PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33324084-7 2020 A significant drop was observed in BaP-induced tumor marker enzymes (ADA, AHH, gamma-GT, LDH) in the serum of the mice treated with DAS. Benzo(a)pyrene 35-38 aryl-hydrocarbon receptor Mus musculus 74-77 6090886-2 1984 Mouse liver cytosol contains saturable, high-affinity binding sites for the aromatic carcinogen benzo[a]pyrene that are distinct from the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding aryl hydrocarbon receptor. Benzo(a)pyrene 96-110 aryl-hydrocarbon receptor Mus musculus 189-214 288335-1 1979 The influence of microsomal (mAHH) and nuclear (nAHH) aryl hydrocarbon hydroxylase activity on the covalent binding of tritiated benzo(a)pyrene to rat liver DNA was evaluated in vivo. Benzo(a)pyrene 129-143 aryl-hydrocarbon receptor Mus musculus 29-33 6322977-0 1984 Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols. Benzo(a)pyrene 11-25 aryl-hydrocarbon receptor Mus musculus 59-70 33977171-0 2021 Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 75-100 32808713-1 2020 Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 112-137 32808713-1 2020 Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 139-142 32808713-1 2020 Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 112-137 32808713-1 2020 Benzo[a]pyrene (B[a]P), a potent carcinogen, has been proved that it can induce apoptosis via activation of the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 139-142 30165701-6 2018 Interestingly, the AhR antagonist resveratrol, attenuated BaP-induced mitochondrial respiratory defects in the pancreas, and reversed pancreatitis, both histologically and biochemically in wild-type mice. Benzo(a)pyrene 58-61 aryl-hydrocarbon receptor Mus musculus 19-22 32557721-0 2020 Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation. Benzo(a)pyrene 43-57 aryl-hydrocarbon receptor Mus musculus 14-39 32557721-1 2020 We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis. Benzo(a)pyrene 30-44 aryl-hydrocarbon receptor Mus musculus 56-81 32557721-1 2020 We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis. Benzo(a)pyrene 30-44 aryl-hydrocarbon receptor Mus musculus 83-86 32557721-1 2020 We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis. Benzo(a)pyrene 46-49 aryl-hydrocarbon receptor Mus musculus 56-81 32557721-1 2020 We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis. Benzo(a)pyrene 46-49 aryl-hydrocarbon receptor Mus musculus 83-86 32557721-2 2020 The present study aimed to determine whether BaP-induced AhR activation results in development of airway inflammation. Benzo(a)pyrene 45-48 aryl-hydrocarbon receptor Mus musculus 57-60 31811747-3 2020 The ligands of AhR such as tetrachlorodibenzo-p-dioxin, benzo[a]pyrene and 3, 3"-diindolylmetheane are able to inhibit osteoclastogenesis and attenuate arthritis in mice. Benzo(a)pyrene 56-70 aryl-hydrocarbon receptor Mus musculus 15-18 30982974-0 2019 Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 106-131 30982974-6 2019 The role of aryl hydrocarbon receptor (AhR) signaling in BaP-promoted Der f 1-induced ROS, cytokine production, and allergic inflammation was also investigated. Benzo(a)pyrene 57-60 aryl-hydrocarbon receptor Mus musculus 39-42 30982974-9 2019 Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression. Benzo(a)pyrene 10-13 aryl-hydrocarbon receptor Mus musculus 49-52 30982974-9 2019 Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression. Benzo(a)pyrene 10-13 aryl-hydrocarbon receptor Mus musculus 92-95 30982974-12 2019 Finally, AhR antagonist CH223191 and NAC inhibited BaP co-exposure with Der f 1-induced lung inflammation. Benzo(a)pyrene 51-54 aryl-hydrocarbon receptor Mus musculus 9-12 31086989-1 2019 Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified. Benzo(a)pyrene 117-131 aryl-hydrocarbon receptor Mus musculus 195-220 31086989-1 2019 Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified. Benzo(a)pyrene 117-131 aryl-hydrocarbon receptor Mus musculus 222-225 32684523-0 2020 Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 97-100 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 158-183 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 185-188 32417428-6 2020 Compared to BaP, exposure to COR resulted in less activation of the aryl hydrocarbon receptor (AhR) and thus less induction of hepatic cytochrome P450 1a (Cyp1a) enzymes, which play a critical role in metabolism of both COR and BaP. Benzo(a)pyrene 12-15 aryl-hydrocarbon receptor Mus musculus 68-93 32062438-17 2020 Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis. Benzo(a)pyrene 46-49 aryl-hydrocarbon receptor Mus musculus 165-190 32062438-17 2020 Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis. Benzo(a)pyrene 46-49 aryl-hydrocarbon receptor Mus musculus 192-195 31660294-9 2019 The results revealed that the oral administration of benzo(a)pyrene resulted in increases in relative lung weight, serum levels of tumor markers (ADA, AHH, and LDH), and the inflammatory marker NF-kappaB, and a decreased total antioxidant capacity