PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33940646-10	2021	A positive correlation was found between hepcidin and ferritin (R2 = 0.247, p = 0.02) and a negative correlation was found between 25(OH)D and CRP (R2 = 0.1, p = 0.04).	25(oh)d	131-138	C-reactive protein	Homo sapiens	143-146	
33940646-15	2021	Negative correlation was found between 25(OH)D and CRP..	25(oh)d	39-46	C-reactive protein	Homo sapiens	51-54	
34591347-7	2021	In addition, the mean serum 25(OH)D concentration was significantly lower in the patient group than that in control group (p < 0.05), and serum CRP was significantly increased (p < 0.05).	25(oh)d	28-35	C-reactive protein	Homo sapiens	144-147	
33807159-6	2021	An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03).	25(oh)d	44-51	C-reactive protein	Homo sapiens	65-68	
33807159-6	2021	An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03).	25(oh)d	44-51	C-reactive protein	Homo sapiens	211-214	
34089603-5	2021	Elevated serum 25(OH)D concentrations were significantly associated with lower levels of insulin, HOMA-IR, triglyceride, and C-reactive protein, and higher levels of high-density lipoprotein at baseline (all Ptrend<0.05).	25(oh)d	15-22	C-reactive protein	Homo sapiens	125-143	
34579742-10	2021	Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157).	25(oh)d	6-13	C-reactive protein	Homo sapiens	247-250	
35579027-5	2022	RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4).	25(oh)d	64-71	C-reactive protein	Homo sapiens	111-114	
34590566-13	2021	After adjusting for age, gender, atrial fibrillation, nutritional risk, hs-CRP and other confounding factors, serum 25(OH)D was an independent protective factor for the infarct volume of AIS in anterior circulation (odds ratio (OR) = 0.962, P = 0.040), For every 10 mug/L decrease of 25(OH)D, the risk of one grade increase in infarction volume was increased by 47.7% respectively (goodness of fit: chi2 = 5.357, P = 0.719).	25(oh)d	116-123	C-reactive protein	Homo sapiens	75-78	
34590566-13	2021	After adjusting for age, gender, atrial fibrillation, nutritional risk, hs-CRP and other confounding factors, serum 25(OH)D was an independent protective factor for the infarct volume of AIS in anterior circulation (odds ratio (OR) = 0.962, P = 0.040), For every 10 mug/L decrease of 25(OH)D, the risk of one grade increase in infarction volume was increased by 47.7% respectively (goodness of fit: chi2 = 5.357, P = 0.719).	25(oh)d	284-291	C-reactive protein	Homo sapiens	75-78	
35579027-5	2022	RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4).	25(oh)d	64-71	C-reactive protein	Homo sapiens	122-125	
35579027-5	2022	RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4).	25(oh)d	167-174	C-reactive protein	Homo sapiens	111-114	
35579027-5	2022	RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4).	25(oh)d	167-174	C-reactive protein	Homo sapiens	122-125	
35579027-5	2022	RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4).	25(oh)d	281-288	C-reactive protein	Homo sapiens	111-114	
35579027-6	2022	Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations.	25(oh)d	147-154	C-reactive protein	Homo sapiens	159-162	
35579027-8	2022	CONCLUSION: The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency.	25(oh)d	45-52	C-reactive protein	Homo sapiens	57-60	
33468272-9	2021	Body mass index (BMI) was found to have significant mediation effects (to varied extent) on the associations between serum 25(OH)D and CRP, apo-B, fasting glucose, insulin, HOMA-IR, HOMA-B and HbA1c (all p<0.05).	25(oh)d	123-130	C-reactive protein	Homo sapiens	135-138	
35571939-3	2022	Cox regression was used to analyze the relationship between Serum 25(OH)D, cadmium, CRP, and all-cause, cause-specific mortality.	25(oh)d	66-73	C-reactive protein	Homo sapiens	84-87	
35571939-4	2022	We used restricted cubic splines to explore the dose-response relationship between serum 25(OH)D, cadmium, CRP, and all-cause mortality.	25(oh)d	89-96	C-reactive protein	Homo sapiens	107-110	
