PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12069489-5	2002	We were only able to obtain a good fit to available experimental data on the relation between pheomelanin levels and the activity of the key enzyme tyrosinase by taking Ito"s hypothesis into account.	pheomelanin	94-105	tyrosinase	Homo sapiens	148-158	
19449448-3	2009	Enzymatic components of melanosomes include tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase, which depend on the functions of OA1, P, MATP, ATP7A, and BLOC-1 to synthesize eumelanins and pheomelanins.	pheomelanin	208-220	tyrosinase	Homo sapiens	44-54	
8867704-1	1994	Biochemical specifity of malignant melanoma is represented in part by the formation of specific cytoplasmatic particles of the pigment cell--melanosomes--in which the synthesis of pigment eumelanin and pheomelanin takes place and in part by the presence of a specific enzyme--tyrosinase--which catalyzes the formation of pigment eumelanin and pheomelanin and even the formation of specific metabolites (so called melanogens) which are excreted in increased amounts in the course of the disease.	pheomelanin	202-213	tyrosinase	Homo sapiens	276-286	
11041367-11	2000	Because of the absence of TRP-1 and TRP-2 in pheomelanogenesis, it may be suggested that tyrosinase is involved in lysosomal degradation after forming dopaquinone, to which the cysteine present in the lysosomal granule binds to form cysteinyldopas that will then be auto-oxidized to become pheomelanin.	pheomelanin	290-301	tyrosinase	Homo sapiens	89-99	
9107139-0	1996	Mouse fibroblast expressing human tyrosinase with DHICA-oxidase activity produces predominantly pheomelanin deposit in lysosome.	pheomelanin	96-107	tyrosinase	Homo sapiens	34-44	
9367182-5	1997	We prepared pheomelanins by tyrosinase oxidation of dopa or tyrosine in the presence of cysteine.	pheomelanin	12-24	tyrosinase	Homo sapiens	28-38	
8433004-7	1993	When tyrosinase activity is low, dopaquinone, a reactive intermediate in melanogenesis, is quantitatively converted to glutathionyldopa, which gives rise exclusively to pheomelanin.	pheomelanin	169-180	tyrosinase	Homo sapiens	5-15	
8348959-2	1993	Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types.	pheomelanin	77-88	tyrosinase	Homo sapiens	0-10	
1900307-6	1991	Quantitative hairbulb tyrosinase (dopa oxidase) assay demonstrated a loss of activity above 35-37 degrees C. Plasma pheomelanin and urine eumelanin intermediates were reduced and correlated with hair melanin content.	pheomelanin	116-127	tyrosinase	Homo sapiens	22-32	
28271633-3	2017	The oxidation of tyrosine by tyrosinase in the presence of cysteine forms cysteinyldopa isomers, which are further oxidized to give rise to pheomelanin via benzothiazine intermediates.	pheomelanin	140-151	tyrosinase	Homo sapiens	29-39	
28271633-6	2017	We found that pheomelanin production either from dopa or tyrosine in the presence of cysteine by tyrosinase was greatest at pH values of 5.8-6.3, while eumelanin production was suppressed at pH 5.8.	pheomelanin	14-25	tyrosinase	Homo sapiens	97-107	
33871027-3	2021	Melanogenesis consists of a series of biochemical and enzymatic reactions catalysed by tyrosinase and other tyrosinase-related proteins, leading to the formation of two types of melanin, eumelanin and pheomelanin.	pheomelanin	201-212	tyrosinase	Homo sapiens	87-97	
33871027-3	2021	Melanogenesis consists of a series of biochemical and enzymatic reactions catalysed by tyrosinase and other tyrosinase-related proteins, leading to the formation of two types of melanin, eumelanin and pheomelanin.	pheomelanin	201-212	tyrosinase	Homo sapiens	108-118	
25026474-3	2014	Tyrosinase is the critical enzyme in the biosynthesis of both brown/black eumelanin and yellow/red pheomelanin.	pheomelanin	99-110	tyrosinase	Homo sapiens	0-10