PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22323590-3 2012 Cystathionine gamma-lyase (CSE) is a major H(2)S-producing enzyme in the cardiovascular system that uses cysteine as the main substrate. Cysteine 105-113 cystathionine gamma-lyase Homo sapiens 0-25 22323590-3 2012 Cystathionine gamma-lyase (CSE) is a major H(2)S-producing enzyme in the cardiovascular system that uses cysteine as the main substrate. Cysteine 105-113 cystathionine gamma-lyase Homo sapiens 27-30 22323590-9 2012 Translocation of CSE to mitochondria metabolized cysteine, produced H(2)S inside mitochondria, and increased ATP production. Cysteine 49-57 cystathionine gamma-lyase Homo sapiens 17-20 22093698-0 2012 New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine gamma-lyase. Cysteine 80-88 cystathionine gamma-lyase Homo sapiens 178-203 21275900-2 2011 CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine. Cysteine 168-178 cystathionine gamma-lyase Homo sapiens 108-111 22309020-2 2011 In the vascular system, H2S is synthesized from cysteine by cystathionine-gamma-lyase (CSE) in smooth muscle cells (SMC) and 3- mercaptopyruvate sulfuresterase (3MST) and CSE in the endothelial cells. Cysteine 48-56 cystathionine gamma-lyase Homo sapiens 60-85 22309020-2 2011 In the vascular system, H2S is synthesized from cysteine by cystathionine-gamma-lyase (CSE) in smooth muscle cells (SMC) and 3- mercaptopyruvate sulfuresterase (3MST) and CSE in the endothelial cells. Cysteine 48-56 cystathionine gamma-lyase Homo sapiens 87-90 21467968-2 2011 H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood. Cysteine 34-44 cystathionine gamma-lyase Homo sapiens 115-140 21467968-2 2011 H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood. Cysteine 34-44 cystathionine gamma-lyase Homo sapiens 142-145 21275893-2 2011 In the vasculature, cystathionine-gamma-lyase (CSE) is the main enzyme responsible for H(2)S biosynthesis starting from the substrate e.g. L-cysteine. Cysteine 139-149 cystathionine gamma-lyase Homo sapiens 20-45 21275893-2 2011 In the vasculature, cystathionine-gamma-lyase (CSE) is the main enzyme responsible for H(2)S biosynthesis starting from the substrate e.g. L-cysteine. Cysteine 139-149 cystathionine gamma-lyase Homo sapiens 47-50 21275895-3 2011 The production of H(2)S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase. Cysteine 29-39 cystathionine gamma-lyase Homo sapiens 79-104 24278674-1 2012 Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-gamma-lyase and cystathionine-beta-synthase. Cysteine 127-135 cystathionine gamma-lyase Homo sapiens 198-223 21886822-9 2011 These effects of L-cysteine were blocked by the inhibitors of CBS and CSE. Cysteine 17-27 cystathionine gamma-lyase Homo sapiens 70-73 22115353-8 2011 As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide. Cysteine 154-162 cystathionine gamma-lyase Homo sapiens 35-60 20545623-2 2010 H2S is synthesized from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase. Cysteine 24-34 cystathionine gamma-lyase Homo sapiens 73-98 20825409-1 2010 BACKGROUND AND PURPOSE: Hydrogen sulphide (H(2)S), considered as a novel gas transmitter, is produced endogenously in mammalian tissue from L-cysteine by two enzymes, cystathionine beta-synthase and cystathionine gamma-lyase. Cysteine 140-150 cystathionine gamma-lyase Homo sapiens 199-224 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cysteine 106-114 cystathionine gamma-lyase Homo sapiens 0-25 20440442-1 2010 Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-beta-synthase and cystathionine-gamma-lyase (CSE). Cysteine 99-109 cystathionine gamma-lyase Homo sapiens 172-197 20440442-1 2010 Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-beta-synthase and cystathionine-gamma-lyase (CSE). Cysteine 99-109 cystathionine gamma-lyase Homo sapiens 199-202 20566639-2 2010 However, premature infants or patients with hepatic failure may require dietary cysteine due to a lack of cystathionine gamma-lyase (CTH), a key trans-sulfuration enzyme. Cysteine 80-88 cystathionine gamma-lyase Homo sapiens 106-131 20566639-2 2010 However, premature infants or patients with hepatic failure may require dietary cysteine due to a lack of cystathionine gamma-lyase (CTH), a key trans-sulfuration enzyme. Cysteine 80-88 cystathionine gamma-lyase Homo sapiens 133-136 19803741-1 2010 Hydrogen sulfide (H(2)S) is an important signaling molecule produced from L-cysteine by cystathionine beta-synthetase (CBS) or cystathionine gamma-lyase (CSE). Cysteine 74-84 cystathionine gamma-lyase Homo sapiens 127-152 19803741-1 2010 Hydrogen sulfide (H(2)S) is an important signaling molecule produced from L-cysteine by cystathionine beta-synthetase (CBS) or cystathionine gamma-lyase (CSE). Cysteine 74-84 cystathionine gamma-lyase Homo sapiens 154-157 20546998-1 2010 Hydrogen sulfide (H(2)S) formed from l-cysteine by multiple enzymes including cystathionine-gamma-lyase (CSE) is now considered a gasotransmitter in the mammalian body. Cysteine 37-47 