PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3034296-5 1987 Indomethacin (5 micrograms/ml) completely inhibited PGE stimulation by rIL-1 beta, but only partially inhibited that of GAG overproduction and had no effect on collagenase production. Prostaglandins E 52-55 interleukin 1 beta Rattus norvegicus 71-81 2553025-3 1989 When stimulated by appropriate concentrations of recombinant interleukin-1 beta (rIL-1 beta), ASC proliferate and produce PGE. Prostaglandins E 122-125 interleukin 1 beta Rattus norvegicus 81-91 19552966-3 2009 Somatostatin further enhanced the increase in PGE(2) release induced by IL-1beta, whereas cortistatin inhibited such increase. Prostaglandins E 46-49 interleukin 1 beta Rattus norvegicus 72-80 31690022-3 2019 The spikenard extract significantly inhibited IL-1beta-stimulated production of IL-6, IL-8, metalloproteinase (MMP)-1, MMP-13, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and prostaglandin(PG)E2 in a dose-dependent manner but not MMP-3 production. Prostaglandins E 194-213 interleukin 1 beta Rattus norvegicus 46-54 22236721-8 2012 This may relate to arsenic-mediated local release of tumor necrosis factor-alpha and interleukin-1beta, which causes cyclooxygenase induction and consequent prostaglandin-E(2) release. Prostaglandins E 157-172 interleukin 1 beta Rattus norvegicus 85-102 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 63-66 interleukin 1 beta Rattus norvegicus 45-53 19141058-9 2009 Stimulation with IL-1beta increased the level of PGE(2) in conditioned media of cultured FLS in a time-dependent manner up to 48 h. Immunohistochemistry showed a strong positive staining for COX-2 in the lining and sub-lining synovial tissues of the TMJ of IL-1beta-injected rats. Prostaglandins E 49-52 interleukin 1 beta Rattus norvegicus 17-25 19141058-11 2009 CONCLUSION: These data suggest that COX-2 expression stimulated by IL-1beta stimulates the production of PGE(2) in FLS and plays important roles in the progression of inflammation in TMJ. Prostaglandins E 105-108 interleukin 1 beta Rattus norvegicus 67-75 19235895-10 2009 LPS promotes IL-1beta secretion from enteric glial cells, resulting in augmentation of the neural response to BK through PGE(2) release via glial PLA(2) and COX-2. Prostaglandins E 121-124 interleukin 1 beta Rattus norvegicus 13-21 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 63-66 interleukin 1 beta Rattus norvegicus 75-83 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 92-95 interleukin 1 beta Rattus norvegicus 45-53 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 92-95 interleukin 1 beta Rattus norvegicus 75-83 18053651-9 2008 IL-1beta treatment increased BK-induced PGE(2) release from cultured myenteric plexus cells. Prostaglandins E 40-43 interleukin 1 beta Rattus norvegicus 0-8 18053651-10 2008 These results suggest that IL-1beta promotes up-regulation of B1R expression in glial cells, resulting in the potentiation of neural responses to BK through the elevation of PGE(2) released from glial cells. Prostaglandins E 174-177 interleukin 1 beta Rattus norvegicus 27-35 17600562-16 2007 Administration of lipopolysaccharide or interleukin-1beta to ovariectomized female rats induces cerebrovascular COX-2 and inducible nitric oxide synthase (iNOS) protein expression and increases prostaglandin E(2) expression. Prostaglandins E 194-209 interleukin 1 beta Rattus norvegicus 40-57 16883638-10 2006 IL-1beta increased the production of PGE(2) in a dose- and time-dependent manner. Prostaglandins E 37-40 interleukin 1 beta Rattus norvegicus 0-8 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins E 141-144 interleukin 1 beta Rattus norvegicus 62-70 16883638-4 2006 In the present study, we examined the influence of interleukin-1beta (IL-1beta) on prostaglandin E(2) (PGE(2)) release, and the effect of 3-phenyl-2-propene-1-ol on IL-1beta-induced PGE(2) release from rat cerebral endothelial cells (rCMEC). Prostaglandins E 83-98 interleukin 1 beta Rattus norvegicus 70-78 17234889-8 2007 Furthermore, IL-1beta upregulated inducible nitric oxide (NO) synthase and cyclooxygenase-2 mRNA and protein and thus stimulated NO and PGE(2) productions. Prostaglandins E 136-139 interleukin 1 beta Rattus norvegicus 13-21 16939916-10 2006 CONCLUSION: PGE(1) can protect against ischemia-reperfusion injury of the rat liver partially by suppressing KCs activation, reducing excessive release of TNF-alpha and IL-1beta from KCs and decreasing the high expression of MCP-1 protein and mRNA. Prostaglandins E 12-15 interleukin 1 beta Rattus norvegicus 169-177 16603549-2 2006 Treatment of the rat gastric epithelial cell line RGM1 with transforming growth factor-alpha and interleukin-1beta leads to synergistic