compared with the control. Benzo(a)pyrene 53-67 aryl-hydrocarbon receptor Mus musculus 151-154 30982974-13 2019 CONCLUSIONS: Our findings suggest that BaP facilitates Der f 1-induced epithelial cytokine release through the AhR-ROS axis. Benzo(a)pyrene 39-42 aryl-hydrocarbon receptor Mus musculus 111-114 30748024-0 2019 Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T-helper 2-driven proinflammatory responses in a mouse model of allergic dermatitis. Benzo(a)pyrene 50-64 aryl-hydrocarbon receptor Mus musculus 21-46 30165701-9 2018 Resveratrol, a chemo preventive agent and AhR antagonist, and CH-223191, a potent and specific AhR inhibitor, confer protection against BaP-induced mitochondrial dysfunction and pancreatic pathology. Benzo(a)pyrene 136-139 aryl-hydrocarbon receptor Mus musculus 95-98 30099064-0 2018 Aryl hydrocarbon receptor activation by benzo(a)pyrene inhibits proliferation of myeloid precursor cells and alters the differentiation state as well as the functional phenotype of murine bone marrow-derived macrophages. Benzo(a)pyrene 40-54 aryl-hydrocarbon receptor Mus musculus 0-25 30053493-0 2018 Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 150-175 30053493-2 2018 Most effects of BaP towards immune cells are thought to be mediated through activation of the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 94-119 30053493-2 2018 Most effects of BaP towards immune cells are thought to be mediated through activation of the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 121-124 30099064-3 2018 Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected. Benzo(a)pyrene 80-94 aryl-hydrocarbon receptor Mus musculus 40-43 30099064-3 2018 Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected. Benzo(a)pyrene 80-94 aryl-hydrocarbon receptor Mus musculus 69-72 30099064-3 2018 Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected. Benzo(a)pyrene 96-99 aryl-hydrocarbon receptor Mus musculus 40-43 30099064-3 2018 Our results show that the activation of AhR by subtoxic doses of the AhR ligand benzo(a)pyrene (BaP) impaired the proliferation of bone marrow cells (BMCs) whereas the proportion of resulting adherent cells was not affected. Benzo(a)pyrene 96-99 aryl-hydrocarbon receptor Mus musculus 69-72 30099064-5 2018 However, expression of the murine macrophage marker F4/80, the major histocompatibility complex class II (MHC-II) and the Fcgamma receptor I (FcgammaRI/CD64) were upregulated on BaP-exposed BMMs in an AhR-dependent manner. Benzo(a)pyrene 178-181 aryl-hydrocarbon receptor Mus musculus 201-204 28007926-7 2017 The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands. Benzo(a)pyrene 91-94 aryl-hydrocarbon receptor Mus musculus 32-57 27293999-0 2016 The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta1 signaling: implications in hepatocellular carcinogenesis. Benzo(a)pyrene 38-52 aryl-hydrocarbon receptor Mus musculus 4-29 27849171-6 2016 Furthermore, ligand activation of AhR by the smoke toxin benzo[a]pyrene accelerated osteoclast differentiation in a receptor-dependent manner, and AhR-dependent regulation of mitochondrial biogenesis in osteoclasts was observed. Benzo(a)pyrene 57-71 aryl-hydrocarbon receptor Mus musculus 34-37 28116098-10 2016 This AhR-dependent progenitor recovery with BP induction accounts for the absence of suppression of B220+ BM and spleen populations at 48-168 h. However, DMBA and BP produced similar profiles for thymus cell suppression, independent of AhR genotype. Benzo(a)pyrene 44-46 aryl-hydrocarbon receptor Mus musculus 5-8 25178717-7 2014 Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR(+/+) fibroblasts concomitant with decreased AhR protein levels. Benzo(a)pyrene 25-39 aryl-hydrocarbon receptor Mus musculus 12-15 26215100-4 2015 A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. Benzo(a)pyrene 136-150 aryl-hydrocarbon receptor Mus musculus 38-41 26215100-4 2015 A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. Benzo(a)pyrene 136-150 aryl-hydrocarbon receptor Mus musculus 91-94 26215100-4 2015 A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. Benzo(a)pyrene 136-150 aryl-hydrocarbon receptor Mus musculus 91-94 25233930-2 2014 We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Benzo(a)pyrene 237-251 aryl-hydrocarbon receptor Mus musculus 151-176 25233930-2 2014 We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Benzo(a)pyrene 253-256 aryl-hydrocarbon receptor Mus musculus 151-176 23800876-5 2013 Induction also required Nrf2, as induction by benzo[a]pyrene was lost in the liver of Nrf2 knockout mice similarly to induction by butyl hydroxyanisol, demonstrating a cross-interaction between the AhR and Nrf2 pathways for induction in vivo. Benzo(a)pyrene 46-60 aryl-hydrocarbon receptor Mus musculus 198-201 23776235-2 2013 Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes. Benzo(a)pyrene 36-50 aryl-hydrocarbon receptor Mus musculus 122-147 23776235-2 2013 Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes. Benzo(a)pyrene 36-50 aryl-hydrocarbon receptor Mus musculus 149-152 23776235-2 2013 Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes. Benzo(a)pyrene 52-55 aryl-hydrocarbon receptor Mus musculus 122-147 23776235-2 2013 Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes. Benzo(a)pyrene 52-55 aryl-hydrocarbon receptor Mus musculus 149-152 21567390-0 2012 Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene. Benzo(a)pyrene 108-122 aryl-hydrocarbon receptor Mus musculus 0-25 22561122-1 2012 Most studies about functions of aryl hydrocarbon receptor (AhR) in the pathogenesis of asthma have been carried out with non-physiological industrial by-products such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene. Benzo(a)pyrene 210-224 aryl-hydrocarbon receptor Mus musculus 32-57 22561122-1 2012 Most studies about functions of aryl hydrocarbon receptor (AhR) in the pathogenesis of asthma have been carried out with non-physiological industrial by-products such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene. Benzo(a)pyrene 210-224 aryl-hydrocarbon receptor Mus musculus 59-62 22228805-6 2012 Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 96-99 22228805-6 2012 Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 141-144 22228805-6 2012 Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation. Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 96-99 22228805-6 2012 Benzo[a]pyrene (BaP), a pervasive environmental toxicant, atherogen, and potent agonist for the AHR, was used as the environmental agent for AHR activation. Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 141-144 22228805-7 2012 We tested the hypothesis that activation of the AHR of different signaling potencies by BaP would have differential effects on the physiology and pathology of the mouse cardiovascular system. Benzo(a)pyrene 88-91 aryl-hydrocarbon receptor Mus musculus 48-51 22228805-8 2012 We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta. Benzo(a)pyrene 61-64 aryl-hydrocarbon receptor Mus musculus 27-30 22228805-8 2012 We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta. Benzo(a)pyrene 61-64 aryl-hydrocarbon receptor Mus musculus 112-115 22228805-8 2012 We found that differential AHR signaling from an exposure to BaP caused lethality in mice with the low-affinity AHR, altered the growth rates of the body and several organs, induced atherosclerosis to a greater extent in mice with the high-affinity AHR, and had a huge impact on gene expression of the aorta. Benzo(a)pyrene 61-64 aryl-hydrocarbon receptor Mus musculus 112-115 22486318-7 2012 Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs. Benzo(a)pyrene 11-25 aryl-hydrocarbon receptor Mus musculus 49-52 22486318-7 2012 Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs. Benzo(a)pyrene 27-30 aryl-hydrocarbon receptor Mus musculus 49-52 21567390-8 2012 Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent. Benzo(a)pyrene 78-81 aryl-hydrocarbon receptor Mus musculus 12-15 21567390-8 2012 Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent. Benzo(a)pyrene 78-81 aryl-hydrocarbon receptor Mus musculus 35-38 21567390-8 2012 Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR-independent. Benzo(a)pyrene 78-81 aryl-hydrocarbon receptor Mus musculus 35-38 21252291-0 2011 Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes. Benzo(a)pyrene 49-63 aryl-hydrocarbon receptor Mus musculus 91-116 21803694-2 2011 OBJECTIVES: We conducted studies to evaluate the role of AHR polymorphisms in the disruption of renal developmental programming by benzo(a)pyrene (BaP). Benzo(a)pyrene 131-145 aryl-hydrocarbon receptor Mus musculus 57-60 21803694-2 2011 OBJECTIVES: We conducted studies to evaluate the role of AHR polymorphisms in the disruption of renal developmental programming by benzo(a)pyrene (BaP). Benzo(a)pyrene 147-150 aryl-hydrocarbon receptor Mus musculus 57-60 21569818-1 2011 Exposure to the environmental mutagen benzo(a)pyrene (BaP) alters the expression of AHR-responsive genes as well as genes involved in other pathways. Benzo(a)pyrene 38-52 aryl-hydrocarbon receptor Mus musculus 84-87 21569818-1 2011 Exposure to the environmental mutagen benzo(a)pyrene (BaP) alters the expression of AHR-responsive genes as well as genes involved in other pathways. Benzo(a)pyrene 54-57 aryl-hydrocarbon receptor Mus musculus 84-87 21569840-10 2011 Knockdown of AhR by RNA interference diminished BaP-induced expression of Nrf2 and NQO1. Benzo(a)pyrene 48-51 aryl-hydrocarbon receptor Mus musculus 13-16 21569840-14 2011 These results suggest that catalase overexpression upregulates BaP-induced NQO1 expression by enhancing the Sp1-AhR-Nrf2 signaling cascade. Benzo(a)pyrene 63-66 aryl-hydrocarbon receptor Mus musculus 112-115 21252291-7 2011 AhR, therefore, mediates this BP recovery in each progenitor type. Benzo(a)pyrene 30-32 aryl-hydrocarbon receptor Mus musculus 0-3 20570689-5 2010 Induction by 3MC and BaP was AHR dependent but, surprisingly, the potent AHR agonist, TCDD, did not induce FMO3 mRNA in Hepa-1 cells nor did chromatin immunoprecipitation assays detect recruitment of AHR or ARNT to Fmo3 regulatory elements after