PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2509067-0 1989 Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Benzo(a)pyrene 75-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-42 3697359-5 1986 Differences in the conformational change were observed between the two enzymes, and the conformational change of cytochrome P-450 II-d using benzo[a]pyrene as a substrate was different from that using 7-ethoxycoumarin. Benzo(a)pyrene 141-155 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 113-129 2512389-1 1989 The involvement of cytochrome P-450 isozymes in the activation of benzo[a]pyrene (BP) by human placental and liver microsomes was studied in vitro using monoclonal antibodies (Mab) toward the major 3-methylcholanthrene (MC)-inducible and phenobarbital-inductible rat liver P-450 isozymes (Mab 1-7-1 and Mab 2-66-3, respectively). Benzo(a)pyrene 66-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-35 2512389-1 1989 The involvement of cytochrome P-450 isozymes in the activation of benzo[a]pyrene (BP) by human placental and liver microsomes was studied in vitro using monoclonal antibodies (Mab) toward the major 3-methylcholanthrene (MC)-inducible and phenobarbital-inductible rat liver P-450 isozymes (Mab 1-7-1 and Mab 2-66-3, respectively). Benzo(a)pyrene 82-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-35 2882985-3 1987 It appears that the high affinity enzyme is a polycyclic aromatic hydrocarbon-inducible isozyme of cytochrome P-450, based on competitive inhibition by 7-ethoxyresorufin and benzo[a]pyrene, and based on a significant (p less than 0.001) correlation between 7-ethoxyresorufin-O-deethylation and methylxanthine demethylation rates. Benzo(a)pyrene 174-188 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 99-115 3697359-6 1986 The results suggest that the substrate-binding sites of the two enzymes differ in position toward the heme, and that there are at least two different substrate sites in cytochrome P-450 II-d, one for benzo[a]pyrene and another for 7-ethoxycoumarin. Benzo(a)pyrene 200-214 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 169-185 6477826-1 1984 Arylhydrocarbon-hydroxylase (AHH) is a cytochrome P-450-dependent polysubstrate mono-oxygenase which plays an important role in converting some compounds (e.g. benzo[a]pyrene) to highly reactive carcinogenic species. Benzo(a)pyrene 160-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-55 6088105-9 1984 These results demonstrate that oxidation products of the peroxidation of lipids and fatty acids are able to react directly with benzo[a]pyrene to form products including benzo[a]pyrene quinones without the presence of enzymes such as the cytochrome P-450 mixed function oxidase system and prostaglandin synthetase. Benzo(a)pyrene 128-142 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 238-254 6626210-1 1983 The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH. Benzo(a)pyrene 153-167 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 81-97 6626210-5 1983 These findings together with the results obtained with flavone on the metabolism of benzo(a)pyrene by various microsomal preparations suggest a parallel induction of multiple forms of cytochrome P-450 as observed in mammalian liver under identical condition. Benzo(a)pyrene 84-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 184-200 31111189-3 2019 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene 49-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-176 6105054-0 1980 Correlations between cytochrome P-450 and oxidative metabolism of benzo[a]pyrene and 7-ethoxycoumarin in human liver in vitro and antipyrine elimination in vivo. Benzo(a)pyrene 66-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-37 719999-8 1978 Study in vitro of the kinetics of two reactions, namely aminopyrine N-demethylation and 3,4-benzpyrene hydroxylation, catalysed by the hepatic microsomal cytochrom P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450 with different catalytic properties from those of forms induced by either phenobarbital or 3-methylcholanthrene. Benzo(a)pyrene 88-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 246-262 719999-8 1978 Study in vitro of the kinetics of two reactions, namely aminopyrine N-demethylation and 3,4-benzpyrene hydroxylation, catalysed by the hepatic microsomal cytochrom P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450-dependent enzyme system, suggested that hexachlorobenzene induced a form of cytochrome P-450 with different catalytic properties from those of forms induced by either phenobarbital or 3-methylcholanthrene. Benzo(a)pyrene 88-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 339-355 6285672-0 1982 Interindividual variation in benzo(a)pyrene metabolism and composition of isoenzymes of cytochrome P-450 as revealed by SDS-gel electrophoresis of human liver microsomal fractions. Benzo(a)pyrene 29-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 88-104 31111189-3 2019 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene 49-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 178-181 31111189-3 2019 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene 65-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-176 31111189-3 2019 Treatment of human keratinocytes with 2.5 microM benzo[a]pyrene (BaP), a tobacco smoke constituent and aryl hydrocarbon receptor (AHR) agonist, for 24 h induced cytochrome P450 (CYP) 1A enzyme activity. Benzo(a)pyrene 65-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 178-181 29921510-0 2018 The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells. Benzo(a)pyrene 45-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-67 28701518-4 2017 Studies in animal models suggest that changes in the production of cytochrome P450 eicosanoids alter BP. Benzo(a)pyrene 101-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-82 20399842-2 2010 BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1. Benzo(a)pyrene 0-2 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-118 24372170-2 2014 However, while in eukaryotes, the cytochrome P450 (CYP)-mediated activation of benzo[a]pyrene (B[a]P) has become a model for metabolism-mediated carcinogenesis, the oxidative degradation of B[a]P by microorganisms is less well studied. Benzo(a)pyrene 79-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-49 24372170-2 2014 However, while in eukaryotes, the cytochrome P450 (CYP)-mediated activation of benzo[a]pyrene (B[a]P) has become a model for metabolism-mediated carcinogenesis, the oxidative degradation of B[a]P by microorganisms is less well studied. Benzo(a)pyrene 79-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-54 22155354-4 2012 The AhR has particular importance in the lung and is most commonly associated with the up-regulation of cytochrome P-450 (CYP)-mediated metabolism of benzo[a]pyrene (B[a]P) to reactive intermediates. Benzo(a)pyrene 150-164 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-120 22155354-4 2012 The AhR has particular importance in the lung and is most commonly associated with the up-regulation of cytochrome P-450 (CYP)-mediated metabolism of benzo[a]pyrene (B[a]P) to reactive intermediates. Benzo(a)pyrene 150-164 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 122-125 20399842-2 2010 BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1. Benzo(a)pyrene 0-2 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 120-123 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 33-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-66 21783461-0 2005 Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Benzo(a)pyrene 39-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-85 21783461-8 2005 BaP itself exhibited estrogenicity in the ER-CALUX assay due to bio-activation into estrogenic metabolites, probably via aryl hydrocarbon receptor (AhR) induced CYP activity. Benzo(a)pyrene 0-3 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-164 17967930-12 2008 Cytochrome P450 inducers enhanced the conversion of benzo[a]pyrene to these metabolites without altering mRNA levels of major phenol-conjugating SULT forms (SULT1A1, SULT1A3, and SULT1B1). Benzo(a)pyrene 52-66 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17237483-1 2007 Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases. Benzo(a)pyrene 25-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 202-217 17237483-1 2007 Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases. Benzo(a)pyrene 25-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 219-222 17237483-1 2007 Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases. Benzo(a)pyrene 41-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 202-217 17237483-1 2007 Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) mixed function oxidases. Benzo(a)pyrene 41-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 219-222 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 140-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-66 8507205-0 1993 The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Benzo(a)pyrene 72-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-62 12227954-6 2002 Skin preexposure to the skin CYP450 inducer BaP largely changed label penetration depth and distribution pattern in cutaneous tissues and decreased (14)C concentration in skin and fat. Benzo(a)pyrene 44-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 29-35