release of arachidonate and production of prostaglandin E(2). Prostaglandins E 178-193 interleukin 1 beta Rattus norvegicus 97-114 16427196-7 2006 IL-1beta on spinal PGE(2) production in the absence and presence of peripheral formalin inflammation with spinal microdialysis in freely moving rats. Prostaglandins E 19-22 interleukin 1 beta Rattus norvegicus 0-8 16427196-13 2006 The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). Prostaglandins E 69-72 interleukin 1 beta Rattus norvegicus 51-59 16427196-14 2006 Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation. Prostaglandins E 97-100 interleukin 1 beta Rattus norvegicus 61-69 15471850-4 2004 In this study, we have shown that treatment of rat islets with IL-1beta or human islets with a cytokine mixture containing IL-1beta + IFN-gamma +/- TNF-alpha stimulates COX-2 expression and PGE(2) formation in a time-dependent manner. Prostaglandins E 190-193 interleukin 1 beta Rattus norvegicus 63-71 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Prostaglandins E 0-3 interleukin 1 beta Rattus norvegicus 55-63 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 134-149 interleukin 1 beta Rattus norvegicus 15-32 11274144-9 2001 These results suggest that synergistic stimulation of sPLA(2) and COX-2 expression by TGF-alpha and IL-1beta results in an increase in PGE(2). Prostaglandins E 135-138 interleukin 1 beta Rattus norvegicus 100-108 11352824-5 2001 Inhibition of activated NF-kappaB action resulted in suppression of both their mRNA expression and increases in PGE(2) and CINC-1 levels induced by interleukin-1beta. Prostaglandins E 112-115 interleukin 1 beta Rattus norvegicus 148-165 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 134-149 interleukin 1 beta Rattus norvegicus 34-42 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 154-157 interleukin 1 beta Rattus norvegicus 15-32 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 154-157 interleukin 1 beta Rattus norvegicus 34-42 11251208-5 2001 Interleukin-1beta (1 U) injection into the same PGE(2) responsive thermogenic sites in the mPOA elicited a prolonged rise in colonic temperature (T(c)) (+1.02+/-0.06 degrees C) that persisted for at least 2 h. Glycyl-glutamine (3 nmol) co-injection into the mPOA inhibited IL-1beta thermogenesis completely (T(c)=-0.18+/-0.22 degrees C). Prostaglandins E 48-51 interleukin 1 beta Rattus norvegicus 0-17 11287034-1 2001 OBJECTIVE: Determine if aspirin inhibits the IL-1 beta-stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in rat ovarian dispersates cultured in vitro. Prostaglandins E 163-166 interleukin 1 beta Rattus norvegicus 45-54 11287034-9 2001 RESULT(S): Administration of IL-1 beta increased nitrite and PGE(2) levels over that observed in the control group after culture of ovarian dispersates for 24 and 48 hours. Prostaglandins E 61-64 interleukin 1 beta Rattus norvegicus 29-38 11287034-13 2001 CONCLUSION(S): Aspirin significantly inhibits the IL-1 beta-stimulated expression of iNOS, NO, and PGE(2) in ovarian dispersates cultured in vitro. Prostaglandins E 99-102 interleukin 1 beta Rattus norvegicus 50-59 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Prostaglandins E 98-101 interleukin 1 beta Rattus norvegicus 0-17 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Prostaglandins E 98-101 interleukin 1 beta Rattus norvegicus 19-27 11530235-1 2001 Interleukin 1beta induced both nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities, and corresponding increases in the production of nitric oxide and prostaglandin E(2). Prostaglandins E 257-272 interleukin 1 beta Rattus norvegicus 0-17 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Prostaglandins E 199-202 interleukin 1 beta Rattus norvegicus 139-156 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Prostaglandins E 199-202 interleukin 1 beta Rattus norvegicus 158-166 8418905-5 1993 TNF alpha and IL-1 beta stimulated production of prostaglandin E and prostaglandin F2 alpha in a dose-dependent manner during a 24-h incubation. Prostaglandins E 49-64 interleukin 1 beta Rattus norvegicus 14-23 9359471-0 1997 Interleukin-1 beta inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric oxide and prostaglandin E accumulation. Prostaglandins E 154-169 interleukin 1 beta Rattus norvegicus 0-18 21153236-7 1995 Both IL-1beta and TNFalpha increased P and PGE secretion time- and dose-dependently. Prostaglandins E 43-46 interleukin 1 beta Rattus norvegicus 5-13 21153236-8 1995 In summary, IL-1beta dose-dependently inhibits the LH-induced increase in PA activity in rat preovulatory folliclesin vitro while, as with TNFalpha, increasing P and PGE synthesis. Prostaglandins E 166-169 interleukin 1 beta Rattus norvegicus 12-20