PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34855907-6 2021 Participants were categorised as either "carriers" or "non-carriers" of the risk allele for 4 SNPs: two related to D binding protein (DBP) and associated with lower 25(OH)D levels (rs4588 and rs7041), and two related to vitamin D metabolism enzymes CYP27B1 and CYP24A1 and associated with a higher risk of MS (rs12368653; rs2248359, respectively). 25(oh)d 165-172 D-box binding PAR bZIP transcription factor Homo sapiens 134-137 34855907-8 2021 RESULTS: The DBP-related SNPs showed no difference in 25(OH)D status at baseline, but carriers of the rs7041 risk allele showed lower 25(OH)D-levels compared to non-carriers after 48 weeks of supplementation (median 224.2 vs. 332.0 nmol/L, p = 0.013). 25(oh)d 134-141 D-box binding PAR bZIP transcription factor Homo sapiens 13-16 33114526-5 2020 This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. 25(oh)d 92-99 D-box binding PAR bZIP transcription factor Homo sapiens 19-22 34080787-4 2021 METHODS: Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), for 25(OH)D, DBP, and the molar ratio of 25(OH)D:DBP, an estimate of unbound (free) 25(OH)D levels. 25(oh)d 150-157 D-box binding PAR bZIP transcription factor Homo sapiens 158-161 35102371-1 2022 BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret. 25(oh)d 146-153 D-box binding PAR bZIP transcription factor Homo sapiens 202-205 35102371-1 2022 BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret. 25(oh)d 263-270 D-box binding PAR bZIP transcription factor Homo sapiens 202-205 35122787-5 2022 In patients" sera, positive correlations were detected between t-25(OH)D-vitamin D binding protein (DBP) values by both routine methods, and between t-25(OH)D-albumin values by all three methods. 25(oh)d 65-72 D-box binding PAR bZIP transcription factor Homo sapiens 100-103 35163226-2 2022 Furthermore, high DBP levels might negatively affect free 25(OH)D concentrations. 25(oh)d 58-65 D-box binding PAR bZIP transcription factor Homo sapiens 18-21 33205195-9 2021 Associations were stronger and significant restricting to 14 hrHPV types (25(OH)D per 10ng/mL increase: aOR=1.82,95%CI:1.15-2.88 and aOR=4.19,95%CI:1.18-14.88 DBP-adjusted; 25(OH)D>=30 vs <30ng/mL: aOR=8.85,95%CI:2.69-29.06; 24,25(OH)2D: aOR=1.85,95%CI:1.18-2.88). 25(oh)d 74-81 D-box binding PAR bZIP transcription factor Homo sapiens 159-162 34579103-1 2021 (1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. 25(oh)d 197-204 D-box binding PAR bZIP transcription factor Homo sapiens 87-90 34078483-5 2022 Plasma 25(OH)D was analyzed by LC-MS/MS and free 25(OH)D was calculated utilizing the levels and binding affinities of DBP and albumin for 25(OH)D. 25(oh)d 49-56 D-box binding PAR bZIP transcription factor Homo sapiens 119-122 34078483-5 2022 Plasma 25(OH)D was analyzed by LC-MS/MS and free 25(OH)D was calculated utilizing the levels and binding affinities of DBP and albumin for 25(OH)D. 25(oh)d 139-146 D-box binding PAR bZIP transcription factor Homo sapiens 119-122 35511609-9 2022 In adjusted analyses, a 10 nmol/L increase of s-25(OH)D in early pregnancy associated with a 0.3/0.2 mmHg lower SBP/DBP at 5 years (p <0.05). 25(oh)d 48-55 D-box binding PAR bZIP transcription factor Homo sapiens 116-119 35511609-10 2022 Optimal s-25(OH)D (>75 nmol/L) in early pregnancy was associated with lower 5-year SBP and DBP, beta (95%CI) -1.45 (-2.6,-0.3), and -0.97 (-1.9,-0.1), compared with reference s-25(OH)D 50-74.9 nmol/L. 25(oh)d 10-17 D-box binding PAR bZIP transcription factor Homo sapiens 91-94 35511609-11 2022 Two-stage analysis combining early pregnancy, late pregnancy, and cord s-25(OH)D data showed an inverse association with 5-year SBP and DBP for boys (p <0.025) with significant sex-difference for DBP (pinteraction=0.004). 25(oh)d 73-80 D-box binding PAR bZIP transcription factor Homo sapiens 136-139 35511609-11 2022 Two-stage analysis combining early pregnancy, late pregnancy, and cord s-25(OH)D data showed an inverse association with 5-year SBP and DBP for boys (p <0.025) with significant sex-difference for DBP (pinteraction=0.004). 