PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25638374-1	2014	OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	186-189	epoxide hydrolase 1	Homo sapiens	212-240	
16963132-6	2006	Like trout CYP1A1, cDNA-expressed zCYP1A was found to oxidize BaP to phenols, quinones and diols (BaP-7,8-diol and BaP-9,10-diol) in the presence of exogenous human microsomal epoxide hydrolase (hEH).	Benzo(a)pyrene	62-65	epoxide hydrolase 1	Homo sapiens	165-193	
24362093-1	2013	OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH).	Benzo(a)pyrene	121-135	epoxide hydrolase 1	Homo sapiens	163-191	
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	epoxide hydrolase 1	Homo sapiens	48-76	
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	epoxide hydrolase 1	Homo sapiens	48-76	
15256148-1	2004	OBJECTIVE: To explore the relationship between genetic polymorphisms of microsomal epoxide hydrolase (mEH) and susceptibility of chronic benzene poisoning (BP).	Benzo(a)pyrene	156-158	epoxide hydrolase 1	Homo sapiens	72-100	
11597790-1	2001	Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE).	Benzo(a)pyrene	90-104	epoxide hydrolase 1	Homo sapiens	6-34	
9014198-1	1996	The metabolism of benzo[a]pyrene (B[a]P) and its proximate mutagen B[a]P-7,8-dihydrodiol (7,8-diol) was investigated in the presence of human microsomal epoxide hydrolase and P450 1A1, 1A2, 2C8, 2C9, 2C18, 2C19, 2D6 and 3A4 expressed in the yeast Saccharomyces cerevisiae.	Benzo(a)pyrene	18-32	epoxide hydrolase 1	Homo sapiens	142-170	
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	28-42	epoxide hydrolase 1	Homo sapiens	181-209	
34360828-1	2021	The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase.	Benzo(a)pyrene	44-47	epoxide hydrolase 1	Homo sapiens	181-209