cystathionine gamma-lyase Homo sapiens 78-103 20546998-1 2010 Hydrogen sulfide (H(2)S) formed from l-cysteine by multiple enzymes including cystathionine-gamma-lyase (CSE) is now considered a gasotransmitter in the mammalian body. Cysteine 37-47 cystathionine gamma-lyase Homo sapiens 105-108 20063035-5 2010 CSE inhibitor blocked the inhibitory effect of l-cysteine. Cysteine 47-57 cystathionine gamma-lyase Homo sapiens 0-3 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cysteine 106-114 cystathionine gamma-lyase Homo sapiens 27-30 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cysteine 182-190 cystathionine gamma-lyase Homo sapiens 0-25 19486201-1 2009 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. Cysteine 182-190 cystathionine gamma-lyase Homo sapiens 27-30 19285949-3 2009 H(2)S is a gas that can be formed by the action of two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, both involved in the metabolism of cysteine. Cysteine 158-166 cystathionine gamma-lyase Homo sapiens 64-89 18520135-2 2008 Reduced sulfur is also produced via the desulfuration of cysteine by several sulfurtransferases present in mammalian tissues; these enzymes include gamma-cystathionase (gamma-CST), and 3-mercaptopyruvate sulfurtransferase (3-MST). Cysteine 57-65 cystathionine gamma-lyase Homo sapiens 148-167 18476726-1 2008 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme, which functions in the transsulfuration pathway that converts homocysteine to cysteine. Cysteine 156-164 cystathionine gamma-lyase Homo sapiens 6-31 18476726-1 2008 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme, which functions in the transsulfuration pathway that converts homocysteine to cysteine. Cysteine 156-164 cystathionine gamma-lyase Homo sapiens 33-36 19261609-2 2009 It is widely assumed that desulfhydration of cysteine is the major source of H(2)S in mammals and is catalyzed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE). Cysteine 45-53 cystathionine gamma-lyase Homo sapiens 184-209 19261609-2 2009 It is widely assumed that desulfhydration of cysteine is the major source of H(2)S in mammals and is catalyzed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE). Cysteine 45-53 cystathionine gamma-lyase Homo sapiens 211-214 19261609-3 2009 In this study, we demonstrate that the profligacy of human CSE results in a variety of reactions that generate H(2)S from cysteine and homocysteine. Cysteine 122-130 cystathionine gamma-lyase Homo sapiens 59-62 18520135-2 2008 Reduced sulfur is also produced via the desulfuration of cysteine by several sulfurtransferases present in mammalian tissues; these enzymes include gamma-cystathionase (gamma-CST), and 3-mercaptopyruvate sulfurtransferase (3-MST). Cysteine 57-65 cystathionine gamma-lyase Homo sapiens 169-178 17948022-2 2007 The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase. Cysteine 27-37 cystathionine gamma-lyase Homo sapiens 77-102 18029544-2 2008 H(2)S is produced endogenously in rat arteries from cysteine by CSE. Cysteine 52-60 cystathionine gamma-lyase Homo sapiens 64-67 18029544-6 2008 Artery homogenates converted cysteine to H(2)S, and the H(2)S production was inhibited by dl-propargylglycine, an inhibitor of CSE. Cysteine 29-37 cystathionine gamma-lyase Homo sapiens 127-130 17377202-3 2007 H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor. Cysteine 26-36 cystathionine gamma-lyase Homo sapiens 84-109 17377202-3 2007 H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor. Cysteine 26-36 cystathionine gamma-lyase Homo sapiens 111-114 16472173-3 2006 H(2)S is produced endogenously in mammalian tissues from L-cysteine metabolism mainly by 3 enzymes: cystathionine beta-synthetase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptosulfurtransferase (MST). Cysteine 57-67 cystathionine gamma-lyase Homo sapiens 137-162 16885444-4 2006 Alternatively, yeast and some bacteria assimilate sulfur into homocysteine, which serves as a sulfhydryl group donor in the synthesis of cysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyase. Cysteine 66-74 cystathionine gamma-lyase Homo sapiens 215-240 16428267-1 2006 Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase. Cysteine 102-112 cystathionine gamma-lyase Homo sapiens 153-178 16428267-1 2006 Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase. Cysteine 102-112 cystathionine gamma-lyase Homo sapiens 180-183 16781459-1 2006 Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored. Cysteine 170-180 cystathionine gamma-lyase Homo sapiens 92-117 16781459-1 2006 Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored. Cysteine 170-180 cystathionine gamma-lyase Homo sapiens 119-122 16781459-1 2006 Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored. Cysteine 182-187 cystathionine gamma-lyase Homo sapiens 92-117 16781459-1 2006 Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored. Cysteine 182-187 cystathionine gamma-lyase Homo sapiens 119-122 16781459-5 2006 Moreover, NO production in LPS-stimulated