25(oh)d 73-80 D-box binding PAR bZIP transcription factor Homo sapiens 196-199 35509637-10 2022 Baseline total and free 25(OH)D concentrations were positively associated with 1,25(OH)2D, 24,25(OH)2D (p < 0.001), vitamin D binding protein (DBP) (p < 0.05), BMD, and BMC (p < 0.05). 25(oh)d 24-31 D-box binding PAR bZIP transcription factor Homo sapiens 143-146 35509637-12 2022 After supplementation, total and free 25(OH)D concentrations remained positively associated only with 24,25(OH)2D (p < 0.001) and DBP (p < 0.001) and negatively with estimated glomerular filtration rate (eGFR) (p < 0.01). 25(oh)d 38-45 D-box binding PAR bZIP transcription factor Homo sapiens 130-133 33114526-6 2020 When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. 25(oh)d 66-73 D-box binding PAR bZIP transcription factor Homo sapiens 19-22 31358089-1 2019 OBJECTIVE: To identify DBP gene rs4588 and rs7041 polymorphisms and associate with participants" serum 25(OH)D and BMD levels. 25(oh)d 103-110 D-box binding PAR bZIP transcription factor Homo sapiens 23-26 32357490-8 2020 DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. 25(oh)d 41-48 D-box binding PAR bZIP transcription factor Homo sapiens 0-3 32357490-8 2020 DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. 25(oh)d 97-104 D-box binding PAR bZIP transcription factor Homo sapiens 0-3 30668751-10 2019 Higher 25(OH)D was not associated with incident CKD overall, but it was associated with lower odds of incident CKD among participants with the GG or GT genotype at rs7041 in the gene encoding DBP [OR, 0.69 per 5 ng/mL higher 25(OH)D; 95% CI, 0.51 to 0.93; P-interaction = 0.005]. 25(oh)d 7-14 D-box binding PAR bZIP transcription factor Homo sapiens 192-195 30668751-10 2019 Higher 25(OH)D was not associated with incident CKD overall, but it was associated with lower odds of incident CKD among participants with the GG or GT genotype at rs7041 in the gene encoding DBP [OR, 0.69 per 5 ng/mL higher 25(OH)D; 95% CI, 0.51 to 0.93; P-interaction = 0.005]. 25(oh)d 225-232 D-box binding PAR bZIP transcription factor Homo sapiens 192-195 30668751-12 2019 CONCLUSION: These findings support a potential benefit of higher 25(OH)D for kidney health in black Americans with diabetes or specific variants in DBP. 25(oh)d 65-72 D-box binding PAR bZIP transcription factor Homo sapiens 148-151 28095044-4 2017 The majority of circulating 25(OH)D and 1,25-dihydroxyvitamin D is tightly bound to DBP and albumin, with less than 1% circulating in an unbound form. 25(oh)d 28-35 D-box binding PAR bZIP transcription factor Homo sapiens 84-87 30959383-10 2019 CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults. 25(oh)d 90-97 D-box binding PAR bZIP transcription factor Homo sapiens 47-50 27919752-1 2017 Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. 25(oh)d 115-122 D-box binding PAR bZIP transcription factor Homo sapiens 182-185 27919752-1 2017 Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. 25(oh)d 115-122 D-box binding PAR bZIP transcription factor Homo sapiens 198-201 21924736-3 2012 Serum 25(OH)D was correlated with urinary vitamin D binding protein/creatinine ratio (DBP/C) and other indicators of proteinuria. 25(oh)d 6-13 D-box binding PAR bZIP transcription factor Homo sapiens 86-89 25618772-3 2016 Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical membrane. 25(oh)d 9-16 D-box binding PAR bZIP transcription factor Homo sapiens 53-56 25904602-1 2015 BACKGROUND: Vitamin D-binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. 25(oh)d 91-98 D-box binding PAR bZIP transcription factor Homo sapiens 39-42 21924736-4 2012 RESULTS: Serum 25(OH)D levels in subjects with SLE were inversely associated with the natural log of urinary DBP/C (r=-0.63, P<.001) and urine protein to creatinine ratio (r=-0.60, P<.001), with an adjusted mean 10.9-ng/mL (95% CI, 5.1-16.8) decrease in 25(OH)D for those with proteinuria. 25(oh)d 15-22 D-box binding PAR bZIP transcription factor Homo sapiens 109-112