PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17614008-5	2007	The [(3)H]-MPP uptake by hOCT1/rOct1 and hOCT3/rOct3 was inhibited by famotidine and ranitidine whereas that by hOCT2/rOct2 was not.	Famotidine	70-80	solute carrier family 22 member 1	Homo sapiens	25-30	
16141367-0	2005	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).	Famotidine	67-77	solute carrier family 22 member 1	Homo sapiens	91-119	
16141367-0	2005	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).	Famotidine	67-77	solute carrier family 22 member 1	Homo sapiens	121-126	
16141367-0	2005	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).	Famotidine	67-77	solute carrier family 22 member 1	Homo sapiens	128-135	
16141367-3	2005	Inhibition and substrate specificity of hOCT1, hOCT2, and hOCT3 for ranitidine and famotidine were elucidated in cRNA-injected Xenopus laevis oocytes.	Famotidine	83-93	solute carrier family 22 member 1	Homo sapiens	40-45	
16141367-4	2005	Ranitidine and famotidine exhibited similarly potent inhibition of [3H]1-methyl-4-phenyl pyridinium uptake into hOCT1-expressing (IC50= 33 and 28 microM, respectively) and hOCT2-expressing oocytes (IC50= 76 and 114 microM, respectively).	Famotidine	15-25	solute carrier family 22 member 1	Homo sapiens	112-117	
16141367-8	2005	trans-Stimulation and electrophysiology studies suggested that famotidine also is an hOCT1 substrate and exhibits poor or no substrate activity toward hOCT2 and hOCT3.	Famotidine	63-73	solute carrier family 22 member 1	Homo sapiens	85-90	
16141367-9	2005	Thus, hOCT1, which is expressed in the intestine and liver, is likely to play a major role in the intestinal absorption and hepatic disposition of ranitidine and famotidine in humans, whereas hOCT2, the major isoform present in the kidney, may play only a minor role in their renal elimination.	Famotidine	162-172	solute carrier family 22 member 1	Homo sapiens	6-11