macrophages that are expressing CSE mRNA was significantly reduced by the addition of L-Cys, a substrate for H(2)S, but enhanced by the selective CSE inhibitor beta-cyano-L-alanine but not by the CBS inhibitor aminooxyacetic acid. Cysteine 128-133 cystathionine gamma-lyase Homo sapiens 74-77 16507767-1 2006 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulfuration pathway, which uses L-cysteine to produce hydrogen sulfide (H2S). Cysteine 93-103 cystathionine gamma-lyase Homo sapiens 0-25 16507767-1 2006 Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulfuration pathway, which uses L-cysteine to produce hydrogen sulfide (H2S). Cysteine 93-103 cystathionine gamma-lyase Homo sapiens 27-30 16472173-3 2006 H(2)S is produced endogenously in mammalian tissues from L-cysteine metabolism mainly by 3 enzymes: cystathionine beta-synthetase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptosulfurtransferase (MST). Cysteine 57-67 cystathionine gamma-lyase Homo sapiens 164-167 16192316-9 2006 Administration of L-cysteine, a CSE/CBS substrate, reduced rectal sensitivity to CRD (p < 0.05). Cysteine 18-28 cystathionine gamma-lyase Homo sapiens 32-35 9299397-1 1997 Hydrogen sulfide (H2S), which is well known as a toxic gas, is produced endogenously in mammalian tissues from L-cysteine mainly by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthetase and cystathionine gamma-lyase. Cysteine 111-121 cystathionine gamma-lyase Homo sapiens 212-237 15151507-3 2004 Recently, we discovered that cystathioninuria was caused by mutations in the CTH gene encoding cystathionine gamma-lyase, an enzyme that converts cystathionine to cysteine in the trans-sulfuration pathway. Cysteine 163-171 cystathionine gamma-lyase Homo sapiens 95-120 11010904-5 2000 The assimilatory sulfate reduction pathway was redirected to overproduce cysteine, and excess cysteine was converted to sulfide by cysteine desulfhydrase. Cysteine 94-102 cystathionine gamma-lyase Homo sapiens 131-153 10727430-1 2000 Cystathionine gamma-lyase (CGL) is the last enzyme of the trans-sulphuration pathway, which converts methionine into cysteine. Cysteine 117-125 cystathionine gamma-lyase Homo sapiens 0-25 10727430-1 2000 Cystathionine gamma-lyase (CGL) is the last enzyme of the trans-sulphuration pathway, which converts methionine into cysteine. Cysteine 117-125 cystathionine gamma-lyase Homo sapiens 27-30 10727430-5 2000 In human liver samples, CGL activity was only detected in adult tissue (68+/-9 nmol of cysteine/h per mg of protein), whereas activity in fetal, premature and full-term neonatal liver tissue was undetectable. Cysteine 87-95 cystathionine gamma-lyase Homo sapiens 24-27 16203678-4 2005 Of the two enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS), which utilize L-cysteine as substrate to form H2S, CSE is believed to be the key enzyme which forms H2S in the cardiovascular system. Cysteine 107-117 cystathionine gamma-lyase Homo sapiens 20-45 16203678-4 2005 Of the two enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS), which utilize L-cysteine as substrate to form H2S, CSE is believed to be the key enzyme which forms H2S in the cardiovascular system. Cysteine 107-117 cystathionine gamma-lyase Homo sapiens 47-50 16203678-4 2005 Of the two enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS), which utilize L-cysteine as substrate to form H2S, CSE is believed to be the key enzyme which forms H2S in the cardiovascular system. Cysteine 107-117 cystathionine gamma-lyase Homo sapiens 144-147 15347670-2 2004 CSE uses L-cysteine as a substrate to produce hydrogen sulfide (H2S). Cysteine 9-19 cystathionine gamma-lyase Homo sapiens 0-3 15497768-2 2004 Recent studies demonstrate a role of the transsulfuration enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, in catalyzing the desulfhydration of cysteine in brain and smooth muscle. Cysteine 163-171 cystathionine gamma-lyase Homo sapiens 67-92 12574942-1 2003 Hereditary cystathioninuria (MIM 219500) is presumed to be caused by deficiency of the activity of cystathionine gamma-lyase (cystathionase; CTH EC 4.4.1.1), which is normally required for the conversion of methionine into cysteine. Cysteine 223-231 cystathionine gamma-lyase Homo sapiens 99-124 12631446-2 2003 The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase. Cysteine 25-33 cystathionine gamma-lyase Homo sapiens 194-213 34725089-2 2021 In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884. Cysteine 277-285 cystathionine gamma-lyase Homo sapiens 220-245 8507876-3 1993 Cystathionine is subsequently cleaved to cysteine and alpha-ketobutyrate by the pyridoxal phosphate-dependent enzyme gamma-cystathionase. Cysteine 41-49 cystathionine gamma-lyase Homo sapiens 117-136 16348483-8 1991 These data indicate that the substrate for the reaction was cysteine and the enzyme responsible for H(2)S and pyruvate production was cysteine desulfhydrase (EC 4.4.1.1). Cysteine 60-68 cystathionine gamma-lyase Homo sapiens 134-156 16348483-9 1991 