PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22896926-0 2012 Gentamicin affects connexin 26 expression in the cochlear lateral wall. Gentamicins 0-10 gap junction protein, beta 2 Rattus norvegicus 19-30 22896926-3 2012 We examined the effects of gentamicin on the expression of connexin 26 to obtain a better understanding of aminoglycoside ototoxicity. Gentamicins 27-37 gap junction protein, beta 2 Rattus norvegicus 59-70 22896926-4 2012 METHODS: We detected changes in connexin 26 protein and mRNA expression in the cochlear lateral wall using immunohistochemistry staining, western blotting, and real-time PCR in rats after administration of a single dose of gentamicin. Gentamicins 223-233 gap junction protein, beta 2 Rattus norvegicus 32-43 22896926-5 2012 RESULTS: The expression of connexin 26 increased over time in type III fibrocytes after gentamicin administration. Gentamicins 88-98 gap junction protein, beta 2 Rattus norvegicus 27-38 22896926-6 2012 Elevated protein levels were detected 3 h after the single injection of gentamicin; while, mRNA levels increased after 24 h. CONCLUSION: Connexin 26 plays an important role in the acute effects of high-dose gentamicin and is probably involved in the pathogenesis of ototoxic deafness. Gentamicins 72-82 gap junction protein, beta 2 Rattus norvegicus 137-148 22896926-6 2012 Elevated protein levels were detected 3 h after the single injection of gentamicin; while, mRNA levels increased after 24 h. CONCLUSION: Connexin 26 plays an important role in the acute effects of high-dose gentamicin and is probably involved in the pathogenesis of ototoxic deafness. Gentamicins 207-217 gap junction protein, beta 2 Rattus norvegicus 137-148