PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31258692-8 2019 Puerarin suppressed phosphatidylinositol-3 kinase (PI3K), phosphorylated (p)-protein kinase B (Akt) and p-mammalian target of rapamycin (mTOR) protein expression in HeLa cells. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 95-98 32399049-0 2020 Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 140-143 33164393-14 2020 This series of studies confirm that puerarin can treat hepatocellular carcinoma by blocking PTEN/Akt/GSK3beta cellular signaling pathway, so as to provide ideas for subsequent studies for the molecular mechanism of puerarin in the treatment of liver cancer. puerarin 36-44 AKT serine/threonine kinase 1 Homo sapiens 97-100 32294699-0 2020 Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 96-99 31258692-9 2019 These results indicate that Puerarin induces apoptosis in HPV-positive HeLa cervical cancer cells via inhibiting PI3K/Akt/mTOR signaling. puerarin 28-36 AKT serine/threonine kinase 1 Homo sapiens 118-121 28352705-8 2015 Expression levels of AKT, mTOR, P70S6K mRNAs, and phosphorylated proteins decreased significantly after action of puerarin at different concentrations. puerarin 114-122 AKT serine/threonine kinase 1 Homo sapiens 21-24 31162246-0 2019 Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 115-118 30284466-2 2018 Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. puerarin 32-40 AKT serine/threonine kinase 1 Homo sapiens 95-98 29037842-0 2017 Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-kappaB. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 119-122 29037842-6 2017 Pre-treatment with puerarin (50-200muM) for 1h significantly attenuated the ox-LDL-induced TF expression, augmented the phosphorylation of Akt, with a resultant increase of the NO production, and inhibited the activation of ERK1/2 and NF-kappaB (P<0.01). puerarin 19-27 AKT serine/threonine kinase 1 Homo sapiens 139-142 29037842-8 2017 SIGNIFICANCE: These results suggested that puerarin suppressed TF expression in HUVECs through activating the PI3K/Akt/endothelial nitric oxide synthase signaling pathway and inhibiting the activation of ERK1/2 and NF-kappaB. puerarin 43-51 AKT serine/threonine kinase 1 Homo sapiens 115-118 29113186-0 2017 Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 100-103 29113186-11 2017 Puerarin treatment suppressed the expression of p-Akt and Bcl-2 but promoted the expression of Bax and cleaved caspase-3 in SW1353 cells. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 50-53 29113186-12 2017 Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin. puerarin 215-223 AKT serine/threonine kinase 1 Homo sapiens 112-115 29113186-12 2017 Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin. puerarin 215-223 AKT serine/threonine kinase 1 Homo sapiens 142-145 28393209-0 2017 Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 92-95 26101183-0 2015 Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 92-95 26101183-4 2015 Puerarin attenuated the DEX-induced release of cytochrome c and cleavage of caspase-3, and treatment with puerarin inhibited the c-Jun N-terminal kinase (JNK) pathway and activated the phosphoinositide 3-kinase (PI3K)/Akt pathway in the hFOB1.19 cells. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 218-221 26101183-4 2015 Puerarin attenuated the DEX-induced release of cytochrome c and cleavage of caspase-3, and treatment with puerarin inhibited the c-Jun N-terminal kinase (JNK) pathway and activated the phosphoinositide 3-kinase (PI3K)/Akt pathway in the hFOB1.19 cells. puerarin 106-114 AKT serine/threonine kinase 1 Homo sapiens 218-221 26101183-5 2015 Furthermore, the Akt inhibitor, LY294002, partly eliminated the protective effect of puerarin on DEX-induced apoptosis, and puerarin combined with the JNK inhibitor, SP600125, suppressed DEX-induced apoptosis to a lesser extent than in the cells treated with SP600125 alone. puerarin 85-93 AKT serine/threonine kinase 1 Homo sapiens 17-20 26101183-6 2015 These results suggested that the JNK and PI3K/Akt signaling pathways mediate the inhibitory effects of puerarin on apoptosis in the hFOB1.19 cells. puerarin 103-111 AKT serine/threonine kinase 1 Homo sapiens 46-49 26101183-7 2015 In conclusion, puerarin prevented DEX-induced apoptosis of hFOB1.19 cells via inhibition of the JNK pathway and activation of the PI3K/Akt signaling pathway in the cells, dependent on the mitochondrial apoptotic pathway. puerarin 15-23 AKT serine/threonine kinase 1 Homo sapiens 135-138 23639192-0 2013 Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 154-157 24690262-7 2014 The present study suggests that puerarin exerts its protective action probably through reduction of NADPH oxidase-derived reactive oxygen species overproduction and activation of the PI3K/Akt/eNOS pathways. puerarin 32-40 AKT serine/threonine kinase 1 Homo sapiens 188-191 25173778-7 2015 Expressions of PI3K and p-Akt were downregulated by puerarin. puerarin 52-60 AKT serine/threonine kinase 1 Homo sapiens 26-29 22265823-0 2012 Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. puerarin 75-83 AKT serine/threonine kinase 1 Homo sapiens 34-37 23639192-10 2013 Moreover, we also demonstrate that puerarin functions at least partially through activation of MEK/ERK and PI3K/Akt signaling. puerarin 35-43 AKT serine/threonine kinase 1 Homo sapiens 112-115 22265823-3 2012 The presence of PI3K inhibitor LY294002 completely blocked puerarin-induced activation of Akt phosphorylation. puerarin 59-67 AKT serine/threonine kinase 1 Homo sapiens 90-93 22265823-8 2012 Collectively, these data suggest that the activation of PI3K/Akt pathway is involved in the protective effect of puerarin against MPP(+)-induced neuroblastoma SH-SY5Y cell death through inhibiting nuclear p53 accumulation and subsequently caspase-3-dependent PCD. puerarin 113-121 AKT serine/threonine kinase 1 Homo sapiens 61-64 18845176-10 2008 Taken together, these results suggest that puerarin augments cellular antioxidant defense capacity through ER-dependent HO-1 induction via the Gbeta1/PI3K/Akt-Nrf2 signaling pathway, thereby protecting cells from oxidative stress. puerarin 43-51 AKT serine/threonine kinase 1 Homo sapiens 155-158 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. puerarin 53-61 AKT serine/threonine kinase 1 Homo sapiens 161-164 21884717-8 2011 These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an estrogen receptor-mediated PI3K/Akt- and CaMKII/AMPK-dependent pathway. puerarin 28-36 AKT serine/threonine kinase 1 Homo sapiens 140-155 18692596-9 2008 To get further insights into the underlying mechanisms of these effects induced by puerarin, we measured telomerase activity and determined the phosphorylation of serine/threonine protein kinase Akt by using western blot. puerarin 83-91 AKT serine/threonine kinase 1 Homo sapiens 195-198 18692596-10 2008 Puerarin significantly increased telomerase activity and phosphorylation of Akt, a downstream effector of phosphoinositide 3-kinase (PI-3K). puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 76-79 18692596-12 2008 Taken together, the results of the present study indicated that puerarin delayed the onset of EPCs senescence, which may be related to the activation of telomerase through the PI-3K/Akt pathway. puerarin 64-72 AKT serine/threonine kinase 1 Homo sapiens 182-185 32860809-0 2020 Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells through PI3K/AKT pathway. puerarin 0-8 AKT serine/threonine kinase 1 Homo sapiens 143-146 32860809-13 2020 These results implicated that puerarin exhibited cytoprotective effects against H2O2-induced EndMT in HCAECs through alleviating oxidative stress, activating the PI3K/AKT pathway and limiting cell migration. puerarin 30-38 AKT serine/threonine kinase 1 Homo sapiens 167-170