PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18227104-8 2008 In vitro, gentamicin increased the number of apoptotic cells and caspase-3 activity, but decreased phosphorylation of the prosurvival kinase Akt, in immortalized rat proximal tubular cells; addition of TK and bradykinin prevented these effects. Gentamicins 10-20 kallikrein 1-related peptidase C12 Rattus norvegicus 202-204 18227104-0 2008 Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. Gentamicins 56-66 kallikrein 1-related peptidase C12 Rattus norvegicus 8-25 18227104-3 2008 TK infusion during gentamicin treatment significantly attenuated drug-induced renal dysfunction, cortical damage, and apoptosis. Gentamicins 19-29 kallikrein 1-related peptidase C12 Rattus norvegicus 0-2 18227104-7 2008 Furthermore, TK reduced gentamicin-induced renal dysfunction and fibrosis as evidenced by decreased myofibroblast and collagen accumulation in the kidney. Gentamicins 24-34 kallikrein 1-related peptidase C12 Rattus norvegicus 13-15