PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12494456-9	2003	Examining the effect of a major product of COX 1 in an in vitro system of human colonic epithelial monolayers, prostaglandin E(2) (PGE(2)) in low concentration (10(-6) M) enhanced epithelial barrier function and partially protected epithelia from the barrier-disruptive consequences of a pro-inflammatory cytokine, IFN-gamma.	Prostaglandins E	111-126	prostaglandin-endoperoxide synthase 1	Homo sapiens	43-48	
12056853-10	2002	Reducing PGE(2) synthesis by Indomethacin [a cyclo-oxygenase (COX) -1 and -2 inhibitor] reduced IL-6 levels in all osteoarthritic Ob, whereas Naproxen (a more selective COX-2 inhbitor) reduced PGE(2) and IL-6 levels only in the high osteoarthritic group.	Prostaglandins E	9-12	prostaglandin-endoperoxide synthase 1	Homo sapiens	45-76	
12538084-1	2003	Cyclooxygenase-1 is the primary isoform responsible for the production of cytoprotective prostaglandins (PGE(2) and PGI(2)) in the stomach.	Prostaglandins E	105-108	prostaglandin-endoperoxide synthase 1	Homo sapiens	0-16	
11809691-11	2002	We found that the cAMP-linked PGE(2) receptors were significantly up-regulated by COX-1 overexpression coincident with enhanced cAMP responsiveness of these cells to exogenous PGE(2) ligand.	Prostaglandins E	30-33	prostaglandin-endoperoxide synthase 1	Homo sapiens	82-87	
11809691-7	2002	Overexpression of COX-1 in HeLa cells resulted in induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E synthase (PGES) concomitant with increased prostaglandin E(2) (PGE(2)) synthesis.	Prostaglandins E	127-130	prostaglandin-endoperoxide synthase 1	Homo sapiens	18-23	
11809691-8	2002	Treatment of HeLa cells overexpressing COX-1 with the dual COX enzyme inhibitor indomethacin or selective COX-2 inhibitor NS-398 significantly reduced PGE(2) synthesis.	Prostaglandins E	151-154	prostaglandin-endoperoxide synthase 1	Homo sapiens	39-44	
10585861-12	1999	In the presence of exogenous arachidonic acid the COS-7 cells expressing human PGHS-1 produced substantial amounts of PGE(2) and 8-epi-PGF(2alpha).	Prostaglandins E	118-121	prostaglandin-endoperoxide synthase 1	Homo sapiens	79-85	
22696602-5	2012	Treatment of CD cells with either cyclooxygenase-1 (COX-1) or COX-2 inhibitors during exposure to FSS limited the increase in PGE(2) concentration to an equal extent, suggesting COX-1 and COX-2 contribute equally to FSS-induced PGE(2) release.	Prostaglandins E	126-129	prostaglandin-endoperoxide synthase 1	Homo sapiens	34-50	
22696602-5	2012	Treatment of CD cells with either cyclooxygenase-1 (COX-1) or COX-2 inhibitors during exposure to FSS limited the increase in PGE(2) concentration to an equal extent, suggesting COX-1 and COX-2 contribute equally to FSS-induced PGE(2) release.	Prostaglandins E	126-129	prostaglandin-endoperoxide synthase 1	Homo sapiens	52-57	
19542367-9	2009	Although specific blockade of EP2 receptors is considered a promising therapeutic strategy in RA, opposite regulation of proinflammatory IL-6 and prodestructive MMP-1 by PGE(2) via EP2 may require more complex approaches to successfully inhibit the cyclooxygenase-1/2 cAMP axis.	Prostaglandins E	170-173	prostaglandin-endoperoxide synthase 1	Homo sapiens	249-265	
21502318-6	2011	SII-stimulated PGES3 phosphorylation coincided with an increase in beta-arrestin 1-associated PGES3 and an arrestin-dependent increase in cyclooxygenase 1-dependent prostaglandin E(2) synthesis.	Prostaglandins E	165-180	prostaglandin-endoperoxide synthase 1	Homo sapiens	138-154