PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25724555-10	2015	These data demonstrate that iRoot BP Plus can promote DPC migration and pulp repair involving the FGFR-mediated ERK 1/2, JNK, and Akt pathways.	Benzo(a)pyrene	34-36	mitogen-activated protein kinase 8	Homo sapiens	121-124	
26359795-0	2016	Benzo(a)pyrene inhibits migration and invasion of extravillous trophoblast HTR-8/SVneo cells via activation of the ERK and JNK pathway.	Benzo(a)pyrene	0-14	mitogen-activated protein kinase 8	Homo sapiens	123-126	
21911080-8	2011	In addition, after BaP treatment, c-Jun N-terminal kinase (JNK) and Bax were activated during apoptosis and no change in p73 protein level was observed.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase 8	Homo sapiens	34-57	
25655200-8	2015	BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs.	Benzo(a)pyrene	0-2	mitogen-activated protein kinase 8	Homo sapiens	63-66	
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	mitogen-activated protein kinase 8	Homo sapiens	135-138	
23994263-11	2014	Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1.	Benzo(a)pyrene	44-47	mitogen-activated protein kinase 8	Homo sapiens	145-148	
21911080-8	2011	In addition, after BaP treatment, c-Jun N-terminal kinase (JNK) and Bax were activated during apoptosis and no change in p73 protein level was observed.	Benzo(a)pyrene	19-22	mitogen-activated protein kinase 8	Homo sapiens	59-62	
21911080-10	2011	Activation of JNK and Bax possibly contributed to BaP-induced apoptosis.	Benzo(a)pyrene	50-53	mitogen-activated protein kinase 8	Homo sapiens	14-17	
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	35-49	mitogen-activated protein kinase 8	Homo sapiens	171-177	
17959047-1	2007	OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions.	Benzo(a)pyrene	51-54	mitogen-activated protein kinase 8	Homo sapiens	171-177	
17959047-8	2007	CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations.	Benzo(a)pyrene	65-68	mitogen-activated protein kinase 8	Homo sapiens	20-26	
16041517-0	2005	Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals.	Benzo(a)pyrene	33-47	mitogen-activated protein kinase 8	Homo sapiens	108-112	
16600107-11	2006	CONCLUSION: ERK and JNK, but not p38, mediated benzo(a)pyrene-induced cell cycle changes by AP-1 transactivation in HELF.	Benzo(a)pyrene	47-61	mitogen-activated protein kinase 8	Homo sapiens	20-23	
11564864-0	2001	Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.	Benzo(a)pyrene	131-145	mitogen-activated protein kinase 8	Homo sapiens	65-94