The enzyme had a K(m) of 1.32 mM and was inactivated by temperatures greater than 60 degrees C. Because cysteine is present in soil and cysteine desulfhydrase is an inducible enzyme, the potential for H(2)S production by this mechanism exists in terrestrial environments. Cysteine 104-112 cystathionine gamma-lyase Homo sapiens 136-158 24750035-12 2015 This novel molecular mechanism operating in the vasculature, corroborated by higher H2S levels in males, suggests that the L-cysteine/CSE/H2S pathway may be preferentially activated in males leading to gender-specific H2S biosynthesis. Cysteine 123-133 cystathionine gamma-lyase Homo sapiens 134-137 34725089-2 2021 In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884. Cysteine 277-285 cystathionine gamma-lyase Homo sapiens 247-250 34573121-5 2021 Molecular dynamics and molecular docking suggest that the disulfide bond formation induces the conformational change in the active site of CSE and consequently increases the affinity of the enzyme for the substrate L-cysteine. Cysteine 215-225 cystathionine gamma-lyase Homo sapiens 139-142 31893496-2 2019 In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST). Cysteine 61-69 cystathionine gamma-lyase Homo sapiens 191-212 34458274-6 2021 Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT). Cysteine 0-8 cystathionine gamma-lyase Homo sapiens 110-135 34458274-6 2021 Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT). Cysteine 0-8 cystathionine gamma-lyase Homo sapiens 137-140 34458274-7 2021 In normoxia, CBS and CSE inhibition had a mild impact on cysteine-sustained ATP production, pointing out the relevance of CAT + MpST pathway. Cysteine 57-65 cystathionine gamma-lyase Homo sapiens 21-24 34458274-9 2021 However, the relative contributions of each of these enzymes (CBS/CSE/MpST) on cysteine-derived ATP synthesis under hypoxia remains unclear, due to the lack of specific inhibitors. Cysteine 79-87 cystathionine gamma-lyase Homo sapiens 66-69 33522955-9 2021 RESULTS: Here, we reported that FOXC1 could inhibit the cysteine metabolism and increase reactive oxygen species (ROS) levels by regulating cysteine metabolism-related genes, cystathionine gamma-lyase (CTH). Cysteine 56-64 cystathionine gamma-lyase Homo sapiens 175-200 31893496-2 2019 In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST). Cysteine 59-69 cystathionine gamma-lyase Homo sapiens 191-212 33522955-9 2021 RESULTS: Here, we reported that FOXC1 could inhibit the cysteine metabolism and increase reactive oxygen species (ROS) levels by regulating cysteine metabolism-related genes, cystathionine gamma-lyase (CTH). Cysteine 140-148 cystathionine gamma-lyase Homo sapiens 175-200 32349316-13 2020 Nanoparticles (NPs) are produced in the extracellular space of bacterial cells exposed to cysteine and CdCl2 in a reaction that depends on S2- generation mediated by cysteine desulfhydrase enzymes and uses cellular biomolecules to stabilize the nanoparticle. Cysteine 90-98 cystathionine gamma-lyase Homo sapiens 166-188 30646578-4 2019 A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD. Cysteine 122-130 cystathionine gamma-lyase Homo sapiens 35-60 31468690-4 2019 CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion. Cysteine 84-92 cystathionine gamma-lyase Homo sapiens 0-3 31542487-8 2019 CYS produced relaxations of HCC and HPRA that were sensitive to ODQ and to inhibition of the H2S synthesizing enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS). Cysteine 0-3 cystathionine gamma-lyase Homo sapiens 119-144 31542487-8 2019 CYS produced relaxations of HCC and HPRA that were sensitive to ODQ and to inhibition of the H2S synthesizing enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS). Cysteine 0-3 cystathionine gamma-lyase Homo sapiens 146-149 31160338-6 2019 We observed that CPC inhibited the gamma-elimination reaction of cystathionine and H2S synthesis from cysteine by human CSE with Ki values of 50 +- 3 and 180 +- 15 mum, respectively. Cysteine 102-110 cystathionine gamma-lyase Homo sapiens 120-123 30646578-4 2019 A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD. Cysteine 122-130 cystathionine gamma-lyase Homo sapiens 62-65 30402624-4 2018 Herein, the single enzyme cystathionine gamma-lyase (CSE) is utilized to biomineralize CdS nanocrystals via the slow, but continuous turnover of the amino acid l-cysteine to produce H2S. Cysteine 160-170 cystathionine gamma-lyase Homo sapiens 26-51 30662667-1 2018 Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 55-63 cystathionine gamma-lyase Homo sapiens 117-142 30662667-1 2018 Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 55-63 cystathionine gamma-lyase Homo sapiens 144-147 30277497-1 2019 Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH). Cysteine 110-120 cystathionine gamma-lyase Homo sapiens 189-192 31148102-2 2019 H2S is synthesized from L-cysteine and/or L-homocysteine by cystathionine beta-synthase, cystathionine gamma-lyase, and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase. Cysteine 