PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9068463-11	1997	Fasting serum gastrin levels at weeks 4 and 8 were significantly higher in the lansoprazole group compared with the ranitidine group.	Ranitidine	116-126	gastrin	Homo sapiens	14-21	
22607579-14	2012	Activity of ranitidine lasted about 12 h, whereas that of netazepide exceeded 24 h. CONCLUSIONS: In human: netazepide is an orally active gastrin antagonist, and gastrin has a major role in controlling gastric acidity.	Ranitidine	12-22	gastrin	Homo sapiens	162-169	
12063974-7	2002	RESULTS: Mean gastrin levels in patients receiving ranitidine was 56.76 ng/L and in patients not receiving ranitidine 47.16 ng/L on the first day (pNS) remaining stable throughout the course of acute pancreatitis.	Ranitidine	51-61	gastrin	Homo sapiens	14-21	
12503773-0	2002	Effects of three H2-receptor antagonists (cimetidine, famotidine, ranitidine) on serum gastrin level.	Ranitidine	66-76	gastrin	Homo sapiens	87-94	
12503773-9	2002	The pattern of gastrin change in patients administered ranitidine was intermediate between famotidine and cimetidine.	Ranitidine	55-65	gastrin	Homo sapiens	15-22	
8804870-17	1996	The mean increase in gastrin levels after 12 months" treatment was significantly greater for patients in the lansoprazole group (124.2 pg/ml, P = 0.0056) than those in the ranitidine group (31.9 pg/ml).	Ranitidine	172-182	gastrin	Homo sapiens	21-28	
8180296-14	1994	serum gastrin levels were already elevated during the initial high-dose ranitidine treatment (128 +/- 23 pg/ml).	Ranitidine	72-82	gastrin	Homo sapiens	6-13	
8053433-9	1994	Ranitidine increased fasting serum gastrin levels (22%; p < 0.05 vs. placebo), whereas both lansoprazole regimens produced more marked rises in serum gastrin (54% and 60%; p < 0.05 vs. placebo and ranitidine).	Ranitidine	0-10	gastrin	Homo sapiens	35-42	
8101695-6	1993	Increases in serum gastrin concentrations between the baseline and the 8-wk visit were greater in lansoprazole-treated than in ranitidine-treated patients.	Ranitidine	127-137	gastrin	Homo sapiens	19-26	
8281874-4	1994	The mean integrated 24-hr plasma gastrin concentration during dosing with ranitidine 150 mg four times a day was 904 pmol/hr/liter compared with placebo (410 pmol/hr/liter)--an increase of 122%.	Ranitidine	74-84	gastrin	Homo sapiens	33-40	
7875420-0	1994	[Variations of plasma gastrin (basal and postprandial) in ththtreatmentof duodenal ulcer with either enprostil or ranitidine.	Ranitidine	114-124	gastrin	Homo sapiens	22-29	
7875420-3	1994	This is at variance with the elevation of plasma gastrin observed with ranitidine.	Ranitidine	71-81	gastrin	Homo sapiens	49-56	
8285777-5	1993	Serum gastrin concentration was > 150 ng/l in four patients on omeprazole and in three patients on ranitidine.	Ranitidine	102-112	gastrin	Homo sapiens	6-13	
8490080-8	1993	Basal serum gastrin concentrations, which were already elevated by the previous high-dose ranitidine treatment (125 +/- 25 pg/ml), rose to four times the normal values after 4 weeks of treatment with lansoprazole (255 +/- 65 pg/ml).	Ranitidine	90-100	gastrin	Homo sapiens	12-19	
8472980-5	1993	The expected rise in meal stimulated plasma gastrin with ranitidine was seen in the 12 patients who received ranitidine but, despite suppression of H pylori urease activity in 10 of 12 patients taking ranitidine bismuth citrate, there was no attenuation of the meal stimulated gastrin rise.	Ranitidine	57-67	gastrin	Homo sapiens	44-51	
8472980-5	1993	The expected rise in meal stimulated plasma gastrin with ranitidine was seen in the 12 patients who received ranitidine but, despite suppression of H pylori urease activity in 10 of 12 patients taking ranitidine bismuth citrate, there was no attenuation of the meal stimulated gastrin rise.	Ranitidine	109-119	gastrin	Homo sapiens	44-51	
1427586-0	1992	Gastric acid secretion and plasma gastrin during short-term treatment with omeprazole and ranitidine in duodenal ulcer patients.	Ranitidine	90-100	gastrin	Homo sapiens	34-41	
