PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30176570-4	2018	Particularly, the new dipeptide-sulfonamide conjugates incorporating Ala, Phe and Met in the dipeptide sequence, showed the most effective inhibitory activity against to CA IX and XII.	Phenylalanine	74-77	carbonic anhydrase 9	Homo sapiens	170-175	
32570870-6	2020	We also review the accumulating evidence that suggest a role for CAIX as a biological pH-stat by which solid tumours stabilize their pHe.	Phenylalanine	133-136	carbonic anhydrase 9	Homo sapiens	65-69	
30362386-7	2019	The cytotoxic effect occurred via apoptosis, being accompanied by a return of pHe/pHi towards normal values as for other CA IX inhibitors investigated earlier.	Phenylalanine	78-81	carbonic anhydrase 9	Homo sapiens	121-126	
30272043-4	2015	CA IX helps to maintain normal cytoplasmic pH (pHi) while simultaneously contributing to the extracellular pH (pHe).	Phenylalanine	111-114	carbonic anhydrase 9	Homo sapiens	0-5	
26864256-4	2016	This results in the generation of a pH gradient between the low extracellular pH that is acidic (pHe) and the higher cytosolic alkaline or near neutral pH (pHi) environments that are tightly regulated by the overexpression of several pumps and ion channels (e.g. NHE-1, MCT-1, V-ATPase, CA9, and CA12).	Phenylalanine	97-100	carbonic anhydrase 9	Homo sapiens	287-290	
19861127-5	2009	Moreover, they abolish the CA IX capacity to acidify extracellular pH (pHe) and bind CA IX-selective sulfonamide inhibitor in hypoxia.	Phenylalanine	71-74	carbonic anhydrase 9	Homo sapiens	27-32	
16098620-6	2005	RESULTS: Under normal pHe conditions, CA9, GLUT1 and LDHA gene expression was upregulated within 1-3h of anoxia, reaching near maximal values by 6h.	Phenylalanine	22-25	carbonic anhydrase 9	Homo sapiens	38-41	
16098620-11	2005	Expression of CA9, GLUT1, OPN and LDHA was inhibited under hypoxic conditions when pHe was reduced to 6.3.	Phenylalanine	83-86	carbonic anhydrase 9	Homo sapiens	14-17	
15556624-5	2004	This study provides the first evidence for the role of CA IX in the control of pHe.	Phenylalanine	79-82	carbonic anhydrase 9	Homo sapiens	55-60