24-34 cystathionine gamma-lyase Homo sapiens 89-114 31527362-1 2019 Hydrogen sulfide (H2S), an endogenous gasotransmitter, is generated from L-cysteine by 3 distinct enzymes including cystathionine-gamma-lyase (CSE), and targets multiple molecules, thereby playing various roles in health and disease. Cysteine 73-83 cystathionine gamma-lyase Homo sapiens 116-141 31527362-1 2019 Hydrogen sulfide (H2S), an endogenous gasotransmitter, is generated from L-cysteine by 3 distinct enzymes including cystathionine-gamma-lyase (CSE), and targets multiple molecules, thereby playing various roles in health and disease. Cysteine 73-83 cystathionine gamma-lyase Homo sapiens 143-146 30402624-4 2018 Herein, the single enzyme cystathionine gamma-lyase (CSE) is utilized to biomineralize CdS nanocrystals via the slow, but continuous turnover of the amino acid l-cysteine to produce H2S. Cysteine 160-170 cystathionine gamma-lyase Homo sapiens 53-56 29317536-6 2018 Huntington"s disease (HD), a neurodegenerative disorder, is associated with disrupted cysteine metabolism caused by depletion of CSE leading to abnormal redox balance and stress response. Cysteine 86-94 cystathionine gamma-lyase Homo sapiens 129-132 28486919-4 2018 Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway. Cysteine 113-121 cystathionine gamma-lyase Homo sapiens 38-63 28486919-4 2018 Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway. Cysteine 113-121 cystathionine gamma-lyase Homo sapiens 65-68 29317536-8 2018 Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD. Cysteine 145-153 cystathionine gamma-lyase Homo sapiens 75-78 29507650-2 2018 H2S is produced from cysteine by enzymes, such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). Cysteine 21-29 cystathionine gamma-lyase Homo sapiens 85-110 29507650-2 2018 H2S is produced from cysteine by enzymes, such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). Cysteine 21-29 cystathionine gamma-lyase Homo sapiens 112-115 28705807-4 2017 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine 25-35 cystathionine gamma-lyase Homo sapiens 106-109 30393252-2 2018 H2S is produced from l-cysteine by pyridoxal 5"-phosphate (PLP)-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 121-146 30393252-2 2018 H2S is produced from l-cysteine by pyridoxal 5"-phosphate (PLP)-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 148-151 29259741-1 2017 Hydrogen sulfide is produced from l-cysteine by the action of both cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) and increasingly has been found to play a profound regulatory role in a range of physiological processes. Cysteine 34-44 cystathionine gamma-lyase Homo sapiens 67-92 29259741-1 2017 Hydrogen sulfide is produced from l-cysteine by the action of both cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) and increasingly has been found to play a profound regulatory role in a range of physiological processes. Cysteine 34-44 cystathionine gamma-lyase Homo sapiens 94-97 28705807-4 2017 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine 25-35 cystathionine gamma-lyase Homo sapiens 132-135 28705807-4 2017 The inhibitory effect of l-cysteine, but not NaHS, on PDE5 activity was blocked in cells transfected with CSE siRNA or treated with CSE inhibitor d,l-propargylglycine (dl-PPG), suggesting activation of CSE and generation of H2S in response to l-cysteine. Cysteine 25-35 cystathionine gamma-lyase Homo sapiens 132-135 28705807-5 2017 H2S levels were increased in response to l-cysteine, and the effect of l-cysteine was augmented by GSNO in a cGMP-dependent protein kinase-sensitive manner, suggesting augmentation of CSE/H2S by cGMP/PKG pathway. Cysteine 71-81 cystathionine gamma-lyase Homo sapiens 184-187 28291844-1 2017 Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1). Cysteine 56-66 cystathionine gamma-lyase Homo sapiens 144-163 28454695-7 2017 Transfection of syncytiotrophoblasts with CBS siRNA and CSE siRNA reversed the above effects of l-cysteine. Cysteine 96-106 cystathionine gamma-lyase Homo sapiens 56-59 28339573-1 2017 Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor. Cysteine 63-73 cystathionine gamma-lyase Homo sapiens 115-140 28339573-1 2017 Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor. Cysteine 63-73 cystathionine gamma-lyase Homo sapiens 142-145 28291844-1 2017 Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1). Cysteine 56-66 cystathionine gamma-lyase Homo sapiens 165-168 27934104-3 2016 In living systems, cystathionine gamma-lyase (CSE) can be overexpressed due to LPS, and H2Sn can be formed by CSE-mediated cysteine metabolism. Cysteine 123-131 cystathionine gamma-lyase Homo sapiens 19-44 27931022-1 2017 BACKGROUND: Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase. Cysteine 73-83 cystathionine gamma-lyase Homo sapiens 105-130 27931022-1 2017 BACKGROUND: Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase. Cysteine 73-83 cystathionine gamma-lyase Homo sapiens 132-135 27934104-3 