PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21633290-4	2011	On the contrary, the enzyme activity of cox-2 showed a significant increase in the BP-treated mice.	Benzo(a)pyrene	83-85	prostaglandin-endoperoxide synthase 2	Mus musculus	40-45	
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	prostaglandin-endoperoxide synthase 2	Mus musculus	192-208	
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	prostaglandin-endoperoxide synthase 2	Mus musculus	210-215	
12087061-1	2002	The developmental role of prostaglandin H synthase-2 (PHS-2), which converts xenobiotics such as benzo[a]pyrene (B[a]P) to toxic free radical intermediates, is poorly understood.	Benzo(a)pyrene	97-111	prostaglandin-endoperoxide synthase 2	Mus musculus	26-52	
12087061-1	2002	The developmental role of prostaglandin H synthase-2 (PHS-2), which converts xenobiotics such as benzo[a]pyrene (B[a]P) to toxic free radical intermediates, is poorly understood.	Benzo(a)pyrene	97-111	prostaglandin-endoperoxide synthase 2	Mus musculus	54-59	
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117	
35065163-10	2022	Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP.	Benzo(a)pyrene	121-124	prostaglandin-endoperoxide synthase 2	Mus musculus	50-55	
27608907-9	2016	Moreover, BP treatment brought about a significant increase in the activity of COX-2.	Benzo(a)pyrene	10-12	prostaglandin-endoperoxide synthase 2	Mus musculus	79-84	
21633290-6	2011	In contrast, synergistic supplementation with phytochemicals resulted in a significant decrease in the enzyme activities of cox-2 in BP-treated mice.	Benzo(a)pyrene	133-135	prostaglandin-endoperoxide synthase 2	Mus musculus	124-129