PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22905257-1 2012 We previously showed that oxidative stress inhibits leukemia inhibitory factor (LIF) signaling by targeting JAK1, and the catalytic domains of JAK 1 and 2 have a cysteine-based redox switch. Cysteine 162-170 Janus kinase 1 Homo sapiens 143-154 35235776-7 2022 Importantly, JAK1 was directly modified by itaconate derivatives at multiple residues, including cysteines 715, 816, 943, and 1130. Cysteine 97-106 Janus kinase 1 Homo sapiens 13-17 18413761-4 2008 In support of a direct mechanism, CDDO-Me forms adducts with JAK1 at Cys(1077) in the kinase domain and inhibits JAK1 activity. Cysteine 69-72 Janus kinase 1 Homo sapiens 61-65 19706767-6 2009 Addition of DTT or glutathione prevents the JAK cross-linking and blocks the inhibitory effects of HJB on IL-6-induced STAT3 activation, suggesting that HJB may react with cystein residues of JAKs to form covalent bonds that inactivate JAKs. Cysteine 172-179 Janus kinase 1 Homo sapiens 192-196