1427586-7	1992	The increase in fasting plasma gastrin observed after ranitidine and omeprazole was 86% and 242%, respectively, on day 7, and 13% and 103% twenty-four hours after final dose.	Ranitidine	54-64	gastrin	Homo sapiens	31-38	
2103756-0	1990	Gastric histology and plasma gastrin response to a meal in patients with duodenal ulcer disease after five years treatment with ranitidine.	Ranitidine	128-138	gastrin	Homo sapiens	29-36	
1889719-8	1991	Either intermittent or continuous dosing with ranitidine was associated with an elevation of plasma gastrin concentration, which remained constant throughout the 5-month study.	Ranitidine	46-56	gastrin	Homo sapiens	100-107	
1685675-9	1991	Fasting and meal-stimulated plasma gastrin concentrations were increased on the final treatment day with ranitidine and famotidine but had returned to pretreatment levels two days after treatment.	Ranitidine	105-115	gastrin	Homo sapiens	35-42	
1862300-0	1991	24-hour intragastric acidity and plasma gastrin during long-term treatment with omeprazole or ranitidine in patients with reflux esophagitis.	Ranitidine	94-104	gastrin	Homo sapiens	40-47	
1675024-9	1991	Since acid blockade by proton pump inhibitors or H2-receptor blockers dose-dependently increase serum gastrin levels, patients with ranitidine-resistant peptic ulceration receiving long-term treatment with high-dose omeprazole have been followed up with serial gastric biopsy specimens for up to 5 years.	Ranitidine	132-142	gastrin	Homo sapiens	102-109	
2390929-5	1990	Plaunotol in combination with ranitidine significantly increased secretin release and inhibited gastrin release after a meal.	Ranitidine	30-40	gastrin	Homo sapiens	96-103	
2390929-6	1990	Intravenous infusion of secretin resulted in significant suppression of postprandial gastrin release exaggerated by ranitidine.	Ranitidine	116-126	gastrin	Homo sapiens	85-92	
1736336-0	1992	Effect of duodenal ulcer healing induced by omeprazole and ranitidine on the generation of gastroduodenal eicosanoids, platelet-activating factor, pepsinogen A, and gastrin in duodenal ulcer patients.	Ranitidine	59-69	gastrin	Homo sapiens	165-172	
2277968-2	1990	Furthermore, we have demonstrated in eight patients with reflux oesophagitis that 2-week treatment courses with 300 mg ranitidine twice daily and 300 mg four times daily progressively decreased 24-h intraoesophageal acidity but only moderately elevated basal and meal-stimulated serum gastrin concentrations, significantly below gastrin values obtained after a 2-week treatment course with 20mg omeprazole once daily.	Ranitidine	119-129	gastrin	Homo sapiens	285-292	
1983349-4	1990	During oral dosing with ranitidine 300 mg, compared with intravenous saline, the pentagastrin infusion returned acidity towards normal (67 to 293 pmol.h/L; P less than 0.001) and lowered gastrin (209 to 135 pmol.h/L; P less than 0.001).	Ranitidine	24-34	gastrin	Homo sapiens	86-93	
2093018-6	1990	Basal serum gastrin levels, which were already elevated by the previous high-dose ranitidine treatment, rose to 4 times normal levels after 4 months of treatment with omeprazole.	Ranitidine	82-92	gastrin	Homo sapiens	12-19	
2277968-2	1990	Furthermore, we have demonstrated in eight patients with reflux oesophagitis that 2-week treatment courses with 300 mg ranitidine twice daily and 300 mg four times daily progressively decreased 24-h intraoesophageal acidity but only moderately elevated basal and meal-stimulated serum gastrin concentrations, significantly below gastrin values obtained after a 2-week treatment course with 20mg omeprazole once daily.	Ranitidine	119-129	gastrin	Homo sapiens	329-336	
3410170-9	1988	Serum gastrin levels were already elevated during the initial high-dose ranitidine treatment (106 +/- 15.4 pg/ml).	Ranitidine	72-82	gastrin	Homo sapiens	6-13	
2513641-6	1989	Serum gastrin levels were already elevated approximately 2-fold during the initial high-dose ranitidine treatment and rose a further 2-fold at 2-3 months of omeprazole treatment.	Ranitidine	93-103	gastrin	Homo sapiens	6-13	
