PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12417974-8	2003	Treatment with gentamicin for 6 or 12 h promoted the expression of active caspase-3 and active caspase-9 in many hair cells along the BP as shown by immunohistochemistry.	Gentamicins	15-25	caspase 3	Homo sapiens	74-83	
22965463-4	2012	The goals of this study were to determine if MitoQ attenuates gentamicin-induced activation of caspase-3/7 activity as a marker of apoptosis and to determine if MitoQ impacts aminoglycoside antimicrobial efficacy.	Gentamicins	62-72	caspase 3	Homo sapiens	95-104	
22965463-11	2012	A significant increase in caspase-3/7 activity was observed in cells treated with gentamicin or with idebenone + gentamicin (P = .005).	Gentamicins	82-92	caspase 3	Homo sapiens	26-35	
22965463-11	2012	A significant increase in caspase-3/7 activity was observed in cells treated with gentamicin or with idebenone + gentamicin (P = .005).	Gentamicins	113-123	caspase 3	Homo sapiens	26-35	
21979311-11	2011	Gentamicin increased cleaved PARP and caspase-3, but metformin inhibited the expression of caspase-3 and cleavage of PARP.	Gentamicins	0-10	caspase 3	Homo sapiens	38-47	
15708492-0	2005	Minocycline prevents gentamicin-induced ototoxicity by inhibiting p38 MAP kinase phosphorylation and caspase 3 activation.	Gentamicins	21-31	caspase 3	Homo sapiens	101-110	
15708492-4	2005	Additionally, we demonstrated that gentamicin induced p38 MAPK phosphorylation, cytochrome c release, and caspase 3 activation in these cells and these remarkable changes were blocked by minocycline treatments.	Gentamicins	35-45	caspase 3	Homo sapiens	106-115	
15708492-5	2005	Furthermore, we showed that the inhibitor of p38 MAPK or the inhibitor of caspase 3 only partially blocked gentamicin-induced hair cell damage, and the pretreatment of explants with the inhibitor of p38 MAPK and the inhibitor of caspase 3 together exerted a synergic protective effect against gentamicin-induced hair cell damage.	Gentamicins	107-117	caspase 3	Homo sapiens	74-83	
15708492-5	2005	Furthermore, we showed that the inhibitor of p38 MAPK or the inhibitor of caspase 3 only partially blocked gentamicin-induced hair cell damage, and the pretreatment of explants with the inhibitor of p38 MAPK and the inhibitor of caspase 3 together exerted a synergic protective effect against gentamicin-induced hair cell damage.	Gentamicins	107-117	caspase 3	Homo sapiens	229-238	
15708492-6	2005	Our results suggest that minocycline blocks gentamicin-induced hair cell loss possibly by inhibition of three mechanisms: p38 MAPK phosphorylation, cytochrome c release, and caspase 3 activation.	Gentamicins	44-54	caspase 3	Homo sapiens	174-183	
12417974-9	2003	At these time-points, specific fluorescent-labeled peptide substrates detected more active caspase-3, caspase-8, and caspase-9 in gentamicin-treated hair cells relative to controls.	Gentamicins	130-140	caspase 3	Homo sapiens	91-100	
31997155-5	2020	Gentamicin-induced hair cell death was initiated through the caspase-9 intrinsic apoptotic pathway followed by activation of downstream executioner caspase-3.	Gentamicins	0-10	caspase 3	Homo sapiens	148-157	
31021006-9	2019	Baicalin attenuates gentamicin-induced cochlear hair cells ototoxicity, and such inhibition may be mediated by the regulation of reactive oxygen species production, mitochondrial depolarization, and caspase-3 and PARP activation.	Gentamicins	20-30	caspase 3	Homo sapiens	199-208	
31021006-8	2019	Gentamicin treatment increased the activation of PARP and caspase-3, while such an increase could be downregulated by baicalin.	Gentamicins	0-10	caspase 3	Homo sapiens	58-67