2016 In living systems, cystathionine gamma-lyase (CSE) can be overexpressed due to LPS, and H2Sn can be formed by CSE-mediated cysteine metabolism. Cysteine 123-131 cystathionine gamma-lyase Homo sapiens 46-49 27934104-3 2016 In living systems, cystathionine gamma-lyase (CSE) can be overexpressed due to LPS, and H2Sn can be formed by CSE-mediated cysteine metabolism. Cysteine 123-131 cystathionine gamma-lyase Homo sapiens 110-113 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cysteine 52-62 cystathionine gamma-lyase Homo sapiens 19-22 27664576-9 2016 The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs. Cysteine 52-62 cystathionine gamma-lyase Homo sapiens 179-182 27708394-2 2016 It is endogenously synthesized mainly by two pyridoxal-5"-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-lyase (CSE). Cysteine 98-108 cystathionine gamma-lyase Homo sapiens 157-182 27708394-2 2016 It is endogenously synthesized mainly by two pyridoxal-5"-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-lyase (CSE). Cysteine 98-108 cystathionine gamma-lyase Homo sapiens 184-187 26467707-4 2016 Here we show that overexpression of cystathionine gamma-lyase, a central enzyme in cysteine metabolism, is protective in a Drosophila model for SCA3. Cysteine 83-91 cystathionine gamma-lyase Homo sapiens 36-61 26791043-1 2016 Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine. Cysteine 51-59 cystathionine gamma-lyase Homo sapiens 99-118 26791043-1 2016 Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine. Cysteine 51-59 cystathionine gamma-lyase Homo sapiens 120-123 27129884-2 2016 Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production. Cysteine 25-33 cystathionine gamma-lyase Homo sapiens 102-127 26820738-6 2016 Mechanistically, silencing of PTGR2 or addition of 15-keto-PGE2 suppressed the expressions of solute carrier family 7 member 11 (xCT) and cystathionine gamma-lyase (CTH), two important providers of intracellular cysteine for the generation of glutathione (GSH), which is widely accepted as the first-line antioxidative defense. Cysteine 212-220 cystathionine gamma-lyase Homo sapiens 138-163 26820738-6 2016 Mechanistically, silencing of PTGR2 or addition of 15-keto-PGE2 suppressed the expressions of solute carrier family 7 member 11 (xCT) and cystathionine gamma-lyase (CTH), two important providers of intracellular cysteine for the generation of glutathione (GSH), which is widely accepted as the first-line antioxidative defense. Cysteine 212-220 cystathionine gamma-lyase Homo sapiens 165-168 26667407-6 2016 Our detailed kinetic analyses demonstrate a robust capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CSE only. Cysteine 64-67 cystathionine gamma-lyase Homo sapiens 162-181 26667407-6 2016 Our detailed kinetic analyses demonstrate a robust capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CSE only. Cysteine 64-67 cystathionine gamma-lyase Homo sapiens 183-186 26667407-6 2016 Our detailed kinetic analyses demonstrate a robust capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CSE only. Cysteine 64-67 cystathionine gamma-lyase Homo sapiens 250-253 27365395-4 2016 Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production. Cysteine 198-206 cystathionine gamma-lyase Homo sapiens 172-175 27365395-6 2016 This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology. Cysteine 45-53 cystathionine gamma-lyase Homo sapiens 99-102 27035752-2 2016 Endogenous H2S is synthesized from l-cysteine via cystathionine beta-synthase and cystathionine gamma-lyase and it regulates multiple signaling pathways in mammalian cells. Cysteine 35-45 cystathionine gamma-lyase Homo sapiens 82-107 27118834-4 2016 A recombinant putative cystathionine gamma-lyase (smCSE) mineralizes CdS from an aqueous cadmium acetate solution via reactive H2S generation from l-cysteine and controls nanocrystal growth within the quantum confined size range. Cysteine 147-157 cystathionine gamma-lyase Homo sapiens 23-48 26890936-1 2016 BACKGROUND AND PURPOSE: Hydrogen sulfide (H2S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase. Cysteine 82-92 cystathionine gamma-lyase Homo sapiens 125-150 26890936-1 2016 BACKGROUND AND PURPOSE: Hydrogen sulfide (H2S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase. Cysteine 82-92 cystathionine gamma-lyase Homo sapiens 152-155 29899936-4 2016 Moreover, if we introduce cystathionine gamma-lyase (CSE), a specific enzyme converting cysteine into H2S, onto the vesicle membrane, the polymersomes can extend their responsive scope from H2S to a specific amino acid bioactivator. Cysteine 88-96 cystathionine gamma-lyase Homo sapiens 26-51 29899936-4 2016 Moreover, if we introduce cystathionine gamma-lyase (CSE), a specific enzyme converting cysteine into H2S, onto the vesicle membrane, the polymersomes can extend their responsive scope from H2S to a specific amino acid bioactivator. Cysteine 88-96 cystathionine gamma-lyase Homo sapiens 53-56 26992682-8 2016 Transfection of CBS and CSE siRNA reversed the stimulatory effect of l-cysteine on VEGF production in placental cells. Cysteine 69-79 cystathionine gamma-lyase Homo sapiens 24-27 24800864-3 2015 H2S is produced from l-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase. Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 70-95 26435880-1 2015 BACKGROUND: Recently a profound depletion of cystathionine gamma-lyase (CSE), the principal enzyme involved in the generation of cysteine from cystathionine, was shown in Huntington disease (HD) patients and several transgenic HD mouse models. Cysteine 129-137 cystathionine gamma-lyase Homo sapiens 45-70 26435880-1 2015 BACKGROUND: Recently a profound depletion of cystathionine gamma-lyase (CSE), the principal enzyme involved in the generation of cysteine from cystathionine, was shown in Huntington disease (HD) patients and several transgenic HD mouse models. Cysteine 129-137 cystathionine gamma-lyase Homo sapiens 72-75 25825818-2 2015 Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 120-130 cystathionine gamma-lyase Homo sapiens 172-197 25825818-2 2015 Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 120-130 cystathionine gamma-lyase Homo sapiens 199-202 27150157-1 2016 Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body. Cysteine 199-209 cystathionine gamma-lyase Homo sapiens 124-149 27150157-1 2016 Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body. Cysteine 199-209 cystathionine gamma-lyase Homo sapiens 151-154 25585997-8 2015 In addition, the cystathionine gamma-lyase (CTH) acivity, a key enzyme in the transsulfuration pathway was enhanced by TMZ, which insured a cysteine supply and GSH synthesis in a compensatory manner when xCT was blocked. Cysteine 140-148 cystathionine gamma-lyase Homo sapiens 17-42 25585997-8 2015 In addition, the cystathionine gamma-lyase (CTH) acivity, a key enzyme in the transsulfuration pathway was enhanced by TMZ, which insured a cysteine supply and GSH synthesis in a compensatory manner when xCT was blocked. Cysteine 140-148 cystathionine gamma-lyase Homo sapiens 44-47 24800864-3 2015 H2S is produced from l-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase. Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 97-100 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Cysteine 43-53 cystathionine gamma-lyase Homo sapiens 94-119 26162829-3 2015 H2S is produced from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 70-95 26162829-3 2015 H2S is produced from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 97-100 24491257-2 2014 H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3MST), and cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 86-111 24491257-2 2014 H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3MST), and cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 113-116 24508802-1 2014 Hydrogen sulfide (H2S), a gasotransmitter, is formed from l-cysteine by multiple enzymes including cystathionine-gamma-lyase (CSE). Cysteine 58-68 cystathionine gamma-lyase Homo sapiens 99-124 24508802-1 2014 Hydrogen sulfide (H2S), a gasotransmitter, is formed from l-cysteine by multiple enzymes including cystathionine-gamma-lyase (CSE). Cysteine 58-68 cystathionine gamma-lyase Homo sapiens 126-129 25539831-3 2014 CBE and CSE are also responsible for the synthesis of cysteine, an essential precursor for glutathione, an antioxidant. Cysteine 54-62 cystathionine gamma-lyase Homo sapiens 8-11 25058799-2 2014 It is synthesized endogenously in mammals from the sulfur-containing amino acid l-cysteine by the action of several distinct enzymes: cystathionine-gamma-lyase (CSE), cystathionine-ss-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) along with cysteine aminotransferase (CAT). Cysteine 80-90 cystathionine gamma-lyase Homo sapiens 134-159 25058799-2 2014 It is synthesized endogenously in mammals from the sulfur-containing amino acid l-cysteine by the action of several distinct enzymes: cystathionine-gamma-lyase (CSE), cystathionine-ss-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) along with cysteine aminotransferase (CAT). Cysteine 80-90 cystathionine gamma-lyase Homo sapiens 161-164 24746521-1 2014 Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Cysteine 91-99 cystathionine gamma-lyase Homo sapiens 182-207 24746521-1 2014 Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Cysteine 91-99 cystathionine gamma-lyase Homo sapiens 209-212 24746521-1 2014 Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Cysteine 101-104 cystathionine gamma-lyase Homo sapiens 182-207 24746521-1 2014 Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Cysteine 101-104 cystathionine gamma-lyase Homo sapiens 209-212 24896355-2 2014 Cystathionine gamma-lyase (CSE) is one major H2S-producing enzyme with L-cysteine as the main substrate in mammalian cells. Cysteine 71-81 cystathionine gamma-lyase Homo sapiens 0-25 24896355-2 2014 Cystathionine gamma-lyase (CSE) is one major H2S-producing enzyme with L-cysteine as the main substrate in