35571939-9	2022	Restricted cubic splines analysis showed a significant nonlinear association between serum 25(OH)D (P-nonlinearity P < 0.001), cadmium (P-nonlinearity = 0.002), CRP (P-nonlinearity = 0.003), and HR for all-cause mortality risk in diabetic patients.	25(oh)d	91-98	C-reactive protein	Homo sapiens	161-164	
35450844-8	2022	25(OH)D level was positively correlated with eGFR, calcium, albumin, hemoglobin, transferrin saturation, serum iron, while a negative correlation was found with heart rate, parathormon, NT-proBNP, and CRP.	25(oh)d	0-7	C-reactive protein	Homo sapiens	201-204	
33662886-11	2021	In stratified analyses, the significant negative association between cord blood 25(OH)D with foetal hs-CRP and glucolipid metabolic indexes was observed only at low-medium levels of air pollution exposure.	25(oh)d	80-87	C-reactive protein	Homo sapiens	103-106	
33121835-10	2021	25(OH)D significantly directly related with white blood cells count and the different components of leukocytes formula, Neutrophils-to-Lymphocytes Ratio, Monocytes-to-Lymphocytes Ratio and C-reactive protein, but not with lymphocytes levels.	25(oh)d	0-7	C-reactive protein	Homo sapiens	189-207	
33687883-9	2021	Serum 25(OH)D was positively correlated with BMD (lumbar and femoral; p=0.002 and p=0.01 respectively) and Z scores (lumbar and femoral; p<0.001and p=0.01 respectively), whereas, negatively correlated with ASDAS-CRP (p<0.001), BASFI (p<0.001), mSASSS (p=0.003).	25(oh)d	6-13	C-reactive protein	Homo sapiens	212-215	
33168652-7	2021	Higher serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA of insulin resistance, HbA1c, blood lipids, and C-reactive protein at baseline (all P trend < 0.05).	25(oh)d	13-20	C-reactive protein	Homo sapiens	150-168	
32311700-12	2021	IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy.	25(oh)d	208-215	C-reactive protein	Homo sapiens	333-336	
32311700-12	2021	IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy.	25(oh)d	208-215	C-reactive protein	Homo sapiens	333-336	
33468272-10	2021	Both waist circumference and apVAT were also found to partly mediate the associations between serum 25(OH)D with CRP, FBG, HbA1c, triglycerides and HDL-cholesterol (all P < 0.05).	25(oh)d	100-107	C-reactive protein	Homo sapiens	113-116	
32232398-11	2020	25(OH)D was inversely associated with sICAM-1, hs-CRP, and AGP, which were positively associated with BMI.	25(oh)d	0-7	C-reactive protein	Homo sapiens	50-53	
33340057-9	2022	A negative correlation was observed between 25(OH)D and 25(OH)D3 serum levels and Birmingham vasculitis activity score (BVAS), C-reactive protein (CRP), and white blood cell count.	25(oh)d	44-51	C-reactive protein	Homo sapiens	127-145	
33340057-9	2022	A negative correlation was observed between 25(OH)D and 25(OH)D3 serum levels and Birmingham vasculitis activity score (BVAS), C-reactive protein (CRP), and white blood cell count.	25(oh)d	44-51	C-reactive protein	Homo sapiens	147-150	
33340057-10	2022	Linear regression analysis indicated haemoglobin and 25(OH)D levels to be independently associated with BVAS and CRP and 25(OH)D levels with SF-36 MCS score.	25(oh)d	53-60	C-reactive protein	Homo sapiens	113-116	
32684941-7	2020	Increased serum 25(OH)D was significantly associated with decreasing TC, TG, HDL-C, LDL-C, and hs-CRP levels.	25(oh)d	16-23	C-reactive protein	Homo sapiens	98-101	
32684941-9	2020	Mediators that had appreciable shares of the associations between 25(OH)D and hs-CRP was TG (10.2% of the association; beta = - 0.011; total indirect effect: 95% CI: - 0.019, - 0.002).	25(oh)d	66-73	C-reactive protein	Homo sapiens	81-84	
32684941-10	2020	The cubic model suggested that a steep increase in the adjusted regression coefficient of lipid with hs-CRP up to 50 nmol/L of 25(OH)D, and the highest adjusted regression coefficients were observed in pregnant women with 25(OH)D above 50 nmol/L.	25(oh)d	127-134	C-reactive protein	Homo sapiens	104-107	
32684941-10	2020	The cubic model suggested that a steep increase in the adjusted regression coefficient of lipid with hs-CRP up to 50 nmol/L of 25(OH)D, and the highest adjusted regression coefficients were observed in pregnant women with 25(OH)D above 50 nmol/L.	25(oh)d	222-229	C-reactive protein	Homo sapiens	104-107	