2904394-4	1988	Dosing with ranitidine 300 mg at 21:00 h also caused a simultaneous significant decrease of morning acidity (-32%; p less than 0.05) with a significant increase of plasma gastrin concentration (+36%; p less than 0.05), but the antisecretory effects of nizatidine 150 or 300 mg at 21:00 h were only observed during the night, with no effect during the morning.	Ranitidine	12-22	gastrin	Homo sapiens	171-178	
3127265-9	1988	Gastrin levels reflected changes in intragastric pH over the 24 h time frame and were noted to increase during ranitidine and enteral nutrition.	Ranitidine	111-121	gastrin	Homo sapiens	0-7	
3818148-5	1986	Mean integrated gastrin responses after pirenzepine and ranitidine alone as well as pirenzepine plus ranitidine were not significantly different from placebo.	Ranitidine	56-66	gastrin	Homo sapiens	16-23	
2979226-3	1987	Median integrated 24-hour intragastric acidity was decreased significantly from 1148 to 490 and 36 mmol.hour litre-1 during treatment with ranitidine and omeprazole, respectively, whilst median intragastric 24-hour plasma gastrin was raised significantly from 328 to 799 and 1519 pmol.hour litre-1 respectively.	Ranitidine	139-149	gastrin	Homo sapiens	222-229	
2986474-7	1985	However, in the subjects who had received ranitidine on the night prior to surgery, the fasting serum gastrin was significantly higher (p less than 0.01) than the values in the remaining subjects, the mean (SEM) values being 60.3 (6.3) pg/ml in those not receiving ranitidine and 111.3 (19.5) pg/ml in those who had been given ranitidine.	Ranitidine	42-52	gastrin	Homo sapiens	102-109	
2410935-0	1985	Effects of eight-week treatment with oral ranitidine on plasma level changes of gastrin, histamine and serotonin in duodenal ulcer patients.	Ranitidine	42-52	gastrin	Homo sapiens	80-87	
2410935-2	1985	Elevated plasma gastrin and histamine levels, as well as intragastric pH were found after four weeks of ranitidine treatment, only in patients whose ulcers had healed.	Ranitidine	104-114	gastrin	Homo sapiens	16-23	
2410935-4	1985	It is suggested that the increases in plasma gastrin, histamine and serotonin levels could be due to gastric and duodenal acid reductions by ranitidine.	Ranitidine	141-151	gastrin	Homo sapiens	45-52	
2878726-9	1986	The serum concentrations of total gastrin, G-17, and G-34 were reduced with enprostil and with ranitidine.	Ranitidine	95-105	gastrin	Homo sapiens	34-41	
3702129-0	1986	[Chronological effect of histamine H2 receptor antagonist ranitidine as serum gastrin response in gastric ulcer patients].	Ranitidine	58-68	gastrin	Homo sapiens	78-85	
2986474-7	1985	However, in the subjects who had received ranitidine on the night prior to surgery, the fasting serum gastrin was significantly higher (p less than 0.01) than the values in the remaining subjects, the mean (SEM) values being 60.3 (6.3) pg/ml in those not receiving ranitidine and 111.3 (19.5) pg/ml in those who had been given ranitidine.	Ranitidine	265-275	gastrin	Homo sapiens	102-109	
2986474-7	1985	However, in the subjects who had received ranitidine on the night prior to surgery, the fasting serum gastrin was significantly higher (p less than 0.01) than the values in the remaining subjects, the mean (SEM) values being 60.3 (6.3) pg/ml in those not receiving ranitidine and 111.3 (19.5) pg/ml in those who had been given ranitidine.	Ranitidine	265-275	gastrin	Homo sapiens	102-109	
2856908-7	1985	Plasma gastrin levels were increased by cimetidine and ranitidine, both in the interdigestive and in the postprandial state.	Ranitidine	55-65	gastrin	Homo sapiens	7-14	
6125203-9	1982	Upon oral administration, ranitidine exerted no effect on gastric emptying of the meal but slightly decreased the gastrin response to the meal.	Ranitidine	26-36	gastrin	Homo sapiens	114-121	
6293900-5	1982	Finally, 6 healthy fasting subjects were given a 1-hour intravenous infusion of gastrin after pretreatment with ranitidine.	Ranitidine	112-122	gastrin	Homo sapiens	80-87