in the free energy surface (FES) computed from the funnel metadynamics (FMD) simulation, both support the idea that inhibitors (-)-phe and (-)-hex have better binding activities toward enzyme AChE, and that (-)-phe is stronger in binding than the present AD drug (-)-phy. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. Phenylalanine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20347727-4 2010 In addition to well-known residues 288 and 290 (Torpedo AChE sequence numbering), we showed an essential influence of residue 400 - a short alkyl residue in mammalian ChEs and phenylalanine in insect ChEs. Phenylalanine 176-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 16375580-8 2006 In an in vitro study, incubation of Hcy-activated membrane AChE from controls with phenylalanine resulted in restoration of activity, but failed to reverse the stimulated enzyme from hyperhomocysteinaemic MTHFR C677T subjects before therapy. Phenylalanine 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 156-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 156-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 171-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 171-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11926533-7 2002 b) In the hippocampus, inhibition of AChE by Phe could lead to problems in memory, while Na+,K+-ATPase inhibition by Phe may induce metabolic disorders and electrical instability of the synaptosomal membrane. Phenylalanine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 11926533-6 2002 It is suggested that: a) In the frontal cortex, the improper acetylcholine (ACh) release, due to AChE inhibition by Phe, combined with the stimulation of Na+,K+-ATPase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (PKU). Phenylalanine 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 174-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 174-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 189-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 189-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Phenylalanine 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Phenylalanine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-7 2002 Phe negatively correlated with AChE activity and positively with plasma Tyr and DA. Phenylalanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 12498995-8 2002 Ala reversed the inhibited AChE by Phe in erythrocyte membranes from healthy children to control values, whereas no reverse effect was observed on the enzyme activity from PKU patients. Phenylalanine 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 12498995-10 2002 So, high Phe blood levels inhibit AChE in PKU patients, probably resulting in higher acetylcholine concentrations. Phenylalanine 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12498995-11 2002 b) Determination of AChE in erythrocyte membranes from PKU could be a useful marker for the neurotoxic effects of Phe. Phenylalanine 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 187-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 204-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 243-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-2 2002 AChE activity was determined in brain homogenates and in the pure enzyme after 1 h preincubation with 1.2 mM of Phe or Ala as well as with Phe plus Ala. Phenylalanine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12132693-4 2002 Ala reversed completely the inhibited AChE by Phe (18-20% in 500-600 microM substrate, p<0.01). Phenylalanine 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 197-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 9618943-0 1998 In vitro influence of phenylalanine on acetylcholinesterase activity and DNA. Phenylalanine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 9618943-3 1998 AChE activity was measured spectrophotometrically after incubation with various Phe concentrations. Phenylalanine 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9618943-5 1998 Phe was found to inhibit AChE almost 40%, at a concentration of 5 mM, whereas a 62.5% DNA peak exclusion (molecular interaction) was observed when Phe was incubated with DNA at a concentration of 3 mM. Phenylalanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29