32325367-2	2020	Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship.	25(oh)d	78-85	C-reactive protein	Homo sapiens	92-110	
32325367-2	2020	Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship.	25(oh)d	78-85	C-reactive protein	Homo sapiens	112-115	
32325367-8	2020	Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference).	25(oh)d	100-107	C-reactive protein	Homo sapiens	161-164	
32325367-8	2020	Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference).	25(oh)d	100-107	C-reactive protein	Homo sapiens	390-393	
32325367-9	2020	CONCLUSION: We found that measures of adiposity largely explained the negative association of serum 25(OH)D with the pro-inflammatory CRP and leptin, and the positive association with the anti-inflammatory adiponectin.	25(oh)d	100-107	C-reactive protein	Homo sapiens	134-137	
32871878-4	2020	Serum 25(OH)D levels were negatively correlated with hs-CRP, while not with TNF-alpha.	25(oh)d	6-13	C-reactive protein	Homo sapiens	56-59	
30885444-2	2019	The secondary objective was to investigate a correlation between 25(OH)D and CRP.	25(oh)d	65-72	C-reactive protein	Homo sapiens	77-80	
32296394-9	2020	Serum 25(OH)D concentration was significantly negatively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-sensitivity C-reactive protein (hs-CRP) (P < 0.05).	25(oh)d	6-13	C-reactive protein	Homo sapiens	286-304	
30885444-8	2019	25(OH)D varied with age, ethnic origin, BMI, season, CRP and medical history.	25(oh)d	0-7	C-reactive protein	Homo sapiens	53-56	
30885444-11	2019	25(OH)D was inversely correlated with CRP.	25(oh)d	0-7	C-reactive protein	Homo sapiens	38-41	
30885444-13	2019	25(OH)D was inversely correlated with CRP as observed in the general population.	25(oh)d	0-7	C-reactive protein	Homo sapiens	38-41	
30682545-9	2019	CONCLUSION: We found a strong association between 25(OH)D concentrations and the prognostic indicator CCI and clinical complications (acute respiratory insufficiency, acute liver failure, and infections), but no associations with the prognostic indicators APACHE II and SOFA score, CRP, mechanical ventilation duration, or mortality.	25(oh)d	50-57	C-reactive protein	Homo sapiens	282-285	
31385179-9	2019	Serum 25(OH)D levels showed significant but weak inverse correlations with CRP (r = - 0.205, p = 0.020) and with NLR (r = - 0.219, p = 0.013).	25(oh)d	6-13	C-reactive protein	Homo sapiens	75-78	
27819306-7	2016	Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis.	25(oh)d	19-26	C-reactive protein	Homo sapiens	110-128	
24797104-11	2015	Therefore, the measurement of serum 25(OH)D levels and appropriate vitamin D supplementation should be considered in anemic patients, particularly in females and patients with high CRP level.	25(oh)d	36-43	C-reactive protein	Homo sapiens	181-184	
30355032-8	2018	In multivariate analyses, low serum bioavailable 25(OH)D level was significantly associated with increased risks of mortality, independent of established cardiovascular risk factors, features and treatments of CAD, factors associated with vitamin D and mineral metabolism, and CRP (C-reactive protein).	25(oh)d	49-56	C-reactive protein	Homo sapiens	277-280	
30355032-8	2018	In multivariate analyses, low serum bioavailable 25(OH)D level was significantly associated with increased risks of mortality, independent of established cardiovascular risk factors, features and treatments of CAD, factors associated with vitamin D and mineral metabolism, and CRP (C-reactive protein).	25(oh)d	49-56	C-reactive protein	Homo sapiens	282-300	
29320465-6	2018	CRP concentrations were higher in individuals with lower 25(OH)D concentrations.	25(oh)d	57-64	C-reactive protein	Homo sapiens	0-3	
24167365-2	2013	This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP).	25(oh)d	72-79	C-reactive protein	Homo sapiens	216-234	
24167365-2	2013	This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP).	25(oh)d	72-79	C-reactive protein	Homo sapiens	236-239