exposure to 3MC in liver or in Hepa-1 cells. Benzo(a)pyrene 21-24 aryl-hydrocarbon receptor Mus musculus 29-32 21177068-5 2011 We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo. Benzo(a)pyrene 78-83 aryl-hydrocarbon receptor Mus musculus 92-117 21177068-5 2011 We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo. Benzo(a)pyrene 78-83 aryl-hydrocarbon receptor Mus musculus 119-122 20478378-1 2010 We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs). Benzo(a)pyrene 201-204 aryl-hydrocarbon receptor Mus musculus 39-64 20478378-1 2010 We previously reported upregulation of aryl hydrocarbon receptor (AhR) expression as a mechanism by which overexpression of Cu/Zn-superoxide dismutase (SOD) and/or catalase accelerates benzo(a)pyrene (BaP) detoxification in mouse aorta endothelial cells (MAECs). Benzo(a)pyrene 201-204 aryl-hydrocarbon receptor Mus musculus 66-69 19216581-0 2009 Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure. Benzo(a)pyrene 21-35 aryl-hydrocarbon receptor Mus musculus 39-42 19666105-0 2009 Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Benzo(a)pyrene 73-87 aryl-hydrocarbon receptor Mus musculus 126-151 19666105-4 2009 After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells. Benzo(a)pyrene 6-9 aryl-hydrocarbon receptor Mus musculus 34-37 19666105-6 2009 Moreover, knockdown of AhR with RNA interference diminished the Cu/Zn-SOD and catalase enhancement of CYP1A1 expression, GST activity, and BaP detoxification. Benzo(a)pyrene 139-142 aryl-hydrocarbon receptor Mus musculus 23-26 19755658-1 2009 Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 43-68 19755658-1 2009 Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 70-73 19755658-1 2009 Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 43-68 19755658-1 2009 Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 70-73 19351592-0 2009 Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor. Benzo(a)pyrene 47-61 aryl-hydrocarbon receptor Mus musculus 91-116 19351592-1 2009 We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Benzo(a)pyrene 35-49 aryl-hydrocarbon receptor Mus musculus 112-137 19351592-1 2009 We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Benzo(a)pyrene 35-49 aryl-hydrocarbon receptor Mus musculus 139-142 19351592-1 2009 We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Benzo(a)pyrene 51-56 aryl-hydrocarbon receptor Mus musculus 112-137 19351592-1 2009 We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Benzo(a)pyrene 51-56 aryl-hydrocarbon receptor Mus musculus 139-142 19216581-2 2009 The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis. Benzo(a)pyrene 66-68 aryl-hydrocarbon receptor Mus musculus 4-15 19216581-2 2009 The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis. Benzo(a)pyrene 66-68 aryl-hydrocarbon receptor Mus musculus 17-20 19216581-2 2009 The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis. Benzo(a)pyrene 97-99 aryl-hydrocarbon receptor Mus musculus 4-15 19216581-2 2009 The Ah receptor (Ahr) is important in the metabolic activation of BP and is therefore central to BP-induced carcinogenesis. Benzo(a)pyrene 97-99 aryl-hydrocarbon receptor Mus musculus 17-20 19216581-7 2009 On the other hand, the Ahr(-/-) mice appear to have a lower metabolic clearance of BP resulting in increased levels of DNA and protein adducts and of unmetabolized BP. Benzo(a)pyrene 83-85 aryl-hydrocarbon receptor Mus musculus 23-26 19216581-7 2009 On the other hand, the Ahr(-/-) mice appear to have a lower metabolic clearance of BP resulting in increased levels of DNA and protein adducts and of unmetabolized BP. Benzo(a)pyrene 164-166 aryl-hydrocarbon receptor Mus musculus 23-26 19216581-9 2009 In addition, the systemic uptake of BP is increased in the Ahr(-/-) mice as compared with the wild-type mice. Benzo(a)pyrene 36-38 aryl-hydrocarbon receptor Mus musculus 59-62 19216581-10 2009 Hence, the lack of a functional Ah receptor results in an Ahr-independent biotransformation of BP with a slower clearance of BP and higher levels of DNA and protein adducts, but the distribution and levels of BP and BP-protein adducts are clearly dependent on the route of exposure. Benzo(a)pyrene 95-97 aryl-hydrocarbon receptor Mus musculus 32-43 19216581-10 2009 Hence, the lack of a functional Ah receptor results in an Ahr-independent biotransformation of BP with a slower clearance of BP and higher levels of DNA and protein adducts, but the distribution and levels of BP and BP-protein adducts are clearly dependent on the route of exposure. Benzo(a)pyrene 95-97 aryl-hydrocarbon receptor Mus musculus 58-61 18179178-1 2008 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates most of the toxic effects of numerous chlorinated (e.g., TCDD) and nonchlorinated polycyclic aromatic compounds (e.g., benzo[ a]pyrene). Benzo(a)pyrene 212-227 aryl-hydrocarbon receptor Mus musculus 4-29 18096572-4 2008 In contrast, activation of the AHR with 3-methylcholanthrene or benzo[a]pyrene resulted in predominant formation of AHR*ARNT complexes. Benzo(a)pyrene 64-78 aryl-hydrocarbon receptor Mus musculus 