mammalian cells. Cysteine 71-81 cystathionine gamma-lyase Homo sapiens 27-30 24491890-1 2014 gamma-Cystathionase (CTH, EC: 4.4.1.1), an enzyme widely distributed in the world of prokaryotic and eukaryotic organisms, catalyzes the formation and transformations of sulfane sulfur-containing compounds and plays a pivotal role in the L-cysteine desulfuration pathway. Cysteine 238-248 cystathionine gamma-lyase Homo sapiens 0-19 24491890-1 2014 gamma-Cystathionase (CTH, EC: 4.4.1.1), an enzyme widely distributed in the world of prokaryotic and eukaryotic organisms, catalyzes the formation and transformations of sulfane sulfur-containing compounds and plays a pivotal role in the L-cysteine desulfuration pathway. Cysteine 238-248 cystathionine gamma-lyase Homo sapiens 21-24 24491890-6 2014 A decrease of the expression of CTH entails a drop in the level of cysteine , glutathione (GSH), taurine and hydrogen sulfide (H2S) in the cells and, more importantly, leads to cystathioninuria. Cysteine 67-75 cystathionine gamma-lyase Homo sapiens 32-35 23872072-7 2013 Cysteine, a CSE preferential substrate for H2S biosynthesis, produced similar effects on the pro-inflammatory cytokine generation, which were reversed by CSE inhibitors PAG and BCA, respectively. Cysteine 0-8 cystathionine gamma-lyase Homo sapiens 12-15 23872072-7 2013 Cysteine, a CSE preferential substrate for H2S biosynthesis, produced similar effects on the pro-inflammatory cytokine generation, which were reversed by CSE inhibitors PAG and BCA, respectively. Cysteine 0-8 cystathionine gamma-lyase Homo sapiens 154-157 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Cysteine 43-53 cystathionine gamma-lyase Homo sapiens 121-124 24036365-3 2013 H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 86-111 24036365-3 2013 H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT). Cysteine 21-31 cystathionine gamma-lyase Homo sapiens 113-116 22841676-12 2012 RESULTS AND LIMITATIONS: CBS and CSE are present in the human bladder dome and efficiently convert L-cysteine into H(2)S. Cysteine 99-109 cystathionine gamma-lyase Homo sapiens 33-36 23515848-1 2013 Cystathionine gamma-lyase (CSE), one of three enzymes in the trans-sulfuration pathway, is responsible for the production of endogenous hydrogen sulfide (H2S) using L-cysteine or L-homocysteine as a substrate. Cysteine 165-175 cystathionine gamma-lyase Homo sapiens 0-25 23515848-1 2013 Cystathionine gamma-lyase (CSE), one of three enzymes in the trans-sulfuration pathway, is responsible for the production of endogenous hydrogen sulfide (H2S) using L-cysteine or L-homocysteine as a substrate. Cysteine 165-175 cystathionine gamma-lyase Homo sapiens 27-30 22841986-2 2012 H(2)S can be synthesized from l-cysteine by cystathionine beta-synthetase (CBS) or cystathionine gamma-lyase (CSE). Cysteine 30-40 cystathionine gamma-lyase Homo sapiens 83-108 22841986-2 2012 H(2)S can be synthesized from l-cysteine by cystathionine beta-synthetase (CBS) or cystathionine gamma-lyase (CSE). Cysteine 30-40 cystathionine gamma-lyase Homo sapiens 110-113 22841676-4 2012 It is predominantly formed from L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). Cysteine 32-42 cystathionine gamma-lyase Homo sapiens 84-109 22841676-4 2012 It is predominantly formed from L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE). Cysteine 32-42 cystathionine gamma-lyase Homo sapiens 111-114 23733596-5 2013 The effect of LC on PIP3 was prevented by propargylglycine, an inhibitor of cystathionine-gamma-lyase (CSE) that catalyzes H2S formation from LC. Cysteine 14-16 cystathionine gamma-lyase Homo sapiens 76-101 23733596-5 2013 The effect of LC on PIP3 was prevented by propargylglycine, an inhibitor of cystathionine-gamma-lyase (CSE) that catalyzes H2S formation from LC. Cysteine 14-16 cystathionine gamma-lyase Homo sapiens 103-106 22907821-2 2013 It is synthesised from cysteine via cystathionine beta-synthase and cystathionine gamma-lyase. Cysteine 23-31 cystathionine gamma-lyase Homo sapiens 68-93 22907821-12 2013 Cysteine and the G1364T and 844ins68 variants of the cystathionine gamma-lyase and cystathionine beta-synthase genes, respectively, are the biological determinants of H(2)S synthesis, and all three are shown here to influence the hypertensive phenotype. Cysteine 0-8 cystathionine gamma-lyase Homo sapiens 53-78 22781905-2 2012 H(2)S is predominantly formed from Cys or its derivatives by the enzymes cystathionine beta-synthase and cystathionine gamma-lyase. Cysteine 35-38 cystathionine gamma-lyase Homo sapiens 105-130 26105277-3 2012 It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 20-30 cystathionine gamma-lyase Homo sapiens 101-126 26105277-3 2012 It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). Cysteine 20-30 cystathionine gamma-lyase Homo sapiens 128-131 22680986-8 2012 The K(M) and V(max) of CSE for cysteine were 3.79 +- 2.07 mM and 0.37 +- 0.02 nmol H(2)S/min, respectively. Cysteine 31-39 cystathionine gamma-lyase Homo sapiens 23-26