PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32557721-8	2020	Results indicated that pre-treatment with BaP increased expression of IL-8 in house dust mite-activated EOL-1, BEAS-2B, and A549 cells.	Benzo(a)pyrene	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
31135098-6	2020	We also assessed the production of inflammatory factors interleukin-8 and chemokine ligand-2 induced by benzo(a)pyrene exposure at both mRNA and protein levels.	Benzo(a)pyrene	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	56-69	
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	99-103	
28238931-0	2017	Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells.	Benzo(a)pyrene	32-46	C-X-C motif chemokine ligand 8	Homo sapiens	10-28	
28238931-9	2017	These findings suggest that IL-8 increased the formation of B[a]P-7,8-diol despite an overall delayed B[a]P metabolism via depletion of GSH, but DNA damage levels were unaffected due to an increase in NER capacity.	Benzo(a)pyrene	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	28-32	
31323583-7	2019	We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control.	Benzo(a)pyrene	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	126-130	
25174381-18	2014	Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01).	Benzo(a)pyrene	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	82-86	
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	99-103	
21316925-0	2011	An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	80-93	
21675704-4	2011	Exposure of BEAS-2B and HBE to BaP caused epithelial cells to produce inflammatory cytokines IL-8, which subsequently induced BSMC proliferation and migration.	Benzo(a)pyrene	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	93-97	
18289803-0	2008	Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.	Benzo(a)pyrene	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	0-13	
18289803-3	2008	In primary human macrophages, BP was shown to induce IL-8 expression at both mRNA and secretion levels in a dose-dependent manner.	Benzo(a)pyrene	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
18289803-8	2008	Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical.	Benzo(a)pyrene	81-83	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	104-108	
18289803-5	2008	Moreover, electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation experiments showed BP-triggered binding of AhR to a consensus xenobiotic responsive element (XRE) found in the human IL-8 promoter.	Benzo(a)pyrene	109-111	C-X-C motif chemokine ligand 8	Homo sapiens	207-211	
17886062-10	2007	BaP and Phe significantly enhanced cytokine secretion (IL-4, IL-8) and histamine release from purified basophils without antigen added, and secretion was not further enhanced by rBet v 1 stimulation.	Benzo(a)pyrene	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	128-132	
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	128-132