PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23764356-6 2013 Liver histopathology also showed that puerarin reduced the incidence of liver lesions induced by CCl4. puerarin 38-46 C-C motif chemokine ligand 4 Rattus norvegicus 97-101 27677221-1 2016 In this study, we aim to explore the potential benefits of puerarin on metabolic function of liver fibrosis (LF) rat induced by carbon tetrachloride (CCl4), and to investigate with the underlying molecular mechanism targeted on liver and pancreas tissues. puerarin 59-67 C-C motif chemokine ligand 4 Rattus norvegicus 150-154 27677221-8 2016 Our findings demonstrate that puerarin contributes to attenuating the metabolic dysfunctions of CCl4-damaged liver and pancreas, in which the possible mechanisms may be linked to inhibition of inflammatory stress and normalization of metabolic homoeostasis in the liver and pancreas. puerarin 30-38 C-C motif chemokine ligand 4 Rattus norvegicus 96-100 23764356-1 2013 The protective effects of puerarin on liver damage were evaluated by carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. puerarin 26-34 C-C motif chemokine ligand 4 Rattus norvegicus 91-95 23764356-4 2013 In addition, puerarin at different doses significantly decreased (p<0.05) the level of hepatic thiobarbituric acid reactive substances compared to the CCl4-treated group. puerarin 13-21 C-C motif chemokine ligand 4 Rattus norvegicus 154-158 23764356-5 2013 Furthermore, the treatment of puerarin was also found to significantly increase the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glutathione content at least 40%, 12%, 25%, 52%, 17% and 44% in the liver of CCl4-treated rats, respectively. puerarin 30-38 C-C motif chemokine ligand 4 Rattus norvegicus 285-289 23764356-7 2013 The results suggest that puerarin exhibits potent hepatoprotective effects on CCl4-induced liver damages in rats, and that the hepatoprotective effects of puerarin may be due to both the inhibition of lipid peroxidation and to increase of antioxidant enzymes activity. puerarin 25-33 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 23146695-0 2013 Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. puerarin 0-8 C-C motif chemokine ligand 4 Rattus norvegicus 43-47 23500774-0 2013 Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-gamma expression and inhibition of PI3K/Akt pathway. puerarin 25-33 C-C motif chemokine ligand 4 Rattus norvegicus 37-41 23500774-2 2013 In this study, we aimed to investigate the therapeutic effects of puerarin (PR), an active ingredient from kudzu root, on CCl4-induced HF rats. puerarin 66-74 C-C motif chemokine ligand 4 Rattus norvegicus 122-126