31-34 18096572-4 2008 In contrast, activation of the AHR with 3-methylcholanthrene or benzo[a]pyrene resulted in predominant formation of AHR*ARNT complexes. Benzo(a)pyrene 64-78 aryl-hydrocarbon receptor Mus musculus 116-119 18664595-6 2008 In 3T3-L1 cells, treatment with AhR agonists including benzo[a]pyrene and 3-methylcholanthrene reproduced the antiadipogenic effect of C. militaris. Benzo(a)pyrene 55-69 aryl-hydrocarbon receptor Mus musculus 32-35 18179178-1 2008 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates most of the toxic effects of numerous chlorinated (e.g., TCDD) and nonchlorinated polycyclic aromatic compounds (e.g., benzo[ a]pyrene). Benzo(a)pyrene 212-227 aryl-hydrocarbon receptor Mus musculus 31-34 17681673-7 2007 Since the toxic effects of benzo(a)pyrene are aryl hydrocarbon receptor (AhR)-dependent, we examined the effects of the very potent AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the growth and functional differentiation of mouse BM-derived DCs. Benzo(a)pyrene 27-41 aryl-hydrocarbon receptor Mus musculus 73-76 17681673-15 2007 Taken together, although benzo(a)pyrene and TCDD exert their effects via binding to AhR, their effects on the growth and functional differentiation of bone marrow-derived DCs are different. Benzo(a)pyrene 25-39 aryl-hydrocarbon receptor Mus musculus 84-87 16256281-8 2006 Cyp1a2 knockout reduced skin BAP adduct levels 50% and AHR knockout reduced skin BAP adduct levels by 90%. Benzo(a)pyrene 81-84 aryl-hydrocarbon receptor Mus musculus 55-58 17433523-0 2007 Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation. Benzo(a)pyrene 51-65 aryl-hydrocarbon receptor Mus musculus 13-38 17049425-0 2006 Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice. Benzo(a)pyrene 25-39 aryl-hydrocarbon receptor Mus musculus 82-85 17049425-2 2006 The Ah receptor (Ahr) is involved in the metabolic activation of BP and is therefore important in the induction of chemical carcinogenesis. Benzo(a)pyrene 65-67 aryl-hydrocarbon receptor Mus musculus 4-15 17049425-2 2006 The Ah receptor (Ahr) is involved in the metabolic activation of BP and is therefore important in the induction of chemical carcinogenesis. Benzo(a)pyrene 65-67 aryl-hydrocarbon receptor Mus musculus 17-20 17049425-3 2006 In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice. Benzo(a)pyrene 78-80 aryl-hydrocarbon receptor Mus musculus 40-43 17049425-3 2006 In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice. Benzo(a)pyrene 78-80 aryl-hydrocarbon receptor Mus musculus 120-123 17049425-3 2006 In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice. Benzo(a)pyrene 78-80 aryl-hydrocarbon receptor Mus musculus 120-123 17049425-3 2006 In this study, the relationship between Ahr genotype and biotransformation of BP in internal organs was investigated in Ahr (+/+), Ahr (+/-) and Ahr (-/-) mice. Benzo(a)pyrene 78-80 aryl-hydrocarbon receptor Mus musculus 120-123 17049425-8 2006 Analyzed by HPLC-fluorescence, there were increased levels of protein and DNA adducts, metabolites, conjugates and unmetabolized BP in the internal organs of Ahr (-/-) as compared to Ahr (+/+) and Ahr (+/-) mice. Benzo(a)pyrene 129-131 aryl-hydrocarbon receptor Mus musculus 158-161 17049425-9 2006 This may be partly explained by a delayed bioactivation of BP in the Ahr deficient mice. Benzo(a)pyrene 59-61 aryl-hydrocarbon receptor Mus musculus 69-72 17049425-10 2006 The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP. Benzo(a)pyrene 4-6 aryl-hydrocarbon receptor Mus musculus 34-37 17049425-10 2006 The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP. Benzo(a)pyrene 4-6 aryl-hydrocarbon receptor Mus musculus 72-75 17049425-10 2006 The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP. Benzo(a)pyrene 109-111 aryl-hydrocarbon receptor Mus musculus 34-37 17049425-10 2006 The BP metabolism observed in the Ahr (-/-) mice is also evidence of an Ahr independent biotransformation of BP. Benzo(a)pyrene 109-111 aryl-hydrocarbon receptor Mus musculus 72-75 17275222-5 2007 Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation. Benzo(a)pyrene 23-25 aryl-hydrocarbon receptor Mus musculus 70-73 17275222-5 2007 Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation. Benzo(a)pyrene 23-25 aryl-hydrocarbon receptor Mus musculus 109-112 17275222-5 2007 Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation. Benzo(a)pyrene 151-153 aryl-hydrocarbon receptor Mus musculus 70-73 17275222-5 2007 Some of the effects of BP were dependent on arylhydrocarbon receptor (AhR), because alpha-naphthoflavone, an AhR antagonist, suppressed the effects of BP on IL-12 production and T cell stimulating ability, but not on DC proliferation. Benzo(a)pyrene 151-153 aryl-hydrocarbon receptor Mus musculus 109-112 17145695-3 2006 Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Benzo(a)pyrene 195-209 aryl-hydrocarbon receptor Mus musculus 160-185 17145695-3 2006 Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Benzo(a)pyrene 195-209 aryl-hydrocarbon receptor Mus musculus 187-190 17145695-3 2006 Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Benzo(a)pyrene 211-214 aryl-hydrocarbon receptor Mus musculus 160-185 17145695-5 2006 A systems biology paradigm that combined approaches from genomics, transcriptomics, and bioinformatics revealed that the global response of murine metanephric cultures to BaP involves downregulation of Ahr and disruption of downstream targets of Wt1. Benzo(a)pyrene 171-174 aryl-hydrocarbon receptor Mus musculus 202-205 18958682-7 2006 Similarly, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), which are AhR ligands, induced remarkably similar changes in gene expression compared to DEP extracts. Benzo(a)pyrene 58-72 aryl-hydrocarbon receptor Mus musculus 92-95 15034205-1 2004 Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 97-122 15667830-4 2005 BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)). Benzo(a)pyrene 15-17 aryl-hydrocarbon receptor Mus musculus 78-103 15667830-4 2005 BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)). Benzo(a)pyrene 15-17 aryl-hydrocarbon receptor Mus musculus 105-108 15667830-4 2005 BM toxicity by BP is restored in congenic mice expressing a weakly responsive aryl hydrocarbon receptor (AhR(d) replaces AhR(b)). Benzo(a)pyrene 15-17 aryl-hydrocarbon receptor Mus musculus 121-124 15621696-0 2004 Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 120-123 15034205-1 2004 Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 124-127 15034205-1 2004 Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 97-122 15034205-1 2004 Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 124-127 11577022-4 2001 Although Cyp1a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein was uninducible. Benzo(a)pyrene 58-72 aryl-hydrocarbon receptor Mus musculus 33-36 14613719-0 2003 Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. Benzo(a)pyrene 28-42 aryl-hydrocarbon receptor Mus musculus 87-98 14613719-2 2003 Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 40-51 14613719-2 2003 Benzo(a)pyrene (BP), a much more potent Ah receptor ligand, shows very different responses that nevertheless depend on CYP1B1. Benzo(a)pyrene 16-18 aryl-hydrocarbon receptor Mus musculus 40-51 14613719-4 2003 In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected. Benzo(a)pyrene 60-62 aryl-hydrocarbon receptor Mus musculus 37-40 14613719-4 2003 In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected. Benzo(a)pyrene 60-62 aryl-hydrocarbon receptor Mus musculus 42-48 12884409-0 2003 Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene. Benzo(a)pyrene 115-129 aryl-hydrocarbon receptor Mus musculus 23-48 12884409-1 2003 Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 52-77 12884409-1 2003 Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 79-82 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 121-135 aryl-hydrocarbon receptor Mus musculus 4-15 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 121-135 aryl-hydrocarbon receptor Mus musculus 17-20 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 137-139 aryl-hydrocarbon receptor Mus musculus 4-15 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 137-139 aryl-hydrocarbon receptor Mus musculus 17-20 12455047-5 2003 Wild-type [AHR (+/+)] mice or mice lacking the gene for the AHR were treated with a single dose (100 micromol/kg) of BP or MC, and hepatic DNA adducts were analyzed by (32)P-postlabeling. Benzo(a)pyrene 117-119 aryl-hydrocarbon receptor Mus musculus 60-63 12455047-6 2003 BP induced multiple hepatic DNA adducts in wild-type as well as AHR-null animals, suggesting the existence of AHR-independent mechanisms for BP metabolic activation. Benzo(a)pyrene 0-2 aryl-hydrocarbon receptor Mus musculus 64-67 12455047-6 2003 BP induced multiple hepatic DNA adducts in wild-type as well as AHR-null animals, suggesting the existence of AHR-independent mechanisms for BP metabolic activation. Benzo(a)pyrene 0-2 aryl-hydrocarbon receptor Mus musculus 110-113 11755119-3 2001 Baicalein added in vitro decreased liver microsomal benzo[a]pyrene hydroxylation (AHH) activity with an ic(50) of 33.9 +/- 1.4 microM at 100 microM benzo[a]pyrene. Benzo(a)pyrene 52-66 aryl-hydrocarbon receptor Mus musculus 82-85 14530333-7 2003 In contrast, benzo(a)pyrene, another AHR ligand, still caused thymic involution in Lck-Cre;Arnt(flox/Delta) mice. Benzo(a)pyrene 13-27 aryl-hydrocarbon receptor Mus musculus 37-40 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 82-106 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 108-111 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 82-106 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 16-21 aryl-hydrocarbon receptor Mus musculus 108-111 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 248-253 aryl-hydrocarbon receptor Mus musculus 82-106 11733032-3 2001 Benzo[a]pyrene (B[a]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand-activated transcription factor with high affinities for aromatic compounds such as B[a]P and dioxin. Benzo(a)pyrene 248-253 aryl-hydrocarbon receptor Mus musculus 108-111 11577022-6 2001 CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs. Benzo(a)pyrene 124-138 aryl-hydrocarbon receptor Mus musculus 64-67 11577022-6 2001 CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs. Benzo(a)pyrene 124-138 aryl-hydrocarbon receptor Mus musculus 142-145 11577022-6 2001 CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs. Benzo(a)pyrene 124-138 aryl-hydrocarbon receptor Mus musculus 142-145 10860937-11 2000 These results suggest that c-Ha-ras activation in vSMCs by BaP involves a redox-sensitive mechanism that is coupled to AhR receptor-dependent functions. Benzo(a)pyrene 59-62 aryl-hydrocarbon receptor Mus musculus 119-122 11096091-0 2001 Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. Benzo(a)pyrene 162-176 aryl-hydrocarbon receptor Mus musculus 31-34 11096091-0 2001 Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. Benzo(a)pyrene 162-176 aryl-hydrocarbon receptor Mus musculus 36-39 11096091-8 2001 Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 54-57 11096091-8 2001 Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 133-136 11159756-0 2001 Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Benzo(a)pyrene 74-88 aryl-hydrocarbon receptor Mus musculus 0-25 10860937-0 2000 Activation of c-Ha-ras by benzo(a)pyrene in vascular smooth muscle cells involves redox stress and aryl hydrocarbon receptor. Benzo(a)pyrene 26-40 aryl-hydrocarbon receptor Mus musculus 99-124 10860937-6 2000 Ellipticine (0.01 nM), a known inhibitor of cytochrome P450 metabolism and aryl hydrocarbon receptor (AhR) antagonist, inhibited c-Ha-ras induction by BaP (3 microM). Benzo(a)pyrene 151-154 aryl-hydrocarbon receptor Mus musculus 75-100 10860937-6 2000 Ellipticine (0.01 nM), a known inhibitor of cytochrome P450 metabolism and aryl hydrocarbon receptor (AhR) antagonist, inhibited c-Ha-ras induction by BaP (3 microM). Benzo(a)pyrene 151-154 aryl-hydrocarbon receptor Mus musculus 102-105 11780955-0 2001 Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene. Benzo(a)pyrene 116-130 aryl-hydrocarbon receptor Mus musculus 23-48 11780955-1 2001 Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 25-50 11780955-1 2001 Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 52-55 11780955-1 2001 Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction. Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 25-50 11780955-1 2001 Benzo(a)pyrene (BaP), an aryl hydrocarbon receptor (AhR) ligand present in cigarette smoke and car exhaust, is thought to have negative effects on male reproduction. Benzo(a)pyrene 16-19 aryl-hydrocarbon receptor Mus musculus 52-55 11780955-2 2001 We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm. Benzo(a)pyrene 21-24 aryl-hydrocarbon receptor Mus musculus 47-50 11780955-2 2001 We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm. Benzo(a)pyrene 21-24 aryl-hydrocarbon receptor Mus musculus 221-224 11780955-2 2001 We hypothesized that BaP damages sperm through AhR activation, phase I enzyme induction, DNA adduct formation, and increased germ cell apoptosis in the testis, and that resveratrol, a natural competitive inhibitor of the AhR found in some red wines, could prevent the adverse effects of BaP on sperm. Benzo(a)pyrene 287-290 aryl-hydrocarbon receptor Mus musculus 221-224 11780955-14 2001 The natural AhR antagonist, resveratrol diminished BaP-induced DNA adducts and apoptosis in seminiferous tubules. Benzo(a)pyrene 51-54 aryl-hydrocarbon receptor Mus musculus 12-15 10656108-8 1998 Furthermore, we determined that the D2.B6N-Asp1b mouse expresses both the D2 phenotype and genotype at the Ahr locus, i.e., zoxazolamine paralysis and T to C and G to A transition mutations in the Ahr cDNA at bp sites 3330 and 3336, respectively. Benzo(a)pyrene 209-211 aryl-hydrocarbon receptor Mus musculus 107-110 10639156-0 2000 Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 59-84 9448724-3 1998 In contrast, this AHR-deficient line expressed a 4S protein which efficiently binds BP as it does in hepatic cytosol from C57BL/6 mice. Benzo(a)pyrene 84-86 aryl-hydrocarbon receptor Mus musculus 18-21 9448724-4 1998 In vivo BP exposure in AHR-deficient mice proved the inability to sustain any CYP1A1 mRNA or CYP1A1 protein induction. Benzo(a)pyrene 8-10 aryl-hydrocarbon receptor Mus musculus 23-26 8692887-1 1996 The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Benzo(a)pyrene 140-154 aryl-hydrocarbon receptor Mus musculus 4-15 9415707-3 1997 BaP-inducible DNA binding activity was demonstrated at a site located -30 relative to the major start site cluster at +1 that exhibits extensive homology to a consensus aryl hydrocarbon response element (AHRE), as well as a site located at -543 that contains a consensus electrophile response element (EpRE). Benzo(a)pyrene 0-3 aryl-hydrocarbon receptor Mus musculus 204-208 9415707-5 1997 The use of monoclonal antibodies to the aryl hydrocarbon receptor transcription factor in competition electrophoretic mobility shift assays indicated this protein is specifically induced by BaP to interact at the AHRE within the c-Ha-ras 5" regulatory region. Benzo(a)pyrene 190-193 aryl-hydrocarbon receptor Mus musculus 213-217 9006915-2 1997 Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR. Benzo(a)pyrene 123-137 aryl-hydrocarbon receptor Mus musculus 39-42 9006915-2 1997 Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR. Benzo(a)pyrene 123-137 aryl-hydrocarbon receptor Mus musculus 164-167 9006915-2 1997 Although physiological ligands for the AhR have not been identified, carcinogenic polycyclic aromatic hydrocarbons such as Benzo[a]pyrene (B[a]P) are high affinity AhR ligands that induce nuclear translocation and sequence-specific DNA binding of the AhR. Benzo(a)pyrene 123-137 aryl-hydrocarbon receptor Mus musculus 164-167 8967965-1 1996 Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 5-19 aryl-hydrocarbon receptor Mus musculus 190-215 8967965-1 1996 Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 5-19 aryl-hydrocarbon receptor Mus musculus 217-220 8692887-1 1996 The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Benzo(a)pyrene 140-154 aryl-hydrocarbon receptor Mus musculus 17-20 8148869-8 1993 Our data suggest that the Ahd-4 gene in murine cell cultures is regulated by three distinct mechanisms: Ah receptor-mediated induction by TCDD or benzo[a]pyrene, CYP1A1 metabolism-dependent repression, and Chr 7-mediated putative derepression. Benzo(a)pyrene 146-160 aryl-hydrocarbon receptor Mus musculus 104-115 35057794-10 2022 RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR. Benzo(a)pyrene 13-16 aryl-hydrocarbon receptor Mus musculus 327-330 34890772-0 2022 The behavioral effects of gestational and lactational benzo(a)pyrene exposure vary by sex and genotype in mice with differences at the Ahr and Cyp1a2 loci. Benzo(a)pyrene 54-68 aryl-hydrocarbon receptor Mus musculus 135-138 34890772-4 2022 Our studies were designed to look for genotype and sex differences in susceptibility to gestational and lactational exposure to BaP using a mouse model with allelic differences in the aryl hydrocarbon receptor and the xenobiotic metabolizing enzyme CYP1A2. Benzo(a)pyrene 128-131 aryl-hydrocarbon receptor Mus musculus 184-209 34290363-5 2021 In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles. Benzo(a)pyrene 39-44 aryl-hydrocarbon receptor Mus musculus 104-107 35057794-0 2022 Molecular mechanism of benzo (a) pyrene regulating lipid metabolism via aryl hydrocarbon receptor. Benzo(a)pyrene 23-39 aryl-hydrocarbon receptor Mus musculus 72-97 35057794-1 2022 BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 12-28 aryl-hydrocarbon receptor Mus musculus 126-151 35057794-1 2022 BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 12-28 aryl-hydrocarbon receptor Mus musculus 153-156 35057794-1 2022 BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 30-33 aryl-hydrocarbon receptor Mus musculus 126-151 35057794-1 2022 BACKGROUND: Benzo (a) pyrene (BaP), a potent carcinogen, has been proved that it has toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway. Benzo(a)pyrene 30-33 aryl-hydrocarbon receptor Mus musculus 153-156 35057794-3 2022 This topic will verify whether BaP regulates lipid metabolism via AhR. Benzo(a)pyrene 31-34 aryl-hydrocarbon receptor Mus musculus 66-69 35567930-0 2022 Benzo(a)pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production. Benzo(a)pyrene 0-14 aryl-hydrocarbon receptor Mus musculus 62-87 35065163-10 2022 Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP. Benzo(a)pyrene 121-124 aryl-hydrocarbon receptor Mus musculus 30-33 35203386-0 2022 Aryl Hydrocarbon Receptor Activation by Benzo(a)pyrene Prevents Development of Septic Shock and Fatal Outcome in a Mouse Model of Systemic Salmonella enterica Infection. Benzo(a)pyrene 40-54 aryl-hydrocarbon receptor Mus musculus 0-25 35203386-1 2022 This study focused on immunomodulatory effects of aryl hydrocarbon receptor (AhR) activation through benzo(a)pyrene (BaP) during systemic bacterial infection. Benzo(a)pyrene 101-115 aryl-hydrocarbon receptor Mus musculus 50-75 35203386-1 2022 This study focused on immunomodulatory effects of aryl hydrocarbon receptor (AhR) activation through benzo(a)pyrene (BaP) during systemic bacterial infection. Benzo(a)pyrene 117-120 aryl-hydrocarbon receptor Mus musculus 50-75 34998820-2 2022 BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes. Benzo(a)pyrene 0-3 aryl-hydrocarbon receptor Mus musculus 31-56 34998820-2 2022 BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes. Benzo(a)pyrene 0-3 aryl-hydrocarbon receptor Mus musculus 58-61 34998820-2 2022 BaP acts as an agonist for the aryl hydrocarbon receptor (AHR), and is metabolized by AHR-inducing enzymes. Benzo(a)pyrene 0-3 aryl-hydrocarbon receptor Mus musculus 86-89 35057794-10 2022 RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR. Benzo(a)pyrene 161-164 aryl-hydrocarbon receptor Mus musculus 327-330 35057794-11 2022 CONCLUSION: BaP inhibit fat synthesis and oxidation while inducing inflammation by activating AhR, leading to WAT dysfunction and causing metabolic complications. Benzo(a)pyrene 12-15 aryl-hydrocarbon receptor Mus musculus 94-97